Active Coxsackieviral B Infection Is Associated With Disruption of Dystrophin in Endomyocardial Tissue of Patients Who Died Suddenly of Acute Myocardial Infarction

Andréoletti, Laurent; Ventéo, Lydie; Douche-Aourik, Fatima; Canas, Frédéric; Grandmaison, Geoffroy Lorin de la; Jacques, Jérôme; Moret, Hélène; Jovenin, Nicolas; Mosnier, Jean‐François; Matta, Mathieu; Duband, S.; Pluot, M; Pozzetto, Bruno; Bourlet, Thomas

doi:10.1016/j.jacc.2007.07.080

Cited by 61 publications

(42 citation statements)

References 31 publications

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“…A surveillance study of SCD from Ireland concluded that the majority of cases occurred in home and that successful resuscitation of SCD was especially associated with ventricular fibrillation as presenting rhythm (95). A recent study reported evidence for the occurrence of active Coxsackie B viral infections in people who died of MI compared to controls, and the authors suggested that an underlying mechanism might be disruption of dystrophin in endomyocardial tissue (96).…”

Section: Sudden Cardiac Death (Scd)mentioning

confidence: 99%

Epidemiology of coronary heart disease and acute coronary syndrome

Sanchís-Gomar¹,

Pérez-Quilis²,

Leischik³

et al. 2016

Ann. Transl. Med.

997

617

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The aim of this review is to summarize the incidence, prevalence, trend in mortality, and general prognosis of coronary heart disease (CHD) and a related condition, acute coronary syndrome (ACS). Although CHD mortality has gradually declined over the last decades in western countries, this condition still causes about one-third of all deaths in people older than 35 years. This evidence, along with the fact that mortality from CHD is expected to continue increasing in developing countries, illustrates the need for implementing effective primary prevention approaches worldwide and identifying risk groups and areas for possible improvement.

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Section: Sudden Cardiac Death (Scd)mentioning

confidence: 99%

Epidemiology of coronary heart disease and acute coronary syndrome

Sanchís-Gomar¹,

Pérez-Quilis²,

Leischik³

et al. 2016

Ann. Transl. Med.

997

617

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“…This sensitivity of detection, is crucial because TD mutants replicate slowly and to low titers (7,10,11). This will be important for future work and may explain past inability to detect RNA despite viral capsid protein VP1 detection (1).…”

mentioning

confidence: 99%

Quantitative Genomic and Antigenomic Enterovirus RNA Detection in Explanted Heart Tissue Samples from Patients with End-Stage Idiopathic Dilated Cardiomyopathy

Lévêque¹,

Renois²,

Talmud³

et al. 2012

J Clin Microbiol

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Standardized one-step real-time RT-PCR assay detected enterovirus RNA in cardiac biopsy samples from 4 of 20 patients suffering from idiopathic dilated cardiomyopathy (IDCM). The median viral load was 287 copies per microgram of total extracted nucleic acids, with positive- to negative-strand RNA ratios ranging from 2 to 20. These results demonstrate enterovirus persistence in the heart of IDCM patients, characterized by low viral loads and low positive- to negative-RNA ratios.

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“…Such hinge regions have been correlated with efficacy of the engineered minidystrophin construct in mouse models of DMD [9]. As well, specific protease sensitivity sites in dystrophin have been linked to various pathologies involving viral infection and heart attack [24,25].…”

Section: Discussionmentioning

confidence: 99%

Stability of dystrophin STR fragments in relation to junction helicity

Mirza

Menhart

2008

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Dystrophin is a rod shaped protein consisting of amino-and carboxy-terminal binding domains linked by a large central rod composed of 24 homologous copies of the STR motif and 4 nonhomologous regions termed hinges. These hinges are proposed to confer local flexibility; conversely, the tacit implication is that the STR regions away from the hinges are comparatively rigid. This, and the repeating nature of this rod, has contributed to the view that the STR region of the rod is uniform and monolithic. However, we have produced various 2 STR fragments, chosen to have high and low α-helix content at their junctions with each other, and show that they exhibit markedly different stabilities. In contrast to a related protein, spectrin, these differences are not correlated with the calculated helicity, but appear to be an intrinsic property of the motifs themselves. A full understanding of how these properties vary along the length of the rod has implications for the engineering of these rods regions in exon-skipping and mini-dystrophin therapies.

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Active Coxsackieviral B Infection Is Associated With Disruption of Dystrophin in Endomyocardial Tissue of Patients Who Died Suddenly of Acute Myocardial Infarction

Cited by 61 publications

References 31 publications

Epidemiology of coronary heart disease and acute coronary syndrome

Epidemiology of coronary heart disease and acute coronary syndrome

Quantitative Genomic and Antigenomic Enterovirus RNA Detection in Explanted Heart Tissue Samples from Patients with End-Stage Idiopathic Dilated Cardiomyopathy

Stability of dystrophin STR fragments in relation to junction helicity

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