Activation of metabolism of the GABA system in the cerebral hemispheres by stress factors

Adaptation to Short-Term Stress Exposures Prevents Poststress Dysfunction of Calcium-Activated Potassium Channels in Coronary Vessels

“…Therefore, functional activity of BK Ca channels occurs only during smooth muscle cell (4). c: L-NAME (1); L-NAME+stress (2); L-NAME+adaptation (3); LNAME+adaptation+stress (4).…”

“…The level of myogenic tone and, therefore, the diameter of vessels can vary signifi cantly at the same blood pressure under different physiological conditions. This situation occurs due to changes in the expression or functional acti vity of large-conductance calcium-activated potassium channels (BK Ca channels) in smooth muscle cells that play a key role in the regulation of pressure-related myogenic tone [9].Adaptation of animals by short-term stress exposures has a strong effect on the production of nitric oxide (NO), main stage in the pathogenesis of poststress hypotonia of coronary vessels [2,3], abolishes the decrease in myocardial contractility under stress conditions [1,4], attenuates the stress-induced activation of LPO [5], and prevents dysfunction of Ca 2+ pumps [4] and K ATP channels [1]. Functional activity of BK Ca channels increases under the infl uence of cyclic nucleotides (cGMP and cAMP) and depends on the oxidized/ reduced glutathione ratio (redox state of cells).…”

“…Adaptation of animals by short-term stress exposures has a strong effect on the production of nitric oxide (NO), main stage in the pathogenesis of poststress hypotonia of coronary vessels [2,3], abolishes the decrease in myocardial contractility under stress conditions [1,4], attenuates the stress-induced activation of LPO [5], and prevents dysfunction of Ca 2+ pumps [4] and K ATP channels [1]. Functional activity of BK Ca channels increases under the infl uence of cyclic nucleotides (cGMP and cAMP) and depends on the oxidized/ reduced glutathione ratio (redox state of cells).…”