Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense

Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts

“…C. DC. showed no cytotoxic activity against MCF-7 cell lines (Portet et al, 2007); ethanol extract of Piper sarmentosum Roxb. inhibited HepG2 cells and nonmalignant Chang's liver cell lines (Ariffin et al, 2009); dichloromethane and methanol extracts from fruits of Piper nigrum L. and Piper chaba Hunter were inactive against C32 and HeLa cell lines (Atjanasuppat et al, 2009); although, E-piplartine isolated from roots of P. chaba showed cytotoxicity against several cell lines (BC-8, PCC4, P388S1, IMR32), significantly increased by curcumin (Jyothi et al, 2009).…”

“…By bioassay-guided purification from hexane extract of P. hostmannianum var. berbicense in vitro activity to P. falciparum (IC50 5.64 µM) and in vivo activity against Plasmodium vinckei petteri was demonstrated by (-)-methyllinderatin (Portet et al, 2007). From 94 species detected by ethnobotany in Peru, eight species of Piper were detected, P. aduncum showed activity against P. falciparum (9.6±1.7 µg/mL), and Piper dennisii Trel.…”

GC-MS, FTIR and 1H ,13C NMR Structural Analysis and Identification of Phenolic Compounds in Olive Mill Wastewater Extracted from Oued Oussefrou Effluent (Beni Mellal-Morocco)

“…The infrared spectra were interpreted according to the literature data [37][38][39][40][41][42][43][44][45][46][47]. The FTIR spectra of our sample and the assignments of their infrared absorption bands are reported respectively in Fig.5 and Table 3.…”

“…The band at 1440 cm −1 due to in plane deformation of -CH 2 (CH 2 -C=C) (δ 1 H 2 ppm; δ 13 C 22-30 ppm), the peak at 1372 cm −1 corresponds to C-H bending of CH 3 groups or to COO − antisymmetric stretching [47,49]. The high band intensity at 1232 cm −1 corresponds to the stretching vibration of C ar -O aromatic and/or in plane deformation of CO 2 H in carboxylic acids or unsaturated ethers [37][38][39][40]. The absorption band at 1114 cm −1 corresponds to the vibrations in ether (C sp3 -O-C ar ), alcohols (C sp3 -OH), C sp3 -OH of the carboxylic acids and C sp3 -O of ester [50] as well the large peak around 1040 cm −1 due to carbohydrates of polysaccharides [43,[51][52].…”

Evaluation of the in vivo anti malarial activity of the methanolic leaf extract of Nepata cateria

“…Indeed, the vast majority of the existing anti-malaria chemotherapeutic agents are based on natural products and this fact anticipates that new anti-malaria may constantly emerge from our tropical plants sources if well harnessed, since biological chemo diversity continue to be an important source of molecular templates in the search for anti-malaria drugs (Portet et al, 2007). Further research to isolate, identify, elucidate and characterize the active ingredients, especially from the alkaloids, flavonoids, terpenoids and quinones from which most anti-malaria drugs have been isolated, are encouraged.…”