Activity-dependent regulation of calcium and ribosomes in the chick cochlear nucleus

Call, C.L.; Hyson, Richard L.

doi:10.1016/j.neuroscience.2015.12.042

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…In the barrel cortex, induced FMRP upregulation requires the activation of metabotropic glutamate receptor (mGluR), as whisker stimulation dependent expression of FMRP was abolished by pharmacological blockade of type I mGluR (Todd et al, 2003). In the NM, removal of mGluR activation increases intracellular calcium concentration and negatively affects ribosome activity, which may eventually contribute to the death of NM neurons (Call & Hyson, 2016; Carzoli & Hyson, 2011; Zirpel & Rubel, 1996). If mGluR activation and inactivation are also involved in afferent‐regulated FMRP dynamics in NM, this signal pathway may be a potential candidate for studying differential responses in FMRP expression in response to altered afferent activity across cell types.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Wang

Sakano

et al. 2020

J of Comparative Neurology

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Afferent activity dynamically regulates neuronal properties and connectivity in the central nervous system. The Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates cellular and synaptic properties in an activitydependent manner. Whether and how FMRP level and localization are regulated by afferent input remains sparsely examined and how such regulation is associated with neuronal response to changes in sensory input is unknown. We characterized changes in FMRP level and localization in the chicken nucleus magnocellularis (NM), a primary cochlear nucleus, following afferent deprivation by unilateral cochlea removal. We observed rapid (within 2 hr) aggregation of FMRP immunoreactivity into large granular structures in a subset of deafferented NM neurons. Neurons that exhibited persistent FMRP aggregation at 12-24 hr eventually lost cytoplasmic Nissl substance, indicating cell death. A week later, FMRP expression in surviving neurons regained its homeostasis, with a slightly reduced immunostaining intensity and enhanced heterogeneity. Correlation analyses under the homeostatic status (7-14 days) revealed that neurons expressing relatively more FMRP had a higher capability of maintaining cell body size and ribosomal activity, as well as a better ability to detach inactive presynaptic terminals. Additionally, the intensity of an inhibitory postsynaptic protein, gephyrin, was reduced following deafferentation and was positively correlated with FMRP intensity, implicating an involvement of FMRP in synaptic dynamics in response to reduced afferent inputs. Collectively, this study demonstrates that afferent input regulates FMRP expression and localization in ways associated with multiple types of neuronal responses and synaptic rearrangements.

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Section: Discussionmentioning

confidence: 99%

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Wang

Sakano

et al. 2020

J of Comparative Neurology

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“…Further studies have shown that this activity-dependent regulation of protein synthesis relies on activity of mGluRs [124,125], but not involve iGluRs [126]. Specifically, group I and II mGluRs are required to maintain protein synthesis in NM neurons, because blocking either group I or II mGluRs eliminates activity-dependent regulation of ribosomes in vitro [127,128] as well as in vivo [129]. Together, these studies demonstrate the regulatory roles of mGluRs in Ca 2+ signaling and protein synthesis, suggesting potential neuroprotective effects of mGluRs under both normal and abnormal hearing conditions.…”

Section: Mglurs In Avian Auditory Brainstemmentioning

confidence: 99%

Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System

Tang

2018

TAP

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Glutamate, as the major excitatory neurotransmitter used in the vertebrate brain, activates ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs), which mediate fast and slow neuronal actions, respectively. mGluRs play important modulatory roles in many brain areas, forming potential targets for drugs developed to treat brain disorders. Here, we review studies on mGluRs in the mammalian and avian auditory system. Although anatomical expression of mGluRs in the cochlear nucleus has been well characterized, data for other auditory nuclei await more systematic investigations especially at the electron microscopy level. The physiology of mGluRs has been extensively studied using in vitro brain slice preparations, with a focus on the auditory circuitry in the brainstem. These in vitro physiological studies have demonstrated that mGluRs participate in synaptic transmission, regulate ionic homeostasis, induce synaptic plasticity, and maintain the balance between Excitation and Inhibition (E/I) in a variety of auditory structures. However, the modulatory roles of mGluRs in auditory processing remain largely unclear at the system and behavioral levels, and the functions of mGluRs in auditory disorders remain entirely unknown.

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A role for inhibition in deafness-induced plasticity of the avian auditory brainstem

Carroll

Hyson

2016

Neuroscience

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Activity-dependent regulation of calcium and ribosomes in the chick cochlear nucleus

Cited by 4 publications

References 37 publications

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System

A role for inhibition in deafness-induced plasticity of the avian auditory brainstem

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