1995
DOI: 10.1038/376074a0
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Activity-dependent long-term enhancement of transmitter release by presynaptic 3′,5′-cyclic GMP in cultured hippocampal neurons

Abstract: Long-term potentiation (LTP) in hippocampus is a type of synaptic plasticity that is thought to be involved in learning and memory. Several lines of evidence suggest that LTP involves 3',5'-cyclic GMP (cGMP), perhaps as an activity-dependent presynaptic effector of one or more retrograde messengers (refs 2-12, but see ref. 13). However, previous results are also consistent with postsynaptic effects of cGMP. This is difficult to test in hippocampal slices, but more rigorous tests are possible in dissociated cel… Show more

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Cited by 291 publications
(219 citation statements)
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“…It has been shown that hippocampal LTP is accompanied by an enhanced transmitter release (Malgaroli et al, 1995;Zakharenko et al, 2001). Furthermore, there is evidence for an involvement of retrograde messengers (Bliss and Collingridge, 1993;Volgushev et al, 2000) and presynaptic second messengers (Arancio et al, 1995) in the expression of LTP. Thus, the question of the locus of LTP and LTD has not yet been answered.…”
Section: Abstract: Caged Compounds; Expression Site; Ltp; Ltd; Neocomentioning
confidence: 99%
“…It has been shown that hippocampal LTP is accompanied by an enhanced transmitter release (Malgaroli et al, 1995;Zakharenko et al, 2001). Furthermore, there is evidence for an involvement of retrograde messengers (Bliss and Collingridge, 1993;Volgushev et al, 2000) and presynaptic second messengers (Arancio et al, 1995) in the expression of LTP. Thus, the question of the locus of LTP and LTD has not yet been answered.…”
Section: Abstract: Caged Compounds; Expression Site; Ltp; Ltd; Neocomentioning
confidence: 99%
“…Clustering and retention of the receptors at postsynaptic sites appears to be dependent on intracellular anchoring proteins [57]. Some of these interacting PSD-associated proteins (e.g., chapsyn, GKAP[58,59]) redistribute during synaptogenesis following a pattern, which is consistent with a role in glutamatergic synapse formation [44,46,60,61].NMDAR-dependent LTP has been observed in cultured hippocampal neurons using repetitive stimulation of the presynaptic partner of synaptically coupled neurons [62,63,64,65]. It has also been observed following field stimulation [66] or by the transient application of Lglutamate [67].…”
mentioning
confidence: 72%
“…Dual intracellular recording from pairs of dissociated hippocampal or neocortical neurons is a widely accepted method of studying synaptic plasticity (Arancio et al, 1995;Bi and Poo, 1998;Goda and Stevens, 1996;Kaplan et al, 2003). Such experiments are often done with low density cultures.…”
Section: Introductionmentioning
confidence: 99%
“…In dissociated cultured neurons, experiments on synaptic physiology are typically done between one and three weeks in vitro (Arancio et al, 1995;Bekkers et al, 1990;Bekkers and Stevens, 1995;Bi and Poo, 1998;Goda and Stevens, 1996;Gomperts et al, 2000;Kaplan et al, 2003). Earlier than one week, there is little or no synaptic transmission (Gomperts et al, 2000).…”
Section: Introductionmentioning
confidence: 99%