1995
DOI: 10.1016/0378-1097(95)00041-3
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Activation of the actinorhodin biosynthetic pathway in Streptomyces lividans

Abstract: Production of the antibiotic actinorhodin was activated in Streptomyces lividarts under conditions in which it is not normally produced when transformed with an activator gene from S. lividans. The gene encodes a Sdnucleotide transcript, responsible for the actinorhodin production phenotype, which is homologous to the 132 nucleotide transcript from S. fradiae, thought to act as a putative antisense RNA.

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Cited by 10 publications
(15 citation statements)
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“…Also, a probable acyl-CoA dehydrogenase (SCO6938) belonging to this island has been implicated in control of actinorhodin production and timing of sporulation [38]. This observation is particularly interesting considering the extremely low-levels of actinorhodin production [39] and absence (or silencing) of the ram -independent developmental pathway in S. lividans [40]. Furthermore, two putative DNA methylases (SCO6844 and SCO6885) also map to this locus.…”
Section: Resultsmentioning
confidence: 99%
“…Also, a probable acyl-CoA dehydrogenase (SCO6938) belonging to this island has been implicated in control of actinorhodin production and timing of sporulation [38]. This observation is particularly interesting considering the extremely low-levels of actinorhodin production [39] and absence (or silencing) of the ram -independent developmental pathway in S. lividans [40]. Furthermore, two putative DNA methylases (SCO6844 and SCO6885) also map to this locus.…”
Section: Resultsmentioning
confidence: 99%
“…To date, several genes have been reported to activate the production of actinorhodin in S. coelicolor A3(2) or its close relative S. lividans. Thus, introduction by a multicopy plasmid of the gene afsR (25) or abaA (14) or an activator gene from S. lividans (47) activates actinorhodin production in S. lividans, while mutational disruption of the absA locus results in precocious hyperproduction of actinorhodin and undecylprodigiosin in S. coelicolor A3(2) (3). The presumed functions of afsR, abaA, and absA, however, do not involve the ribosome.…”
Section: Discussionmentioning
confidence: 99%
“…The presumed functions of afsR, abaA, and absA, however, do not involve the ribosome. The activator gene from S. lividans is reported to encode an 86-nucleotide transcript, and this may act as an antisense RNA, blocking synthesis of a putative repressor protein (47). A tetracycline-resistant mutant of Streptomyces granaticolor has been reported to overproduce (twofold) granaticins (52).…”
Section: Discussionmentioning
confidence: 99%
“…In Streptomyces lividans, a species closely related to S. coelicolor, all of the genetic components for actinorhodin biosynthesis have also been identified, but actinorhodin is not produced under usual growth conditions (32). Because of this trait, the focus of study in this strain has been on how actinorhodin biosynthesis is initiated and regulated.…”
mentioning
confidence: 99%