Active surveillance of low-risk papillary thyroid carcinoma: a promising strategy requiring additional evidence

Ze, Yuyang; Zhang, Xiaowen; Shao, Fei; Zhu, Lin; Shen, Shanmei; Zhu, Dalong; Bi, Yan

doi:10.1007/s00432-019-03021-y

Cited by 12 publications

(10 citation statements)

References 49 publications

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“…In addition, we further validated the inhibitory effects of E2F1 knockout on PTC tumor growth in vivo , as evidenced by decreased Ki67 positive expression. The latter is particularly important as Ki67 positive expression is lauded as a critical indicator of PTC growth, since Ki67 was associated with tumor volume and thyroiditis and further associated with a high chance of relapse [ 34 , 35 ]. Furthermore, a prior study highlighted that Ki67 expression was elevated in conjunction with E2F1 overexpression in cervical cancer, which reiterates the positive relationship between them [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Yang

Ying

Zeng

et al. 2022

Analytical Cellular Pathology

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Background. Papillary thyroid carcinoma (PTC) is the most common thyroid neoplasm, whereas transcription factor E2F1 has been previously implicated in PTC progression. The current study sought to elucidate the underlying mechanism of E2F1 in PTC cell biological activities via regulation of long intergenic noncoding RNA 152 (LINC00152). Methods. Firstly, the expression patterns of LINC00152 and E2F1 in PTC were determined. Besides, TPC-1 and IHH-4 cells were adopted to carry out a series of experiments. Cell proliferation was detected by means of a cell counting kit-8 assay and colony formation assay, while cell migration and invasion abilities were assessed using a Transwell assay. Next, the interaction between E2F1 and LINC00152 was certified. Lastly, xenograft transplantation was carried out to validate the effects of E2F1 depletion on PTC. Results. Both LINC00152 and E2F1 were highly expressed in PTC cells. Knockdown of LINC00152 led to reduced cell activity, while LINC00152 overexpression brought about the opposing trends. Likewise, E2F1 knockdown quenched cell proliferation, migration, and invasion. However, the combination of E2F1 knockdown and LINC00152 overexpression resulted in augmented cell growth. In addition, E2F1 induced LINC00152 overexpression, which accelerated cell proliferation, migration, and invasion by activating the PI3K/AKT axis, whereas the administration of LY294002, the inhibitor of PI3K, led to reversal of the same. Finally, xenograft transplantation validated that E2F1 inhibition could suppress LY294002, thereby discouraging tumor growth. Conclusion. Our findings highlighted that E2F1 augmented PTC cell proliferation and invasion by upregulating LINC00152 and the PI3K/AKT axis. Our discovery provides therapeutic implications for PTC alleviation.

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Section: Discussionmentioning

confidence: 99%

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Yang

Ying

Zeng

et al. 2022

Analytical Cellular Pathology

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“…Detection of LNM on preoperative evaluation is critical in patients undergoing active surveillance management. Active surveillance management is the careful monitoring of patients with low-risk primary PTC (small size or without suspicious US features) by yearly or bi-yearly US and/or CT to detect thyroid nodule changes [ 60 ]. Importantly, LNM detection is an indication to immediately terminate active surveillance management and proceed with surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

Radiologist versus Non-Radiologist Detection of Lymph Node Metastasis in Papillary Thyroid Carcinoma by Ultrasound: A Meta-Analysis

et al. 2022

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Papillary thyroid carcinoma (PTC) is the most common thyroid cancer worldwide and is known to spread to adjacent neck lymphatics. Lymph node metastasis (LNM) is a known predictor of disease recurrence and is an indicator for aggressive resection. Our study aims to determine if ultrasound sonographers’ degree of training influences overall LNM detection. PubMed, Embase, and Scopus articles were searched and screened for relevant articles. Two investigators independently screened and extracted the data. Diagnostic test parameters were determined for all studies, studies reported by radiologists, and studies reported by non-radiologists. The total sample size amounted to 5768 patients and 10,030 lymph nodes. Radiologists performed ultrasounds in 18 studies, while non-radiologists performed ultrasounds in seven studies, corresponding to 4442 and 1326 patients, respectively. The overall sensitivity of LNM detection by US was 59% (95%CI = 58–60%), and the overall specificity was 85% (95%CI = 84–86%). The sensitivity and specificity of US performed by radiologists were 58% and 86%, respectively. The sensitivity and specificity of US performed by non-radiologists were 62% and 78%, respectively. Summary receiver operating curve (sROC) found radiologists and non-radiologists to detect LNM on US with similar accuracy (p = 0.517). Our work suggests that both radiologists and non-radiologists alike detect overall LNM with high accuracy on US.

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“…Axillary pain and numbness of the chin after conventional transoral endoscopic thyroidectomy are important reasons affecting the effect of surgery outcome [18,19] . More importantly, the nylon wire examination score, pressure needle puncture examination score, or numbness VAS score indicated that the degree of numbness of the jaw in novel Mini transoral endoscopic thyroidectomy group is signi cantly better than the conventional transoral endoscopic thyroidectomy group.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Application of Novel Mini Transoral Endoscopic Thyroidectomy to Avoid Numbness and Pain in Patients with Thyroidectomy

Ruan

Ning

et al. 2020

Preprint

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Background: Transoral endoscopic thyroidectomy has been gaining popularity as it allows patients to avoid a visible scar in the neck. However, there are still exiting disadvantages of traditional transoral endoscopic thyroidectomy，including numbness in the lower jaw or excessive edema. Therefore, we designed and applied a novel Mini transoral endoscopic thyroidectomy on patients requiring for thyroidectomy.Patients and Methods: A total of 55 patients requiring for unilateral thyroidectomy who underwent novel Mini transoral endoscopic thyroidectomy (Mini group) were identified from August 2019 to December 2019. As a comparison, a matched cohort of 55 patients requiring for conventional transoral endoscopic thyroidectomy was also identified. The two groups were analyzed in terms of clinical characteristics, perioperative/operative clinical date and post-operative complications. Results: The hospitalization time of patients in the Mini group was obviously less than that in traditional group. Furthermore, the numbness of the lower jaw, nylon wire examination score, pressure needle puncture examination score, or numbness VAS score indicated that the degree of numbness of the jaw in Mini group is significantly better than the traditional group. Moreover, the pain of the axillary incision using the pain VAS score method also showed that Mini group is significantly better than the traditional group. The results of pain of the axillary incision using the VAS score method also showed that novel Mini group was significantly better than that in the traditional group. Furthermore, dysfunction of mandibular muscles was observed in six of fifty-five patients in the traditional group, whereas no dysfunction of mandibular muscles observed in Mini group. At last, the degree of postoperative mandibular edema in Mini group was markedly slighter than that in traditional group. The post-operation infection rate was markedly lower in Mini group.Conclusion: The new novel Mini transoral endoscopic thyroidectomy is safe and feasible, and reduces the damage to the functional muscles such as the mandibular diaphragm and lower lip muscles, which significantly reduces the numbness and edema of the mandible after surgery. Our novel Mini transoral endoscopic thyroidectomy is a feasible and safe advancement, which can be a viable alternative protecting patients from insufferable numbness and pain.

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Active surveillance of low-risk papillary thyroid carcinoma: a promising strategy requiring additional evidence

Cited by 12 publications

References 49 publications

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Radiologist versus Non-Radiologist Detection of Lymph Node Metastasis in Papillary Thyroid Carcinoma by Ultrasound: A Meta-Analysis

The Clinical Application of Novel Mini Transoral Endoscopic Thyroidectomy to Avoid Numbness and Pain in Patients with Thyroidectomy

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