Activation of leptin expression by an inhibitor of carnitine palmitoyltransferase-1

Wolkowicz, Paul E.; Grenett, Hernan E.; Belousova, Maria; Urthaler, Ferdinand

doi:10.1038/sj.ijo.0802585

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Leptin resistance and elevated plasma leptin concentrations have been reported in renal failure, not only due to increased fat mass, but also due to reduced renal leptin cleavage 35. Leptin concentrations can be related to CPT‐I gene expression 36–38. Leptin regulates fatty acid homeostasis through its receptor, the product of the db gene, which activates the Jak/STAT pathway.…”

Section: Is the Carnitine System A Link Between Malnutrition And Inflmentioning

confidence: 99%

Carnitine Replacement in End‐Stage Renal Disease and Hemodialysis

Calvani

Benatti

Mancinelli

et al. 2004

Annals of the New York Academy of Sciences

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In patients with chronic renal failure, not yet undergoing hemodialysis (HD), plasma acylcarnitines accumulate in part due to a decreased renal clearance of esterified carnitine moieties. In these patients, a high acylcarnitine/free-carnitine ratio is usually found in plasma. Patients undergoing maintenance HD, usually present with plasma carnitine insufficiency, due to accumulation of metabolic intermediates combined with impaired carnitine biosynthesis, reduced protein intake and increased removal via HD. Plasma carnitine concentrations rapidly decrease to 40% of baseline level during the dialysis session, with a slow restoration of the carnitine concentration during the interdialytic period, mainly from organs of storage (skeletal muscle). Dietary intake also plays an important role in carnitine homeostasis of HD patients since the prevalence of malnutrition ranges from 18% to 75% of these cases. This could differentially affect various body compartments, with clinical consequences such as impaired muscle function, decreased wound healing, altered ventilatory response, and abnormal immune function. Repeated hemodialytic treatments are associated with decreased carnitine stores in skeletal muscle. The administration of intravenous L-carnitine (LC) postdialysis replenishes the free carnitine removed from the blood and contributes to replenishment of muscle carnitine content. LC supplementation in selected uremic patients may yield clinical benefits by ameliorating several conditions, such as erythropoietin-resistant anemia, decreased cardiac performance, intradialytic hypotension, muscle symptoms, as well as impaired exercise and functional capacities. Furthermore, LC may positively influence the nutritional status of HD patients by promoting a positive protein balance, and by reducing insulin resistance and chronic inflammation, possibly through an effect on leptin resistance.

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Section: Is the Carnitine System A Link Between Malnutrition And Inflmentioning

confidence: 99%

Carnitine Replacement in End‐Stage Renal Disease and Hemodialysis

Calvani

Benatti

Mancinelli

et al. 2004

Annals of the New York Academy of Sciences

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“…Moreover, carnitine supplementation is relevant for the fatigue treatment of cancer chemotherapy, 13 multiple sclerosis, 14 fibromyalgia 15 haemodialysis, 16 coeliac disease 17 and also in patients with CHC who received interferon therapy 18 . Interestingly, experimental findings support that carnitine palmitotransferase‐1 linked fatty acid oxidation is a key modulator of leptin expression 19 . In healthy ponies, carnitine supplementation has been associated with enhanced glucose tolerance and increase in leptin concentration 20 …”

Section: Introductionmentioning

confidence: 99%

“…18 Interestingly, experimental findings support that carnitine palmitotransferase-1 linked fatty acid oxidation is a key modulator of leptin expression. 19 In healthy ponies, carnitine supplementation has been associated with enhanced glucose tolerance and increase in leptin concentration. 20 In this study, we aimed at determining the contributory role of plasma levels of carnitine on fatigue in patients with untreated CHC and IBS.…”

Section: Introductionmentioning

confidence: 99%

Plasma carnitine is associated with fatigue in chronic hepatitis C but not in the irritable bowel syndrome

Anty¹,

Marjoux²,

Bekri³

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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“…Wolkowicz 44 , et al reported that CPT-1 linked Accumulating evidence from animal and human studies indicate that pharmacologic doses of L-carnitine have immunomodulatory effects resembling those of glucocorticoids as it is a 'nutritional modulator' of glucoreceptors 60 . The significant decrease in plasma corticosterone (p<0.05) (Table 1) in the present study is thus, an effect of L-carnitine supplementation.…”

Section: Appetite Regulatory Hormonesmentioning

confidence: 99%

Effect of L-carnitine and Hoodia gordonii Supplementation on Metabolic Markers and Physical Performance under Short Term Calorie Restriction in Rats

Jain¹,

Singh²

2016

DSJ

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Calorie restriction can occur as a consequence of food shortage due to natural calamities, war like situations or voluntarily for health benefits. This state of negative energy balance leads to decrease in performance and increase in feeling of hunger. A normal individual can sustain himself on stored energy in form of body fat for a period of time. It was hypothesised that use of an appetite suppressant like Hoodia gordonii along with L-carnintine, which helps in fat oxidation can be used as strategy for coping adverse situation without compromising physical performance. The aim of the study was to evaluate the combined effect of H. gordonii and L-carnitine supplementation on metabolic changes and appetite regulatory peptides during calorie restriction. Male albino rats were divided into two groups (n=12 in each) i.e. control (without treatment) and treated (H. gordonii organic solvent extract and L-carnitine, orally for 5 days at a dose of 100 mg/kg under 25 per cent calorie restriction). Biochemical variables including regulatory peptides were estimated along with physical efficiency tests. Significant changes in ghrelin, leptin, corticosterone and thyroid hormones were observed in comparison to control. While blood glucose, AMP kinase decreased significantly in the treated group, an increase in CPT-1 activity was observed compared with controls. It is concluded that approach could be practically suitable and effective in emergency situations of combat or food shortage.

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Activation of leptin expression by an inhibitor of carnitine palmitoyltransferase-1

Cited by 4 publications

References 17 publications

Carnitine Replacement in End‐Stage Renal Disease and Hemodialysis

Carnitine Replacement in End‐Stage Renal Disease and Hemodialysis

Plasma carnitine is associated with fatigue in chronic hepatitis C but not in the irritable bowel syndrome

Effect of L-carnitine and Hoodia gordonii Supplementation on Metabolic Markers and Physical Performance under Short Term Calorie Restriction in Rats

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