Activities of neurons within the rat dorsolateral septal nucleus (DLSN)

Gallagher, Joel P.; Zheng, Fang; Hasuo, Hiroshi; Shinnick‐Gallagher, Patricia

doi:10.1016/0301-0082(95)98600-a

Cited by 76 publications

(64 citation statements)

References 133 publications

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“…Furthermore, DA (30 M) directly depressed the fast IPSP in monosynaptic GABAergic pathway. Such an inhibition of GABAergic transmission may consequently enhance the EPSP under physiological condition because the fast IPSP has been known to overlap with the EPSP in DLSN neurons (Gallagher et al 1995). DA did not affect the I GABA produced by direct application of GABA to the neurons.…”

Section: Inhibition Of Gabaergic Transmission By Damentioning

confidence: 90%

“…These results suggest that DA (10 -30 M) inhibits the IPSP by reducing evoked and spontaneous release of GABA in DLSN neurons. Previously, electrophysiological and morphological studies have shown that stimulation of the fimbria appears to evoke both feedforward and feedback IPSPs in DLSN (Gallagher et al 1995). Although there is no direct evidence to support the existence of any classical interneuron in the lateral septum, previous data have indicated the presence of "functional" GABAergic local circuit within the DLSN (Phelan et al 1989).…”

Section: Inhibition Of Gabaergic Transmission By Damentioning

confidence: 96%

“…1B). The fast IPSP partially overlaps with both the EPSP and slow IPSP in DLSN neurons (Gallagher et al 1995). To examine the effects of DA on the EPSP and slow IPSP, the fast IPSP was blocked by bicuculline (15 M), a GABA A receptor antagonist (Fig.…”

Section: R E S U L T Smentioning

confidence: 99%

“…It has been shown that the fast and slow IPSPs were disynaptically mediated by GABA because GABAergic projection neurons are innervated by glutamatergic excitatory nerve inputs via the fimbria/fornix pathway (Gallagher et al 1995;Hasuo et al 1992;Jakab and Leranth 1995). To examine the direct effect of DA on GABAergic transmission, the monosynaptic fast IPSP was recorded from DLSN neurons, where the EPSP and slow IPSPs were blocked by DNQX (20 M), AP5 (50 M), and CGP 55845 (4 M) (Hasuo et al 2002).…”

Section: Presynaptic Inhibition Of the Fast Ipsp In Monosynaptic Gabamentioning

confidence: 99%

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Dopamine Presynaptically Depresses Fast Inhibitory Synaptic Transmission via D4 Receptor-Protein Kinase A Pathway in the Rat Dorsolateral Septal Nucleus

Asaumi

Hasuo

Akasu³

2006

Journal of Neurophysiology

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Asaumi, Yasuo, and Hiroshi Hasuo, and Takashi Akasu. Dopamine presynaptically depresses fast inhibitory synaptic transmission via D4 receptor-protein kinase A pathway in the rat dorsolateral septal nucleus. J Neurophysiol 96: 591-601, 2006. First published April 26, 2006 doi:10.1152/jn.00966.2005. The lateral septal nucleus receives a diffuse dopaminergic input originating from the ventral tegmental area of the brain stem. We examined whether dopamine (DA) modulates synaptic transmission in the slice preparation of the rat dorsolateral septal nucleus (DLSN). Bath application (10 -15 min) of DA (30 M) markedly depressed the amplitude of fast and slow inhibitory postsynaptic potentials (IPSPs) in DLSN neurons, while it produced only a minor depression of the amplitude of excitatory postsynaptic potentials (EPSPs) obtained in the presence of bicuculline. DA (30 M) depressed the monosynaptic fast IPSP to ϳ50% of control, but did not depress the inward current (I GABA ) induced by exogenous ␥-aminobutyric acid (GABA). DA decreased the frequency of miniature fast IPSPs (m-fIPSPs) without significantly changing their amplitude. PD 168077, a selective D4 receptor agonist, depressed the fast and slow IPSPs but not the EPSP and decreased the frequency of m-fIPSPs. Both DA and PD 168077 increased the paired-pulse ratio of the monosynaptic fast IPSP. The inhibitory effect of DA on the fast IPSP was significantly attenuated by L-741,742, an antagonist at D4 receptors, but not by SCH 23390 and sulpiride, a D1-like and a D2-like receptor antagonist, respectively. N-ethylmaleimide, a blocker of pertussis toxin (PTX)-sensitive G protein (G i/o ), attenuated the DA-induced depression of the fast IPSP. N- [2-((p-bromocinnamyl) amino)ethyl]-5-isoquinoline sulfonamide, a protein kinase A (PKA) inhibitor, attenuated the DA-induced depression of the fast IPSP. These results suggest that DA inhibits spontaneous and evoked release of GABA via the D4 receptor-G i -protein-PKA system in DLSN neurons.

