Roll‐to‐Roll (R2R) manufacturing is changing how state‐of‐the‐art technology is made. Roll‐to‐Roll is part of a family of advanced scalable inline manufacturing techniques that make traditional and state‐of‐the‐art products at high yield and reduced cost. R2R manufacturing has grown rapidly and is fundamental to several advanced technologies such as functional materials and films, sensors for medicine, biology, and environment monitoring, energy harvesting devices, and flexible electronics. Advantages of R2R manufacturing include ease of machine design, adaptability to a wide range of additive processing methods, and very high throughput. To keep up with advances in R2R manufacturing, novel methods have emerged to measure important product metrics (thickness, roughness, conductivity) and monitor quality (uniformity, defects) inline and in real‐time. This review provides an overview of the state‐of‐the‐art for real‐time inline metrology and quality control in modern R2R manufacturing. The survey considers both established inline metrology techniques such as line‐scan imaging and reflectometry, and techniques recently adapted or that show promise for real‐time inline R2R metrology such as ellipsometry, hyper‐spectral imaging, and Raman spectroscopy.