Activities of newer β-Lactam antibiotics agsinst ampicillin, chloramphenicol, or multiply-resistant Haemophilus influenzae

Antibiotic Susceptibility of Haemophilus Influenzae Isolated From Cerebrospinal Fluid and Blood

“…In our study the most active antibiotics were ceftriaxone followed by cefotaxime, moxalactam and aztreonam. This result was in good agreement with the investigation by Strandberg et al (23). These antibiotics were equally active against 0-lactamase producing and non-producing strains.…”

“…Several of the newer cephalosporins have been reported to show a high in vitro activity against clinically relevant H. influenzae isolates (9, 17,23). Furthermore, strains resistant to both ampicillin and chloramphenicol appear to be susceptible to some of the third generation cephalosporins (23). The present study confirmed these results with respect to the high activity of several of the newer J3-lactam antibiotics against both p-lactamase producing and non-producing H. influenzae strains.…”

“…Several of the newer cephalosporins have been reported to show a high in vitro activity against clinically relevant H. influenzae isolates (9, 17,23). Furthermore, strains resistant to both ampicillin and chloramphenicol appear to be susceptible to some of the third generation cephalosporins (23).…”

Disk diffusion interpretive criteria for extended-spectrum cephalosporins with Haemophilus influenzae

“…In Haemophilus influenza clinical isolates, resistance to conventional antimicrobial agents used to treat serious systemic infections, e.g., ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole, has increased (2,3,6,9). Because of this, several newer extended-spectrum cephalosporins have been proposed as effective therapeutic alternatives (1,4,7,8,11,(13)(14)(15). However, disk diffusion interpretive zone sizes for these agents have not been described specifically for tests with H. influenza.…”

Comparative activities of LY 164846 and other orally administered beta-lactam antibiotics against Haemophilus influenzae

“…influenzae has shown increasing resistance to a number of parenteral and orally administered antimicrobial agents in recent years (1,3,5,6,9). While several newer P-lactam antibiotics appear promising for therapy of life-threatening H. influenzae infections (2,10,12), few orally administered agents have been available for treatment of resistant isolates causing respiratory infections in ambulatory patients (4,7).…”