Activity and chronopharmacology of very low doses of physiological immune inducers

Bastide, M.; Doucet-Jaboeuf, M.; Daurat, Véronique

doi:10.1016/0167-5699(85)90007-6

Cited by 29 publications

(12 citation statements)

References 2 publications

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“…42 The reduction of inter-digital skin thickness in thymulin 5cH treated birds was accompanied by reduction of cell migration in the inoculation site. This result agrees with that obtained by Bastide et al, 17,43 in which high diluted Development of broiler chickens: a zoo technical approach C Sato et al thymulin decreased thymus-dependent lymphocyte response in new zeland black mice (NZB). In addition, the anti-inflammatory effect of pharmacological thymulin is also known.…”

Section: Discussionsupporting

confidence: 92%

Development of broiler chickens after treatment with thymulin 5cH: a zoo technical approach

2012

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Modulation of immune response due to thymulin 5cH has been previously observed. The aim of the present study is to evaluate the development of broiler chickens treated with thymulin 5cH by conventional zoo technical indices, phytohemaglutinin induced inflammation test and histomorphometric analysis of lymphoid organs (thymus, Fabricius bursa and spleen). Animals were divided in two groups: (a) test: birds with free access to thymulin 5cH diluted into the drink water and (b) control: birds with free access to water only, from the 1st to the 42nd day of life. All experimental procedures were done in blind. The results show that thymulin 5cH treated group had increased productivity index compared to control (391.45 versus 261.93) associated with higher viability in the 7th week (p = 0.013), and a possible shunt to B lymphocyte activity. The data suggest that thymulin 5cH could be a viable method to improve productivity in poultry production due to its immune modulation properties.

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Section: Discussionsupporting

confidence: 92%

Development of broiler chickens after treatment with thymulin 5cH: a zoo technical approach

2012

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“…Since the amplitude of pineal NAT activity and melatonin production is controlled by the rhythmic delivery of noradrenaline, itself driven by the circadian function of the vSCN [Cassone et al, 19901, the vSCN-SCG-pineal complex appears as the most probable locus of interference between bursal signals (or the absence of bursal signals) and pineal rhythms. This hypothesis is strengthened by the fact that the excision of the bursa anlage (4th day of embryonic life) preceded the beginning of pineal sympathetic innervation, which occurs by day 20 of embryonic life are under way, and some reports are compelling [Bastide et al, 1985;Jacobs et al, 1994;Bastide and Boudard, 19951. Finally, using a relevant experimental model, we have provided evidence that a compound found in the bursal microenvironment can functionally mimic in vivo some biological functions of the bursa fabricii.…”

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confidence: 99%

A role for bursa fabricii and bursin in the ontogeny of the pineal biosynthetic activity in the chicken

Youbicier-Simo¹,

Boudard²,

Mekaouche³

et al. 1996

Journal of Pineal Research

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The tripeptide bursin (Lys-His-Gly-NH2) is a B cell differentiation hormone derived from the bursa fabricii. The latter is a cloacal diverticulum and the site of B lymphocyte differentiation and selection in aves; also the bursa fabricii is involved in endocrine functions. Herein we demonstrate that in the chicken, the bursa fabricii and bursin are crucial to the ontogeny of both the pineal response to antigenic challenge and pineal circadian synthetic activity. In early embryonically bursectomized chickens, the plasma melatonin response to immunization by porcine thyroglobulin (Tg) was abolished. Also, the amplitudes of both plasma melatonin and pineal N-acetyltransferase (NAT) circadian rhythms were reduced by 50%, whereas the activity of hydroxyindole-O-methyltransferase (HIOMT) remained unchanged. Conversely, administration of either minute amounts (100 pg, 100 fg) or highly dilute (5 x 10(-27) g) bursin, with the exception of a highest dose (100 micrograms), to bursaless embryos induced recovery of normal antigen-induced melatonin response and normal amplitudes of melatonin and NAT rhythms. These findings establish that early in embryonic life, the bursa fabricii and its derived signal (bursin) are essential for normal development of pineal synthetic activity and underline the efficacy of very dilute bursin as an informative signal.

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“…Her first experiment was mentioned, in which C57/BL6 mice with P815 mastocytoma were treated with different centesimal potencies of thymulin and exhibited a clear immune depressive effect, with decrease in the specific anti-tumor activity of T cells. 15,16 Another series of experiments that were performed by 17,18 were also mentioned, showing that thymulin 9C modulated the T-cell dependent humoral antibody response and respective corticosterone serum levels in mice, with an emphasis on seasonal variations in these effects.…”

Section: High Dilutions Of Thymulin Bursin and Other Hormonesmentioning

confidence: 99%

Immunological models in high dilution research following M Bastide

Bonamin

Bellavite

2015

Homeopathy

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In 1994, Madeleine Bastide described experimental models in immunology that were used during the 1980s to investigate high dilution effects on several biological systems. She classified the available papers in four categories: High dilutions of antigens; High dilutions of thymus, bursa and other hormones; High dilutions of cytokines; Immunopharmacological activity of silica. The studies about high dilutions of antigens were not continued after this period, but gave rise to a long process of a series of in vitro models on antigens and histamine dilutions, that led to the demonstration of the biological modulation effects of these preparations on basophil degranulation. During this process, a multi-centre study was performed, with a high degree of reproducibility among different independent laboratories. The studies about high diluted cytokines, thymulin and other hormones opened a new line of scientific investigation, about the regulatory properties of endogenous substances prepared according to homeopathic methods. The most frequently studied substance, thymulin, when administered to mice at 5cH potency, is able to improve the activity of phagocytes in different experimental situations, such as viral, bacterial and parasitic infections. The immunopharmacological activity of silica was demonstrated, at that time, as an in vivo illustration of the homeopathic 'similia principle'. More recently, studies on silica have assumed another focus: the putative role of silica as active contaminant present in high dilutions. This paper presents a follow-up summary on these items, considering the evolution of discoveries from 1994 to 2014.

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Activity and chronopharmacology of very low doses of physiological immune inducers

Cited by 29 publications

References 2 publications

Development of broiler chickens after treatment with thymulin 5cH: a zoo technical approach

Development of broiler chickens after treatment with thymulin 5cH: a zoo technical approach

A role for bursa fabricii and bursin in the ontogeny of the pineal biosynthetic activity in the chicken

Immunological models in high dilution research following M Bastide

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