The present paper deals with the challenges of minorities in the Commonwealth of Independent States (CIS) of the former Union of the Soviet Socialist Republic (USSR) following its disintegration in 1991.It begins by outlining the origins of what constitute the politics of empowerment as ushered by the two main international organizations of the 20th Century as the League of Nations and the United Nations Organisations which were created in the aftermaths of the First and Second World Wars of 1914-18 and 1939-45 respectively witnessed failures due to the arbitrary demarcations and redrawing the Map of Eastern and Western Europe as well as those of Africa and Asian Continents suitable for the colonial ambitions of European imperialist actors. The article traces three different phases of interventions before the end of the Cold War, a clear statistical table of the composition of the newly independent states confronted with varieties of crisis which can link to the blink of another World War especially the cases of Moldova and Ukraine as case studies in this study having sporadic National Liberation Movements. In order to properly tackle this situation, a historical approach was deemed necessary by linking the question of empowering national minorities to the question of National Liberation Movements in Eastern Europe with specific cases indicated. This study ends by bringing out the estimated population of each of the newly independent states which was left behind with multi-ethnic and multi-racial in nature till the present 21st Century. That multi-culturally of the fifteen CIS have been the main causes of some of the sporadic social and political uprisings which the hyper-powers of the century uses it as an advantage to gain more preeminence which likely acts as dangerous threat to the blink of another global escalation as the cases of the Balkans and Poland during the first half of the 20th Century.