Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis

Bruynzeel-Koomen, C; Wichen, D.F. Van; Spry, C. J. F.; Venge, Per; Bruynzeel, P.L.B.

doi:10.1111/j.1365-2133.1988.tb01779.x

Cited by 204 publications

(112 citation statements)

References 18 publications

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“…tions could be induced by patch tests with environmental allergens (house-dust tnites, grass pollen) as a tnodel for this tnode of triggering AD (3,4,11,31), In these patients, as in LPRs, a significant infiltration of eosinophils in the skin was detected within 2-6 h. By means of monoclonal antibodies against eosinophil toxic proteins, it was shown that these eosinophils were preactivated and that most of their granule content was released into the surrounding tissue. Twenty-four hours after allergen challenge, eosinophils could be detected even in the epidermis.…”

Section: Eosinophils In Atopic Dermatitismentioning

confidence: 99%

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The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

Kapp

1993

Allergy

156

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Currently, there is a large body of evidence that atopic dermatitis (AD) has an Immunologic basis. Atopy‐specific helper T cells (Th2‐like T cells) may play a pathogenetic role by producing and releasing cytokines relevant for the allergic inflammation, such as IL‐4, IL‐5, and other growth factors. Eosinophils are believed to be of major importance as effector cells mediating the pathogenetically relevant late‐phase reaction which is associated with a significant destruction of the surrounding tissue. Accordingly, a significant preactivation of peripheral blood eosinophils was detected in AD patients, leading to an enhanced susceptibility of these cells to distinct stimuli such as IL‐5. Toxic proteins, such as eosinophil cationic protein (ECP), contained in the matrix and the core of secondary granules of eosinophils, may play an important role by propagating the allergic inflammatory process and by modulating the immune response. The pathogenetic role of eosinophils in AD is further supported by the detection of these proteins in the eczematous skin of patients. Furthermore, recent data point to a significant correlation between disease activity and deposition of eosinophil granule content: ECP serum levels were significantly increased in AD patients. In addition, ECP levels correlated with the disease activity. Moreover, clinical improvement was associated with a decrease of both the clinical score and serum ECP levels. These data clearly indicate that activated eosinophils may play a major role in the allergic inflammatory process of AD. Therefore, modulation of eosinophil activation could prove to be an important pharmacologic modality for the treatment of AD.

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Section: Eosinophils In Atopic Dermatitismentioning

confidence: 99%

“…As demonstrated by several groups in a number of patients, environmental allergens, e.g. those of grass pollen and house-dust mites, induce eczematous reactions when applied to the skin (4,11,31). Moreover, it was shown that skin contact with these allergens may result in a general exacerbation of AD (1,5,17,26,36).…”

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confidence: 99%

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

Kapp

1993

Allergy

156

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“…It has been speculated that immediately after PT some allergens penetrate the epidermis, bind the IgE molecules on mast cells in the dermis and induce an immediate type reaction. Mast cell release eosinophil chemotactic factors and some of the infiltrating eosinophils become activated [41]. As already discussed, recent studies demonstrated that in the skin lesions of AD patients' Der pl-specific T clones are Th2 lymphocytes expressing IL-4 and IL-5 and no IFN-α (42).…”

Section: The Role Of Inhalant Allergensmentioning

confidence: 85%

“…Bruijnzeel-Koomen et al showed 70% positive PT response, applying house dust mite and pollen allergens on the back of AD adult patients, previously removing the superficial stratum corneum by consecutive application of adhesive tape [41]. No positive responses were found in atopic patients without AD or in controls.…”

Section: The Role Of Inhalant Allergensmentioning

confidence: 99%

Atopic Dermatitis and Allergen Hypersensitivity: State of the Art

Cantani¹

2016

J Ped Moth Care

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The current growing enthusiasm for atopic dermatitis is clearly reflected in the range of current attitudes on the subject. What are considered to be its protean manifestations are frequent challenges to the pediatrician and other specialists working with children. AD may occur not only in man, but also in other vertebrates. However, it must be assumed that AD has always been an affection of our species. Hippocrates (460-370 BC) reported urticaria and gastrointestinal upset following cow's milk ingestion. Lucretius (98-55 BC) wrote that one man's meat is another man's poison. Galen (131-219) described allergy to goat's milk. At the turn of this century the first description of acute shock due to CM allergy (CMA) and fatal CMA were published. In his pioneer studies of food allergy (FA), Schloss was the first to evaluate skin tests for the diagnosis of FA. Since then, a vast array of symptoms and disorders has been attributed to FA, many of which occur with other conditions. In addition to this, the lack of a single, practical diagnostic test has contributed to the polarization of the scientific controversy between those who believe in and those who deny FA existence. Terminology has also been confusing. A correct use of definitions is necessary for a proper epidemiologic evaluation of the conditions and an accurate diagnostic and therapeutic approach. While this concept was fundamentally correct, it was also too easily weakened by ignoring this prerequisite to be fully acceptable, and this led to an equally disordered use of the term hypersensitivity, since allergy had become a word used to embrace all possible forms of adverse reactions. AD is associated with patchy, characteristically distributed areas of cutaneous eczema, with intense itching and subsequent lichenification of the skin. Cutaneous automic dysfunction (increased vasoconstriction) and xerosis (dryness of the skin) commonly occur in the affected children. In addition, profound immunological dysregulation with various immune alterations has been described in affected children. Most children produce IgE antibodies to a number of food and inhalants allergens, at the point that a minuscule offending quantity can trigger a reaction by skin contact or by inhalation.

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“…Increased serum levels of MBP (97) and ECP (98), and deposits of MBP in lesional skin (74) occur in patients with AD. Moreover, cutaneous eosinophils are present in positive patch tests with specific aero-allergens in AD patients (99). The role of the eosinophils in AD is, however, unknown.…”

Section: Eosinophil-derived Toxic Proteinsmentioning

confidence: 99%

Pathophysiology of itching in urticaria and atopic dermatitis

Wahlgren

1992

Allergy

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Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis

Cited by 204 publications

References 18 publications

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

Atopic Dermatitis and Allergen Hypersensitivity: State of the Art

Pathophysiology of itching in urticaria and atopic dermatitis

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