Activity and isoenzyme patterns of glycolytic enzymes during perinatal development of rat lung

Rijksen, Gert; Staal, Gerard E.J.; Streefkerk, M.; Vries, A.C.J. de; Batenburg, Joseph J.; Heesbeen, Ellen C.; Golde, L.M.G. Van

doi:10.1016/0304-4165(85)90257-0

Cited by 17 publications

(6 citation statements)

References 19 publications

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“…Glucose 6-phosphate is formed as an intermediate during glycogen breakdown and dihydroxyacetonephosphate is a glycolytic source for surfactant phospholipid synthesis. In a previous study [7] we showed that the specific activity of phosphofructokinase, the only key enzyme between glucose 6-phosphate and dihydroxyacetonephosphate, increased concomitantly with the onset of prenatal surfactant synthesis.…”

Section: Discussionmentioning

confidence: 86%

“…In view of these findings the following remarks can be made: (i) as hybridization is possible between the three subunits, lung phosphofructokinase consists of many different isozymes and we might expect a very complex regulation of phosphofructokinase activity; (ii) the increase in phosphofructokinase specific activity in the period before birth [7] is not associated with a change in subunit composition; (iii) a difference in regulation of phosphofructokinase activity on the basis of subunit composition during lung development is not to be expected.…”

Section: Discussionmentioning

confidence: 99%

“…Bourbon et al [6] provided direct evidence for the formation of saturated phosphatidylcholine from prelabeled endogenous glycogen in fetal rat lung. In a previous report we considered the possible role of glycolysis during the period of glycogen breakdown and onset of surfactant synthesis in rat lung [7]. The specific activity of one of the key enzymes of glycolysis phosphofructokinase, was found to be increased during this period.…”

Section: Introductionmentioning

confidence: 94%

“…As the protein content of the rat lung at day 2 is approx. 44 mg protein per gram wet weight [7], the average level of glucose 1,6-bisphosphate is 46/~mol/kg wet weight.…”

Section: Levels Of Glucose 16-bisphosphate and Fructose 26-bisphospmentioning

confidence: 99%

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Phosphofructokinase in rat lung during perinatal development: characterization of subunit composition and regulation by fructose 2,6-bisphosphate and glucose 1,6-bisphosphate

Heesbeen¹,

Rijksen²,

Batenburg

et al. 1987

Biochimica et Biophysica Acta (BBA) - General Subjects

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

“…As the protein content of the rat lung at day 2 is approx. 44 mg protein per gram wet weight [7], the average level of glucose 1,6-bisphosphate is 46/~mol/kg wet weight.…”

Section: Levels Of Glucose 16-bisphosphate and Fructose 26-bisphospmentioning

confidence: 99%

See 2 more Smart Citations

Phosphofructokinase in rat lung during perinatal development: characterization of subunit composition and regulation by fructose 2,6-bisphosphate and glucose 1,6-bisphosphate

Heesbeen¹,

Rijksen²,

Batenburg

et al. 1987

Biochimica et Biophysica Acta (BBA) - General Subjects

Self Cite

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“…In general, glycogen may constitute a source of energy as well as a source of substrates for the production of all lipid bilayers of the cell. Evidence that in type II cells glycogen may also specifically provide substrates for surfactant phospholipid biosynthesis has been obtained in biochemical studies of the developing rat lung (review by Possmayer 1984;Rijksen et al 1985;Farrell and Bourbon 1986;Bourbon et al 1987). Glycogen particles have been demonstrated in developing and mature MLB of late fetal monkey lungs (Chi 1985).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural characteristics of inclusion bodies of type II cells in late embryonic mouse lung

1990

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As we reported earlier, type II alveolar epithelial cells make their appearance in the early embryonic mouse lung around day 14.2, and show distinctive ultrastructural features. The present study focuses on the ultrastructural characteristics of the inclusion bodies by investigating embryos aged 17-19 days (birth on day 19), using transmission electron microscopy. Late embryonic type II cells appear also as low-columnar or cuboid cells having large, approximately round nuclei and cytoplasm displaying typical features of a differentiated cell. The inclusion bodies show a widespread distribution and are extremely variable in appearance. Schematically we discern five main types, namely cytoplasmic, granular/flocculent, multivesicular, dense, and (multi)lamellar, which occur with intermediate and composite forms. All these inclusion bodies frequently contain glycogen particles, and show a structural relation to profiles of endoplasmic reticulum which are wrapped around them. Other distinctive properties are the osmiophily of multivesicular inclusion bodies, and the presence of vesicles in many dense inclusion bodies. The possible interrelationship, and the differences in various aspects of electron density, suggest that the five main types of inclusion bodies may represent different stages in the formation of mature multilamellar bodies.

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Ultrastructural features of type II alveolar epithelial cells in early embryonic mouse lung

1988

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Immunofluorescence studies of type II alveolar epithelial cells indicate that they first appear in the pseudoglandular period of mouse lung development (around day 14.2). They are the only cell type to line the prospective pulmonary acinus at this time. The ultrastructural characteristics of this cell are defined by investigating embryos aged 13-16 days with transmission and scanning electron microscopy. Early embryonic type II cells appear as low-columnar or cuboid cells having large, approximately round nuclei and distinct ultrastructural features, including a well-developed Golgi apparatus with many associated vesicles, multivesicular bodies, dense bodies, and large apical and basal glycogen fields. These fields represent a distinctive property of the cell. Frequently, they show compartmentalization due to the presence of membrane systems, and association with dense bodies of various sizes.

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Activity and isoenzyme patterns of glycolytic enzymes during perinatal development of rat lung

Cited by 17 publications

References 19 publications

Phosphofructokinase in rat lung during perinatal development: characterization of subunit composition and regulation by fructose 2,6-bisphosphate and glucose 1,6-bisphosphate

Phosphofructokinase in rat lung during perinatal development: characterization of subunit composition and regulation by fructose 2,6-bisphosphate and glucose 1,6-bisphosphate

Ultrastructural characteristics of inclusion bodies of type II cells in late embryonic mouse lung

Ultrastructural features of type II alveolar epithelial cells in early embryonic mouse lung

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