Active-iron-promoted hydrodehalogenation of organic halides

Iron‐Catalyzed Substitution Reactions

“…The most prominent area of application of these complexes is the cross-coupling chemistry. The dehalogenation of aromatic halides using catalytic amounts of Fe salts and a reducing agent such as lithium powder is mechanistically related and can be applied to a variety of different halogenated aromatic compounds [8]. AlkylGrignard reagents can also be used as reducing agents in this type of chemistry; however, this observation is in sharp contrast to the results obtained in Fe-catalyzed cross-coupling reactions (Scheme 7.5) [9].…”

C−F Bond Activation in Organic Synthesis

“…Yus et al have systematically investigated the arene-catalyzed lithiation protocols; a combination of lithium powder and a catalytic amount of arene (naphthalene or 4,4′-di- tert -butylbiphenyl) is effective for reductive lithiation of organic halides at low temperature. The arene-catalyzed halogen−lithium exchange procedure works well for fluorobenzene ( 1 ) to generate phenyllithium, which readily reacts with a variety of electrophiles (Scheme ) …”

Highly selective copper nanoparticles for the hydrogenation of α,β-unsaturated aldehydes in liquid phase

“…This previous result, along with the consideration of the low cost of copper, encouraged us to further study this metal as a catalyst for selective hydrogenation reactions. Unsupported Ni, Fe and Cu nanoparticles, synthesized by chemical reduction of the corresponding metal (II) chloride with lithium sand and an arene as electron carrier, are quite interesting systems [13][14][15]. These unsupported nanoparticles (NPs) are uniform in size (3.0 ± 1.5 nm) and posses no protective agent.…”