Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL‐10 induced modulation of phagocyte antifungal activity

Haraguchi, Norihiro; Kikuchi, Norihiro; Morishima, Yuko; Matsuyama, Masashi; Sakurai, Hirofumi; Shibuya, Akira; Shibuya, Kazuko; Taniguchi, Masaru; Ishii, Yukio

doi:10.1002/eji.201545987

Cited by 10 publications

(10 citation statements)

References 43 publications

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“…Enhanced secretion of IL-10 has been reported to increase susceptibility of mice to infections by mycobacterial and fungal pathogens (63–67). Moreover, blocking IL-10 production enhanced the protective efficacy of BCG vaccination against M. tuberculosis infection (68).…”

Section: Mincle Modulates Inflammatory Responsesmentioning

confidence: 99%

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

2017

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The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle’s immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle’s biology with an emphasis on its diverse functions in immunity.

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Section: Mincle Modulates Inflammatory Responsesmentioning

confidence: 99%

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

2017

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“…3a, the concentrations of serum IL-6, IL-10, and TNF-α in ABX group were significantly higher than those in the CNV group, whereas the levels of IL-17A, IFN-γ, IL-12, and IL-22 were significantly decreased. A previous study has shown that administration of IL-10 increased host susceptibility to candidiasis [54], while IL-17, IFN-γ, IL-12, and IL-22 played an important role in protecting against candida [55].…”

Section: Inflammatory Response Was Aggravated In Abx Mice During Invamentioning

confidence: 94%

Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis

et al. 2020

Crit Care

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Background: The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. Methods: In this work, an antibiotic cocktail was used to eliminate the intestinal microbiota of conventionalhoused (CNV) C57/BL6 mice, and then both antibiotic-treated (ABX) mice and CNV mice were intravenously infected with Candida albicans to investigate their differential responses to infection. Furthermore, fecal microbiota transplantation (FMT) was applied to ABX mice in order to assess its effects on host immunity against invasive candidiasis after restoring the intestinal microbiota, and 16S ribosomal RNA gene sequencing was conducted on fecal samples from both uninfected ABX and CNV group of mice to analyze their microbiomes. Results: We found that ABX mice displayed significantly increased weight loss, mortality, and organ damage during invasive candidiasis when compared with CNV mice, which could be alleviated by FMT. In addition, the level of IL-17A in ABX mice was significantly lower than that in the CNV group during invasive candidiasis. Treatment with recombinant IL-17A could improve the survival of ABX mice during invasive candidiasis. Besides, the microbial diversity of ABX mice was significantly reduced, and the intestinal microbiota structure of ABX mice was significantly deviated from the CNV mice. Conclusions: Our data revealed that intestinal microbiota plays a protective role in invasive candidiasis by enhancing IL-17A production in our model system.

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“…i NKT cells contribute to the pathogenesis of C. albicans infection, the most frequent Candida species. Following systemic C. albicans infection, Jα18-deficient mice lacking i NKT cells exhibited a higher survival rate and a lower fungal burden in various organs than wild-type (WT) mice because of the increased accumulation of macrophages and neutrophils in the peritoneal cavity ( 52 ). Consistent with the amelioration of infection by i NKT cell depletion, IL-10 levels were lower and IL-12p40 levels were higher in the serum of C. albicans -infected Jα18-deficient mice than infected WT mice.…”

Section: Nkt Cells Contribute To the Pathogenesis Of Some mentioning

confidence: 99%

“…Consistent with the amelioration of infection by i NKT cell depletion, IL-10 levels were lower and IL-12p40 levels were higher in the serum of C. albicans -infected Jα18-deficient mice than infected WT mice. Conversely, NKT cell transfer exacerbated C. albicans infection in Jα18-deficient mice concomitant with reduced accumulation of macrophages and neutrophils ( 52 ). Furthermore, IL-10 treatment exacerbated C. albicans infection in Jα18-deficient mice, and transfer of IL-10-deficient NKT cells into Jα18-deficient mice significantly increased survival following C. albicans infection compared to the transfer of WT NKT cells ( 52 ).…”

Section: Nkt Cells Contribute To the Pathogenesis Of Some mentioning

confidence: 99%

“…Conversely, NKT cell transfer exacerbated C. albicans infection in Jα18-deficient mice concomitant with reduced accumulation of macrophages and neutrophils ( 52 ). Furthermore, IL-10 treatment exacerbated C. albicans infection in Jα18-deficient mice, and transfer of IL-10-deficient NKT cells into Jα18-deficient mice significantly increased survival following C. albicans infection compared to the transfer of WT NKT cells ( 52 ). However, another study found no difference in susceptibility to C. albicans infection between Jα18-deficient and WT mice ( 53 ).…”

Section: Nkt Cells Contribute To the Pathogenesis Of Some mentioning

confidence: 99%

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Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control

et al. 2018

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CD1d-restricted invariant natural killer T (iNKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans. These iNKT cells recognize endogenous, microbial, and synthetic glycolipid antigens presented by the major histocompatibility complex (MHC) class I-like molecule CD1d. Upon TCR stimulation by glycolipid antigens, iNKT cells rapidly produce large amounts of cytokines, including interferon-γ (IFNγ) and interleukin-4 (IL-4). Activated iNKT cells contribute to host protection against a broad spectrum of microbial pathogens, and glycolipid-mediated stimulation of iNKT cells ameliorates many microbial infections by augmenting innate and acquired immunity. In some cases, however, antigen-activated iNKT cells exacerbate microbial infections by promoting pathogenic inflammation. Therefore, it is important to identify appropriate microbial targets for the application of iNKT cell activation as a treatment or vaccine adjuvant. Many studies have found that iNKT cell activation induces potent adjuvant activities promoting protective vaccine effects. In this review, we summarize the functions of CD1d-restricted iNKT cells in immune responses against microbial pathogens and describe the potential applications of glycolipid-mediated iNKT cell activation for preventing and controlling microbial infections.

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Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL‐10 induced modulation of phagocyte antifungal activity

Cited by 10 publications

References 43 publications

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis

Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control

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