Activity dependent therapies modulate the spinal changes that motoneurons suffer after a peripheral nerve injury

Arbat-Plana, Ariadna; Torres-Espín, Abel; Navarro, Xavier; Udina, Esther

doi:10.1016/j.expneurol.2014.10.009

Cited by 38 publications

(73 citation statements)

References 63 publications

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“…Axotomized motoneurons suffered massive synaptic stripping of their central dendritic arbor and reduction in PNN around their soma, as previously reported (Arbat‐Plana et al ., ). These alterations were partially reverted in injured animals subjected to a high‐intensity treadmill running exercise for two weeks after the injury, whereas a protocol of lower intensity had milder effects.…”

Section: Resultsmentioning

confidence: 97%

Effects of forced, passive, and voluntary exercise on spinal motoneurons changes after peripheral nerve injury

Arbat-Plana

Navarro

Udina

2017

Eur J of Neuroscience

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After peripheral nerve injury, there are important changes at the spinal level that can lead to disorganization of the central circuitry and thus compromise functional recovery even if axons are able to successfully regenerate and reinnervate their target organs. Physical rehabilitation is a promising strategy to modulate these plastic changes and thus to improve functional recovery after the damage of the nervous system. Forced exercise in a treadmill is able to partially reverse the synaptic stripping and the loss of perineuronal nets that motoneurons suffer after peripheral nerve injury in animal models. The aim of this study was to investigate whether passive exercise, by means of cycling in a motorized bicycle, or voluntary free running in a wheel is able to mimic the effects induced by forced exercise on the changes that axotomized motoneurons suffer after peripheral nerve injury. Partial preservation of synapses and perineuronal nets was observed only in axotomized motoneurons from animals subjected to high-intensity cycling and the ones that freely ran long distances, but not when low-intensity exercise protocols were applied. Therefore, the intensity but not the type of exercise used is the key element to prevent synaptic stripping and loss of perineuronal nets in motoneurons after axotomy.

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Section: Resultsmentioning

confidence: 97%

Effects of forced, passive, and voluntary exercise on spinal motoneurons changes after peripheral nerve injury

Arbat-Plana

Navarro

Udina

2017

Eur J of Neuroscience

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“…Therefore, we can conclude that during injuryinduced compensatory processes PNNs are highly modifiable structures, and the content of PNN growth-regulatory cues can be actively modulated to facilitate or restrict structural plasticity according to specific functional requirements. Moreover, PNN modulation in the LVN may be an activity-dependent process, with PNN maintenance strongly controlled by sensory inputs, as also shown in the spinal cord by Arbat-Plana et al (2015) and Smith et al (2015). The mechanisms which regulate the expression and turnover of PNN components have not been completely elucidated.…”

Section: Perineuronal Net Changes In the Lvn During Vestibular Compenmentioning

confidence: 97%

Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse

et al. 2015

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Perineuronal nets (PNNs) are aggregates of extracellular matrix molecules surrounding several types of neurons in the adult CNS, which contribute to stabilising neuronal connections. Interestingly, a reduction of PNN number and staining intensity has been observed in conditions associated with plasticity in the adult brain. However, it is not known whether spontaneous PNN changes are functional to plasticity and repair after injury. To address this issue, we investigated PNN expression in the vestibular nuclei of the adult mouse during vestibular compensation, namely the resolution of motor deficits resulting from a unilateral peripheral vestibular lesion. After unilateral labyrinthectomy, we found that PNN number and staining intensity were strongly attenuated in the lateral vestibular nucleus on both sides, in parallel with remodelling of excitatory and inhibitory afferents. Moreover, PNNs were completely restored when vestibular deficits of the mice were abated. Interestingly, in mice with genetically reduced PNNs, vestibular compensation was accelerated. Overall, these results strongly suggest that temporal tuning of PNN expression may be crucial for vestibular compensation.

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“…After transection, synaptophysin immunoreactivity was increased in the substantia gelatinosa ipsilateral to the injury and, after crush injury of rat sciatic nerve, solid synaptophysin immunoreactivity was observed in the regenerating sprouts that emerged from the proximal nodes of Ranvier . However, in the central nervous system, a slight reduction in synaptophysin immunoreactivity, in L3–L6 levels of the spinal cord was seen after sciatic nerve transaction . On the other hand, we found that rats with physical activity, especially BCT, had more synaptic plasticity compared with unexercised animals with sciatic nerve crush.…”

Section: Discussionmentioning

confidence: 63%

Balance and coordination training, but not endurance training, enhances synaptophysin and neurotrophin‐3 immunoreactivity in the lumbar spinal cord after sciatic nerve crush

et al. 2015

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Activity dependent therapies modulate the spinal changes that motoneurons suffer after a peripheral nerve injury

Cited by 38 publications

References 63 publications

Effects of forced, passive, and voluntary exercise on spinal motoneurons changes after peripheral nerve injury

Effects of forced, passive, and voluntary exercise on spinal motoneurons changes after peripheral nerve injury

Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse

Balance and coordination training, but not endurance training, enhances synaptophysin and neurotrophin‐3 immunoreactivity in the lumbar spinal cord after sciatic nerve crush

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