Activin from Secondary Follicles Causes Small Preantral Follicles to Remain Dormant at the Resting Stage

Mizunuma, Hideki; Liu, Xiaowei; Andoh, Kazumichi; Abe, Yumiko; Kobayashi, Junro; Yamada, Kiyohiko; Yokota, Hiromi; Ibuki, Yoshito; Hasegawa, Yoshihisa

doi:10.1210/endo.140.1.6409

Cited by 65 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…but had no effect on immature follicles, whereas activin treatment had the opposite effect (212). Activin from secondary follicles may even inhibit growth of smaller follicles (213). Collectively, these studies demonstrate that activin has a variety of growth-promoting actions in immature follicles consistent with findings from granulosa cell culture studies (191).…”

Section: Regulation Of Ovarian Follicular Developmentsupporting

confidence: 64%

Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium

Welt

Sidis²,

Keutmann

et al. 2002

Exp Biol Med (Maywood)

298

275

View full text Add to dashboard Cite

It has been 70 years since the name inhibin was used to describe a gonadal factor that negatively regulated pituitary hormone secretion. The majority of this period was required to achieve purification and definitive characterization of inhibin, an event closely followed by identification and characterization of activin and follistatin (FS). In contrast, the last 15–20 years saw a virtual explosion of information regarding the biochemistry, physiology, and biosynthesis of these proteins, as well as identification of activin receptors, and a unique mechanism for FS action—the nearly irreversible binding and neutralization of activin. Many of these discoveries have been previously summarized; therefore, this review will cover the period from the mid 1990s to present, with particular emphasis on emerging themes and recent advances. As the field has matured, recent efforts have focused more on human studies, so the endocrinology of inhibin, activin, and FS in the human is summarized first. Another area receiving significant recent attention is local actions of activin and its regulation by both FS and inhibin. Because activin and FS are produced in many tissues, we chose to focus on a few particular examples with the most extensive experimental support, the pituitary and the developing follicle, although nonreproductive actions of activin and FS are also discussed. At the cellular level, it now seems that activin acts largely as an autocrine and/or paracrine growth factor, similar to other members of the transforming growh factor β superfamily. As we discuss in the next section, its actions are regulated extracellularly by both inhibin and FS. In the final section, intracellular mediators and modulators of activin signaling are reviewed in detail. Many of these are shared with other transforming growh factor β superfamily members as well as unrelated molecules, and in a number of cases, their physiological relevance to activin signal propagation remains to be elucidated. Nevertheless, taken together, recent findings suggest that it may be more appropriate to consider a new paradigm for inhibin, activin, and FS in which activin signaling is regulated extracellularly by both inhibin and FS whereas a number of intracellular proteins act to modulate cellular responses to these activin signals. It is therefore the balance between activin and all of its modulators, rather than the actions of any one component, that determines the final biological outcome. As technology and model systems become more sophisticated in the next few years, it should become possible to test this concept directly to more clearly define the role of activin, inhibin, and FS in reproductive physiology.

show abstract

Section: Regulation Of Ovarian Follicular Developmentsupporting

confidence: 64%

Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium

Welt

Sidis²,

Keutmann

et al. 2002

Exp Biol Med (Maywood)

298

275

View full text Add to dashboard Cite

show abstract

“…However, there is no good evidence to show that this is a continuous period of growth; indeed, it is likely that follicles grow in vivo in a 'start-stop' manner in response to local influences. This hypothesis is supported by studies showing that advanced-stage follicles can arrest the growth of follicles at the pre-antral stage without compromising their subsequent ability to proceed further (Mizunuma et al, 1999). Studies on the underlying molecular mechanisms regulating the initiation of follicle development (Foxo3 and Pten knockout studies) have shown that despite global activation of follicles, the rate at which follicles develop differs (i.e.…”

Section: Growing Human Oocytes From Primordial Folliclesmentioning

confidence: 95%

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation

Smitz¹,

Dolmans

Donnez

et al. 2010

Human Reproduction Update

280

204

View full text Add to dashboard Cite

BACKGROUND Female cancer patients are offered 'banking' of gametes before starting fertility-threatening cancer therapy. Transplants of fresh and frozen ovarian tissue between healthy fertile and infertile women have demonstrated the utility of the tissue banked for restoration of endocrine and fertility function. Additional methods, like follicle culture and isolated follicle transplantation, are in development. METHODS Specialist reproductive medicine scientists and clinicians with complementary expertise in ovarian tissue culture and transplantation presented relevant published literature in their field of expertise and also unpublished promising data for discussion. As the major aims were to identify the current gaps prohibiting advancement, to share technical experience and to orient new research, contributors were allowed to provide their opinioned expert views on future research. RESULTS Normal healthy children have been born in cancer survivors after orthotopic transplantation of their cryopreserved ovarian tissue. Longevity of the graft might be optimized by using new vitrification techniques and by promoting rapid revascularization of the graft. For the in vitro culture of follicles, a successive battery of culture methods including the use of defined media, growth factors and three-dimensional extracellular matrix support might overcome growth arrest of the follicles. Molecular methods and immunoassay can evaluate stage of maturation and guide adequate differentiation. Large animals, including non-human primates, are essential working models. CONCLUSIONS Experiments on ovarian tissue from non-human primate models and from consenting fertile and infertile patients benefit from a multidisciplinary approach. The new discipline of oncofertility requires professionalization, multidisciplinarity and mobilization of funding for basic and translational research.

show abstract

“…Ovarian mediators with an inhibiting action include activin A and AMH. Activin A is secreted by larger follicles, and in mice it causes small pre-antral follicles to become dormant (Mizunuma et al 1999). In male foetuses, AMH is responsible for regression of the paramesonephric ducts (Mu¨llerian ducts), from which the oviducts, uterus, cervix and cranial part the vagina are derived.…”

Section: Primordial Follicle Activationmentioning

confidence: 99%

Ovarian Follicular Dynamics: A Review with Emphasis on the Bovine Species. Part I: Folliculogenesis and Pre‐antral Follicle Development

Aerts

Bols

2010

Reprod Domestic Animals

View full text Add to dashboard Cite

Recent scientific research into pre-antral follicular dynamics has resulted in the discovery of a wide range of hormones and local factors that influence primordial follicle activation and contribute to follicular development. The putative role of several of these mediators in the follicle growth process has been elucidated by genetic and molecular investigations. Crucial questions, such as the mechanism for primordial follicle initiation and the interplay between oocyte and granulosa cells in this process, remain however unresolved. This review article commences with a description of the embryogenesis of the ovary and follicles. Next, the different stages in the development from primordial to pre-antral follicle are discussed. Thereafter, a short overview of the various in vitro models for the study of follicular dynamics is presented. Finally, an in-depth discussion of pre-antral follicle development engages in the current hypotheses regarding primordial follicle activation, and the role of gonadotrophins and angiogenesis.

show abstract

Activin from Secondary Follicles Causes Small Preantral Follicles to Remain Dormant at the Resting Stage

Cited by 65 publications

References 27 publications

Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium

Activins, Inhibins, and Follistatins: From Endocrinology to Signaling. A Paradigm for the New Millennium

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation

Ovarian Follicular Dynamics: A Review with Emphasis on the Bovine Species. Part I: Folliculogenesis and Pre‐antral Follicle Development

Contact Info

Product

Resources

About