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Section: Inhibition Of Gabaergic Transmission By Damentioning

confidence: 90%

Section: Inhibition Of Gabaergic Transmission By Damentioning

confidence: 96%

Section: R E S U L T Smentioning

confidence: 99%

Section: Presynaptic Inhibition Of the Fast Ipsp In Monosynaptic Gabamentioning

confidence: 99%

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Dopamine Presynaptically Depresses Fast Inhibitory Synaptic Transmission via D4 Receptor-Protein Kinase A Pathway in the Rat Dorsolateral Septal Nucleus

Asaumi

Hasuo

Akasu³

2006

Journal of Neurophysiology

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“…Neurons in the dorsolateral nucleus (DLSN) receive massive glutamatergic nerve inputs from hippocampal CA1 and CA3 pyramidal neurons through the fimbria/fornix pathway [12,13]. Stimulation of these neurons evokes EPSP in the DLSN neurons [14,15]. Principal neurons in the DLSN which contain ␥-aminobutyric acid (GABA) not only send afferents to hypothalamic and amygdaloid areas but also participate in local inhibitory circuits within the lateral septum mediating the IPSP via their local axon Key words: corticosteroids, lateral septum, presynaptic inhibition, IPSP, GABA-release.…”

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confidence: 99%

Effects of Corticosteroids on Synaptic Transmission in Rat Dorsolateral Septal Nucleus.

