Activation of nitroaldol reactions by diethylzinc and amino alcohols or diamines as promoters

Catalytic asymmetric Henry reaction

“…20 Following Trost's work of dinuclear zinc catalyst, Reiser et al disclosed in detail that the Henry reaction can be promoted by Et 2 Zn in the assistance of either diamine or amino alcohols. 21 Working in this area Lin and co-workers synthesised a new class of b-amino alcohol ligands with a bicyclo[3,3,0]octane scaffold for enantioselective Henry reactions. 22 Under optimal conditions, the complex formed in situ between 5 mol % of 38 (Fig.…”

A New CopperII/Isopropylidene‐2,2‐bis(oxazoline) Catalyst and Its Stable Reactive Complex with Acryloyloxazolidinone in Enantioselective Reactions

“…The catalyst is strongly exo-selective and (3'R,4'R)-8 b is obtained in a good 85 % ee. [23] To test the importance of the triflate anion in the reacting intermediates, the above reactions have been performed by using a catalyst obtained from 4, 6 and MS (Tables 1, 2, entries 4 and 3, respectively), the reaction time is somewhat longer, but the results are very similar to those obtained with 5.…”

“…But 10, contrary to 5, has a water molecule as the axial ligand. Therefore two further n Catalyst [b] [8b]/ 6 , without MS, one with 5 equivalents water added to 5 ( Table 1, entries 7 and 8). In general, water does not have a beneficial effect on organometallic catalysts since its Lewis-basic site tends to preclude binding to the organic reactants, modifying the supramolecular architecture of the complex involved in the catalysis.…”

Synthesis and cytotoxicity of 1-phenylethanolamine carboxamide derivatives: effects on the cell cycle

“…The reaction of substituted benzaldehydes with nitroethane under the Henry aldol condensation conditions yielded the nitrophenylethanol derivatives 2a and 2b (Desai et al, 2004;Kleina et al, 2002). The nitro groups of these compounds were reduced by catalytic hydrogenation in the presence of 5% Pd/C and the resulting amino compounds were reacted with various carboxylic acids under different conditions to give the 1-phenylethanolamine arylcarboxamides 3a-3g in reasonable yields (Scheme 1).…”