Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry

Chung, Chueh Yao; Liu, Ching-Hsuan; Burnouf, Thierry; Wang, Guey Horng; Chang, Shun Pang; Jassey, Alagie; Tai, Chen Jei; Huang, Chun‐Ying; Richardson, Christopher D.; Yen, Ming Hong; Lin, Chih‐Hsueh; Lin, Liang

doi:10.1016/j.antiviral.2016.03.012

Cited by 59 publications

(33 citation statements)

References 59 publications

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“…SSb2 was the most effective alkaloid, which significantly inhibited the HCV infection . The activity of Phyllanthus urinaria plant extract against the HCV early entry was observed by Chung et al (2016). According to their study, the presence of loliolide, a monoterpene hampered the viral attachment to the host membrane, and thus inhibited its entry.…”

Section: Terpenes and Terpenoids As Antiviral Agentsmentioning

confidence: 99%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

131

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Section: Terpenes and Terpenoids As Antiviral Agentsmentioning

confidence: 99%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

131

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“…SSb2 could inactivate cell-free HCV particles and was suggested to target the glycoprotein E2 in mediating its antiviral effect against HCV infection. Several other natural compounds including the gallic acid (GA) extracted from Limonium sinense [103], the hydrolyzable tannins chebulagic acid (CHLA) and punicalagin (PUG) [104], and the hepatoprotective plant Phyllanthus urinariaderived monolactone loliolide (LOD) [105] and butenolide (4R,6S)-2-dihydromenisdaurilide (DHMD) [106] were also found to efficiently inactivate cell-free HCV viral particles and impede viral attachment. Another natural compound curcumin extracted from turmeric was shown to decrease the fluidity of viral envelope and therefore prevent the binding and fusion [107], possibly by inserting into the membrane in a manner similar to cholesterol [108].…”

Section: Small Molecules Inhibiting Viral Attachmentmentioning

confidence: 99%

Strategies to Preclude Hepatitis C Virus Entry

Burnouf¹,

Lin²

2017

Advances in Treatment of Hepatitis C and B

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Without a preventive vaccine, hepatitis C virus (HCV) remains an important pathogen worldwide with millions of carriers at risk of end-stage liver diseases. Despite the introduction of novel direct-acting antivirals (DAAs), resistance problems, challenges with the difficult-to-treat populations and high costs limit the widespread application of these drugs. Antivirals with alternative mechanism(s) of action, such as by restricting viral entry or cell-to-cell spread, could help expand the scope of antiviral strategies for the management of hepatitis C. Transfusion-associated HCV infection remains another issue in endemic and resource-limited areas around the world. This chapter describes some of the latest developments in antiviral strategies to preclude HCV entry, such as through monoclonal antibodies and small molecules, as well as measures to enhance the safety of therapeutic plasma products in blood transfusion.

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“…Phyllanthus urinaria and its bioactive compound LOD work as potent HCV entry inhibitors [70]. Flavonoids isolated from Cichorium glandulosum Boiss seeds have shown hepatoprotective activity both in vitro and in vivo against carbon tetrachloride-induced hepatotoxic mice [71]. Similarly, turmeric extract and its active compound curcumin were also found protective against chronic CCl4-induced liver damage [72].…”

Section: Plant Based Medicinesmentioning

confidence: 99%

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

Upadhyay¹

2017

J Cell Sci Ther

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Present review article explains various causes of acute liver diseases and their therapeutics. This article describes major reasons of hepatic pathophysiological conditions and diseases including hepatitis, cholestasis, alcoholic and non-alcoholic steatohepatitis, jaundice, liver cirrhosis, carcinogenesis and many others. This article emphasizes use of proliferating hepatocytes, hepatic oval cells, adult human liver mesenchymal stem/progenitor cells, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells in cell transplantation for restoration of liver structure and function. It also justified the therapeutic role of cell secreted growth factors and dietary factors required during natural healing and regeneration liver after surgery or liver transplantation. It sketches out regulatory roles of signaling pathways, expression of cell cycle regulators, growth factors, cytokines, and role of different mitogens in induction of liver stem/progenitor cells (LSPCs) after organ/stem cell transplantation. This article suggests a need for development of new advanced biomaterials, methods, technologies and stem cells for development of targeted therapies to combat and cure liver related diseases and disorders. This article also advice people for avoiding excessive use of alcohol, drugs, fats, salt, high energy diets, and iron as all are responsible of liver cirrhosis, damage and failure.

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Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry

Cited by 59 publications

References 59 publications

Phytochemicals as Antiviral Agents: Recent Updates

Phytochemicals as Antiviral Agents: Recent Updates

Strategies to Preclude Hepatitis C Virus Entry

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

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