Tsurusaki

Akasu²

2000

JJP

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It has been reported that endogenous steroids synthesized de novo in neurons of the central nervous system (CNS) modulate the neuronal activity of neurons in the CNS in terms of a nongenomic way [1][2][3][4][5][6][7]. Histological and binding studies revealed receptors or binding sites for neuroactive steroids in the membrane of neurons of the limbic structures such as hippocampus, septal nuclei and amygdala [8][9][10]. However, there are some differences in the actions of corticosteroids on synaptic transmission in the hippocampus. Neuronal excitability was reduced by corticosterone in hippocampal pyramidal neurons [4]. Zeise et al. [7] showed that corticosterone depressed inhibitory postsynaptic potentials (IPSPs) without affecting the fast excitatory postsynaptic potential (EPSP) in hippocampal and neocortical neurons. On the other hand, dehydroepiandrosterone, a neurosteroid, enhanced the EPSP in hippocampal CA1 pyramidal neurons [11].The lateral septum belongs to the limbic system that participates in a variety of physiological and behavioral functions related to learning, memory and emotions (fear and aggression), as well as autonomic regulation. Neurons in the dorsolateral nucleus (DLSN) receive massive glutamatergic nerve inputs from hippocampal CA1 and CA3 pyramidal neurons through the fimbria/fornix pathway [12,13]. Stimulation of these neurons evokes EPSP in the DLSN neurons [14,15]. Principal neurons in the DLSN which contain ␥-aminobutyric acid (GABA) not only send afferents to hypothalamic and amygdaloid areas but also participate in local inhibitory circuits within the lateral septum mediating the IPSP via their local axon Key words: corticosteroids, lateral septum, presynaptic inhibition, IPSP, GABA-release. Abstract:The effects of corticosteroids on synaptic transmission in the rat dorsolateral septal nucleus (DLSN) were examined, in vitro, by using intracellular and voltage-clamp recording methods. Prednisolone (100 M) increased the amplitude of excitatory postsynaptic potential (EPSP) and depressed both fast and slow inhibitory postsynaptic potentials (IPSP). Under voltage-clamp conditions, prednisolone (100 M) increased the amplitude of excitatory postsynaptic current (EPSC) and depressed the fast and slow inhibitory postsynaptic currents (IPSCs). Corticosterone (100 M) mimicked the effects of prednisolone on the postsynaptic currents (PSCs). To examine the direct effects of prednisolone on the EPSC and slow IPSC, the fast IPSC was blocked by bicuculline (20 M). Under these experimental conditions, prednisolone (100 M) did not alter the isolated EPSC but depressed slow IPSC by 22Ϯ3% (nϭ10). The fast IPSC was isolated by pretreatment with kynurenic acid and CGP55845A, where the EPSC and slow IPSC were blocked. Prednisolone (100 M) depressed the isolated fast IPSC in DLSN neurons. Prednisolone (100 M) did not change either the inward current produced by glutamate or the outward current produced by ␥-aminobutyric acid (GABA). The results suggest that corticosteroids facilitate excitatory synapti...

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Projections of the median raphe nucleus in the rat

1999

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No previous report in any species has examined comprehensively the projections of the median raphe (MR) nucleus with modern tracing techniques. The present report represents an in depth analysis of the projections of MR by use of the anterograde anatomical tracer Phaseolus vulgaris‐leucoagglutinin. MR fibers descend along the midline within the brainstem and mainly ascend within the medial forebrain bundle in the forebrain. MR fibers distribute densely to the following brainstem/forebrain sites: caudal raphe nuclei, laterodorsal tegmental nucleus, dorsal raphe nucleus, interpeduncular nucleus, medial mammillary body, supramammillary nucleus, posterior nucleus and perifornical region of the hypothalamus, midline and intralaminar nuclei of thalamus, dopamine‐containing cell region of medial zona incerta, lateral habenula, horizontal and vertical limbs of the diagonal band nuclei, medial septum, and hippocampal formation. Virtually all of these structures lie on or close to the midline, indicating that the MR represents a midline/para‐midline system of projections. Overall, MR projections to the cortex are light. MR projects moderately to the perirhinal, entorhinal and frontal cortices, but sparingly to remaining regions of cortex. A comparison of MR with dorsal raphe (DR) projections (Vertes RP. 1991. J Comp Neurol 313:643–668) shows that these two major serotonin‐containing cell groups of the midbrain distribute to essentially nonoverlapping regions of the forebrain; that is, the MR and DR project to complementary sites in the forebrain. A direct role for the MR in the desynchronization of the electroencephalographic activity of the hippocampus and its possible consequences for memory‐associated functions of the hippocampus is discussed. J. Comp. Neurol. 407:555–582, 1999. © 1999 Wiley‐Liss, Inc.

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Activities of neurons within the rat dorsolateral septal nucleus (DLSN)

Cited by 76 publications

References 133 publications

Dopamine Presynaptically Depresses Fast Inhibitory Synaptic Transmission via D4 Receptor-Protein Kinase A Pathway in the Rat Dorsolateral Septal Nucleus

Dopamine Presynaptically Depresses Fast Inhibitory Synaptic Transmission via D4 Receptor-Protein Kinase A Pathway in the Rat Dorsolateral Septal Nucleus

Effects of Corticosteroids on Synaptic Transmission in Rat Dorsolateral Septal Nucleus.

Projections of the median raphe nucleus in the rat

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