Activation of T lymphocytes by polysaccharide–protein complex from Lycium barbarum L.

Chen, Zhisong; Tan, Benny Kwong Huat; Chan, Soh Ha

doi:10.1016/j.intimp.2008.07.019

Cited by 124 publications

(96 citation statements)

References 40 publications

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“…On the contrary, LBP-3, LBP-4, and LBP-5 enhanced the cell viability. This was consistent with the previous studies that LBP could promote the proliferation of murine lymphocytes [20].…”

Section: Characterization Of Lbp Fractionssupporting

confidence: 94%

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Deng

Li²,

Luo

et al. 2017

Food & Nutrition Research

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The antitumor activity of Lycium barbarum polysaccharide (LBP) has been reported, but the structure-bioactivity relationship has still not been fully elucidated. In this study, four watersoluble LBP fractions with serial different molecular weights (MWs) were separated from LBP, designated LBP-2, LBP-3, LBP-4, and LBP-5. After a characteristic analysis, the relationship between MW and antitumor activity of LBP was investigated both in vitro using murine hepatoma H22 cells and in vivo using H22 tumor-bearing mice. In vitro, the results showed that all the LBP fractions had significant inhibition on H22 cells, in which LBP-3 had the best activity. LBP-3 could induce apoptosis, mitochondrial membrane potential destruction, and S phase arrest in H22 cells. In vivo, the results showed that LBP-2, LBP-3, LBP-4, and LBP-5 could inhibit the tumor growth in H22 tumor-bearing mice by 18.18%, 37.97%, 9.09%, and 14.44%, respectively. However, only LBP-3 was able to decrease the tumor weight significantly in H22 tumor-bearing mice. Meanwhile, all the LBP fractions did not show significant toxicity to murine splenocytes, thymus, and spleen. Taken together, these results demonstrated that the antitumor activity of LBP was closely related to its MW, and LBP-3 with medium MW (40-350 kDa) was the main active fraction. ARTICLE HISTORY

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“…On the contrary, LBP-3, LBP-4, and LBP-5 enhanced the cell viability. This was consistent with the previous studies that LBP could promote the proliferation of murine lymphocytes [20].…”

Section: Characterization Of Lbp Fractionssupporting

confidence: 94%

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Deng

Li²,

Luo

et al. 2017

Food & Nutrition Research

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show abstract

“…Due to differences between cell populations, Cordyceps sphecocephala J201 cultures did not show any toxicity in the cells, whereas the increase of proliferation exhibits the potential activity of cell growth promotion. In particular, the active ingredient in DongChungHaCho's polysaccharide is known to activate the immune cells (33).…”

Section: Resultsmentioning

confidence: 99%

Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201

Heo

Nam²,

Nam³

et al. 2010

Int J Mol Med

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Abstract. This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.

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“…It has also been demonstrated that LBP can promote cytokine secretion in macrophages, Th1, and Th2 [16]. Researchers have consistently shown that LBP significantly induces proliferation of T lymphocytes [4,17]. However, not much was hitherto know about the anti-apoptotic and antioxidant effects of LBP in lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…In Chinese traditional medicine, the use of Lycium barbarum as a functional food for promoting immunity and longevity were documented as far back as 2,800 BC [2]. Studies have shown that Lycium barbarum polysaccharide (LBP), a major active component of Lycium barbarum, attenuates cytotoxicity, lowers blood glucose, enhances immunity, and also possesses anti-cancer properties [3][4][5]. Apoptosis is closely associated with lymphocyte development and homeostasis [6].…”

Section: Introductionmentioning

confidence: 99%

Impact of <i>Lycium barbarum</i> polysaccharide on apoptosis in <i>Mycoplasma</i>-infected splenic lymphocytes

Huang¹,

Zheng²,

Xu³

2017

Trop. J. Pharm Res

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Activation of T lymphocytes by polysaccharide–protein complex from Lycium barbarum L.

Cited by 124 publications

References 40 publications

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201

Impact of <i>Lycium barbarum</i> polysaccharide on apoptosis in <i>Mycoplasma</i>-infected splenic lymphocytes

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