Activation of xanthine oxidase by 1,4-naphthoquinones: A novel potential research topic for diet management and risk assessment

Liang, Sisi; Liu, Li; He, Bing; Zhao, Wei; Zhang, Wei; Xiao, Lihua; Deng, Mingming; Zhong, Xiaofeng; Zeng, Su; Qi, Xiaoyi; Lü, Muhan

doi:10.1016/j.foodchem.2023.136264

Cited by 3 publications

(1 citation statement)

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“…Moreover, the natural 1,4-naphtoquinone substances exhibited a broad spectrum of activity, such as anticancer, antibacterial, antiviral, and antimalarial. The low solubility and toxicity of natural compounds caused us to obtain synthetic compounds with 1,4-quinolinedione scaffold [ 6 , 13 , 16 , 17 ]. Modifying 1,4-naphthoquinone moiety at the C2 and C3 positions leads to obtaining a new compound with high biological activity.…”

Section: Introductionmentioning

confidence: 99%

Hybrids of 1,4-Naphthoquinone with Thymidine Derivatives: Synthesis, Anticancer Activity, and Molecular Docking Study

Kadela-Tomanek,

Krzykawski,

Halama

et al. 2023

Molecules

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One of the most essential health problems is cancer, the first or second cause of death worldwide. Head and neck cancers are hard to detect due to non-specific symptoms. The treatment often relies on a combination of radio and chemotherapy. For this reason, the research of new anticancer compounds is fundamental. The natural and synthetic compounds with 1,4-naphthoquinone scaffold is characterized by high anticancer activity. The study aimed to evaluate the synthesis and anticancer activity of hybrids 1,4-naphthoquinone with thymidine derivatives. The series of compounds allows us to check the influence of the substituent in the C3′ position of the thymidine moiety on the cytotoxicity against squamous cancer cell lines (SCC-9 and SCC-25) and submandibular gland cancer (A-253). An annexin V/propidium iodide (PI) co-staining assay shows that derivatives cause the apoptotic in SCC-25 and A-253 cell lines. The molecular docking study examined the interaction between the active site of the BCL-2 protein and the hybrids.

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