Active Subjects with Autoimmune Type 1 Diabetes have Better Metabolic Profiles than Sedentary Controls

Ialacqua

Terruzzi³

et al. 2018

Endocrine

Physical activity, together with diet and pharmacological therapy, represents one of the three cornerstones in type 2 diabetes mellitus treatment and care. The therapeutic appeal of regular physical activity stems from: (i) its non-pharmacological nature; (ii) its beneficial effects on the metabolic risk factors associated with diabetes complications; (iii) its low costs. Evidence accumulated in the last years suggests that aerobic training-endurance training-constitutes a safe modality of intervention, achievable, and effective in diabetes treatment, whenever it is not limited by comorbidities. Aerobic training exerts insulin-mimetic effects and has been shown to lower mortality risk too. Anaerobic, intense physical activity, such as that of strength or power sports disciplines, is not univocally recognized as safe and simple to realize, however, it is important in stimulating energy and glucose metabolism. According to recent evidence, high-intensity training may be prescribed even in the face of cardiovascular diseases, peripheral vascular disease, or osteoarthritis. Some studies have shown resistance training to be more efficient than aerobic exercise in improving glycemic control. This review explores the most up-to-date indications emerging from literature in support of the beneficial effects of strength stimulation and resistance training in patients with type 2 diabetes without complications.

Section: Comprehensive Educational Programs In the Management And Carmentioning

confidence: 99%

May the force be with you: why resistance training is essential for subjects with type 2 diabetes mellitus without complications

Ialacqua

Terruzzi³

et al. 2018

Endocrine

“…In adults with T1D, we have conducted several studies showing the multifaceted positive effects of exercise on immunometabolism and autoimmunity [8,74,126,127].…”

Section: After Normalizing Bmi Diet Age Estaki Et Al Analyzed Fecmentioning

confidence: 99%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Digestive and Liver Disease

Luzi

Terruzzi³

2018

128

Please cite this article as: Codella Roberto, Luzi Livio, Terruzzi Ileana.Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases.Digestive and Liver Disease https://doi.org/10.1016/j.dld. 2017.11.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractLimited animal and human research findings implied that exercise might have a

“…In other longitudinal studies (observational and intervention) we showed that exercise may positively modulate immune system function in β-cells transplanted recipients. Active subjects with T1D, following islet transplantation (IT), exhibited ameliorated scores of disease management, quality of life [5], metabolic control, body composition [6]. In addition, in IT subjects, physical exercise was capable to counteract diabetic symptoms and mitigated the side effects of immunosuppressive drugs and graft dysfunction [7,8].…”

Section: Immunomodulatory Indications From Animal and Human Modelsmentioning

confidence: 99%

“…Likewise for individuals with T2D, physical activity should be embodied in the management of T1D as it increases insulin sensitivity (both short and long term), lowers blood glucose levels, reduces body fat (and ameliorates body mass composition [6]), improves cardiovascular function. However, due to the loss of the β-cell pancreatic mass and/or -function, subjects with T1D uniquely face a number of challenges in preparation for, during, and after each session of exercise.…”

Section: Exercise In T1d: the Risk-benefit Analysismentioning

confidence: 99%

See 1 more Smart Citation

Why should people with type 1 diabetes exercise regularly?

Terruzzi²,

Luzi

2017

Acta Diabetol

Plethoric evidence reminds of the protective effects of exercise against a number of health risks, across all ages, in the general population. The benefits of exercise for individuals with type 2 diabetes are indisputable. An in-depth understanding of energy metabolism has reasonably entailed exercise as a cornerstone in the lifestyle of almost all subjects with type 1 diabetes. Nevertheless, individuals with type 1 diabetes often fail in accomplishing exercise guidelines and they are less active than their peer without diabetes. Two major obstacles are feared by people with type 1 diabetes who wish to exercise regularly: management of blood glucose control and hypoglycemia. Nowadays, strategies, including glucose monitoring technology and insulin pump therapy, have significantly contributed to the participation in regular physical activity, and even in competitive sports, for people with type 1 diabetes. Novel modalities of training, like different intensity, interspersed exercise, are as well promising. The beneficial potential of exercise in type 1 diabetes is multi-faceted, and it has to be fully exploited because it goes beyond the insulin-mimetic action, possibly through immunomodulation.