Aim: To conduct ABC, VED and ABC-VED matrix analysis of the pharmacy store of the tertiary care, teaching, research and referral institute of the Northern India to identify the categories of drugs needing strict management control. Method: The ABC and VED (vital, essential, desirable) 19%, 19.83% and 9.98% of ADE of the pharmacy. VED analysis showed 12.30%, 61.5% and 26.2% items as V, E, and D category items, respectively, accounting for 19.56%, 71.12% and 9.33% of ADE of the pharmacy. However ABC analysis of pharmacy store for the year 2009-10 revealed 11.08%, 22.16% and 66.75% items as A, B and C category items, respectively, accounting for 70.04%, 19.93% and 10.02% of ADE of the pharmacy. VED analysis showed 12.40%, 60.16% and 27.44% items as V, E, and D category items, respectively, accounting for 25.05%, 66.91% and 8.04% of ADE of the pharmacy. Conclusion: The ABC and VED techniques should be adopted for optimal and rational use of resources and elimination of out-of-stock situations in the hospital pharmacy.