Trans and nonbinary (TNB) individuals cope with gender-related stress in unique ways that are not captured in existing coping measures. The present research extends prior qualitative research on these unique coping strategies to develop and validate the Trans and Nonbinary Coping Measure (TNCM). The initial developed pool of potential items was presented to two focus groups and five content experts for review. In Study 1 (N = 298), the 166 initial items hypothesized to underly an eight-factor structure were analyzed using exploratory and confirmatory factor analysis (EFA, CFA). Results from the EFA and CFA revealed a six-factor structure as the best fit with 130 items removed. Study 1 also provided preliminary construct and discriminant validity due to significant correlations between the TNCM and an existing measure of coping and nonsignificant relations with a measure of self-motivation. In Study 2 (N = 497), an independent sample of TNB participants was recruited and findings from CFA analysis indicated that the removal of an additional 8 items was statistically optimal. With the removal of these eight items, configural, metric, and partial scalar invariance between TNB gender identity groups was supported. Additionally, results from Study 2 further supported construct and predictive validity through correlations between the TNCM and measures of gender minority stress and mental health outcomes. Finally, Study 3 (N = 35) provided support for test–retest reliability with a third independent sample of TNB participants. Across the studies, the TNCM was found to be a valid measure of TNB specific ways of coping.