Activation of splenic dendritic cells by bacterial and allogeneic antigens

Stanislawska, J; Interewicz, B; Maksymowicz, M; Wl, Olszewski

doi:10.1016/j.transproceed.2004.12.158

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…Since then, PSE has become a major therapy clinically for hypersplenism. The spleen represents one fourth of the total lymphatic mass, serves as a biological filter for the clearance of bacteria and also is essential for rapid antibody production after challenge with blood-borne particulate antigens in the absence of preexisting antibodies [11] . In addition, the spleen appears to be the site of production of a nonspecific leukophilic immunoglobin, tuftsin, that increases the phagocytic activity of polymorphonuclear leucocytes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia

Lee

Leung

Wang

et al. 2007

WJG

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AIM:To investigate the effect of partial splenic embolization (PSE) on platelet values in liver cirrhosis patients with thrombocytopenia and to determine the effective embolization area for platelet values improvement. METHODS:Blood parameters and liver function indicators were measured on 10 liver cirrhosis patients (6 in Child-Pugh grade A and 4 in grade B) with thrombocytopenia (platelet values < 80 × 10 3 /μL) before embolization. Computed tomography scan was also needed in advance to acquire the splenic baseline. After 2 to 3 d, angiography and splenic embolization were performed. A second computed tomography scan was made to confirm the embolization area after 2 to 3 wk of embolization. The blood parameters of patients were also examined biweekly during the 1 year follow-up period. RESULTS:According to the computed tomography images after partial splenic embolization, we divided all patients into two groups: low (< 30%), and high (≥ 30%) embolization area groups. The platelet values were increased by 3 times compared to baseline levels after 2 wk of embolization in high embolization area group. In addition, there were significant differences in platelet values between low and high embolization area groups. GPT values decreased significantly in all patients after 2 wk of embolization. The improvement in platelet and GPT values still persisted until 1 year after PSE. In addition, 3 of 4 (75%) Child-Pugh grade B patients progressed to grade A after 2 mo of PSE. The complication rate in < 30% and ≥ 30% embolization area groups was 50% and 100%, respectively.

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Section: Discussionmentioning

confidence: 99%