Activity‐Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond

Bruemmer, Kevin J.; Crossley, Steven W. M.; Chang, Christopher J.

doi:10.1002/anie.201909690

Cited by 216 publications

(182 citation statements)

References 363 publications

(648 reference statements)

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“…4d ). Of note, the probe is inert to other ROS, RNS and RSS, such as H 2 O 2 , • OH, O 2 − , ClO − , SO 3 2− , H 2 S, NO 3 − , and ONOO − 50 . Moreover, the probe exhibits neither response to metal ions, nor GSH/Cys.…”

Section: Resultsmentioning

confidence: 99%

Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

Feng

Zhang

et al. 2021

Nat Commun

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Nitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), have yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with increased conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. The probe is capable of detecting and differentiating encephalitis in different severities with high spatiotemporal resolution. This work will inspire more insights into the development of high-performing activatable PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.

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Section: Resultsmentioning

confidence: 99%

Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

Feng

Zhang

et al. 2021

Nat Commun

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“…In the present review, we summarize molecular imaging (MI) agents targeting the B1R and B2R. MI is a research discipline that enables the visualization, characterization, and quantitation of biological processes at the cellular and/or anatomical levels [ 9 , 10 , 11 ]. MI is used to study conditions that underlie normal physiology and pathologies.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

Lau¹,

Rousseau²,

Kwon³

et al. 2020

Pharmaceuticals

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Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention, smooth muscle contraction, and algesia, while B1R is absent in normal tissues and is induced by tissue trauma or inflammation. B2R is activated by kinins, while B1R is activated by kinins that lack the C-terminal arginine residue. Perturbations of the kinin system have been implicated in inflammation, chronic pain, vasculopathy, neuropathy, obesity, diabetes, and cancer. In general, excess activation and signaling of the kinin system lead to a pro-inflammatory state. Depending on the disease context, agonism or antagonism of the bradykinin receptors have been considered as therapeutic options. In this review, we summarize molecular imaging agents targeting these G protein-coupled receptors, including optical and radioactive probes that have been used to interrogate B1R/B2R expression at the cellular and anatomical levels, respectively. Several of these preclinical agents, described herein, have the potential to guide therapeutic interventions for these receptors.

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“…Other strategies that use small‐molecule ligands to modulate the function of proteins, in particular proteolysis targeting chimeras (PROTACs), have been recently reviewed elsewhere and will not be covered here. Fluorogenic sensors based on chemical and enzymatic reactions have also been reviewed recently and only a few examples will be discussed here.…”

Section: Introductionmentioning

confidence: 99%

Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery

2020

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Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.

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Activity‐Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond

Cited by 216 publications

References 363 publications

Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery

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