Activity of angiotensin-converting enzyme (ACE) in reproductive tissues of the stallion and effects of angiotensin II on sperm motility

Ball, B. A.; Gravance, Curtis G.; Wessel, M. T.; Sabeur, Khalida

doi:10.1016/s0093-691x(02)01127-5

Cited by 36 publications

(25 citation statements)

References 33 publications

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“…It is the C-domain that is also the major domain responsible for the conversion of angiotensin I to angiotensin II in vivo . However, as previously discussed, angiotensin II does not appear to be the critical product of testis ACE (Hagaman et al, 1998;Ball et al, 2003). Also, chicken (Gallus gallus) lacks testis ACE expression so that the physiologic requirement for testis ACE does not appear absolute (Esther et al, 1994).…”

Section: Fertilitymentioning

confidence: 93%

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A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

et al. 2012

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Section: Fertilitymentioning

confidence: 93%

“…In horses, the C-domain sequence is HEIGH (accession number: XM_001495589.3). Despite this, the equine testis isoform of ACE (C-domain of the somatic isozyme) is enzymatically active (Ball et al, 2003). Thus, during hundreds of millions of years of evolution, the zinc-binding and enzymatic activity Fig.…”

Section: B Distribution In Naturementioning

confidence: 99%

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

et al. 2012

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“…In stallions, the activity is greater in sperm membrane than in the seminal plasma [16] . All forms of the ACE respond similarly to variable substances, and are equally vulnerable to the specific inhibitors [46] .…”

Section: Akman öZkanlar öZkanlar Oruç Ulaş Zi̇ypak Lehi̇mci̇oğlu Tmentioning

confidence: 92%

“…Angiotensin converting enzyme (ACE) converts the angiotensin I (A-I) to angiotensin II (A-II) and plays a role in the renin-angiotensin system (RAS) to regulate body fluids and electrolytes for maintaining blood pressure via the inactivation of bradykinin [15][16][17] . The ACE genes are encoded isoforms of both somatic (sACE) and testisspecific (tACE) genes [17,18] .…”

Section: Doxorubicin (Dxr) Obtained From Streptomyces Peucetius In 1mentioning

confidence: 99%

“…All forms of the ACE respond similarly to variable substances, and are equally vulnerable to the specific inhibitors [46] . Captopril, an ACE inhibitor, is an example to reduce the ACE activity in the sperm plasma membrane [16] . However, there has been no effect on the sperm motility in longterm Captopril-treated humans [18] .…”

Section: Akman öZkanlar öZkanlar Oruç Ulaş Zi̇ypak Lehi̇mci̇oğlu Tmentioning

confidence: 99%

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Eritropoietin Hormonu ve ACE İnhibitörü, Erişkin Erkek Sıçanların Sperm Parametrelerini Doxorubicin Toksisitesine Karşı Korur

AKMAN¹,

ORUÇ²,

LEHİMCİOĞLU³

et al. 2015

Kafkas Univ Vet Fak Derg

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Doxorubicin (DXR) is used against the cancer but it has some adverse effects (gonadotoxicity, cardiotoxicity and nephrotoxicity). We aimed to determine the effect of DXR toxicity on reproduction and whether Darbepoetin (DP) and Ramipril (RAM) treatments play a protective role against this toxicity in male rats. Herein, adult male Sprague-Dawley rats (n=34) were divided randomly into five groups, as control (Group I; n=7, no medication) and four treatment groups (II to V). DXR was administered to all treatment groups (DXR, 2.5 mg/kg/w i.v. for 3 weeks) and they were Group II (DXR, n=6), Group III (n=7, DP 10 µg/kg/w i.p. for three weeks), Group IV (n=7, RAM 1 mg/kg/d p.o. for four weeks), and Group V (n=7, DP+RAM). Rats in all groups were sacrificed after four weeks of treatment. Spermatological parameters along with histopathological images and malondialdehyde levels of testicular tissue were evaluated. Weights of body, testicles, cauda epididymis and male accessory glands in DXR-treated groups were significantly different (P<0.05) from the control group. DXR toxicity adversely altered all the sperm parameters. But, DP plus RAM treatment in Group V improved the DXR-depressed motility and viable sperm rate. Sperm concentrations significantly decreased (P<0.05) in DXR-treated groups as compared to control group. In Group III and V, the increase in total abnormal sperm rate caused by the DXR injections was prevented. In conclusion, this study indicated that weekly DXR injections in adult rats depressed all the epididymal sperm parameters. Co-treatment by DP and RAM protected the sperm cells against the toxicity due to the DXR administration while single usages of the DP or RAM provided partial improvements. Keywords: Doxorubicin toxication, Erythropoietin, ACE inhibitor, Rat sperm Eritropoietin Hormonu ve ACE İnhibitörü, Erişkin Erkek Sıçanların Sperm Parametrelerini Doxorubicin Toksisitesine Karşı Korur ÖzetKanser tedavisinde kullanılan Doxorubicin'in (DXR), kardiyotoksik ve nefrotoksik yan etkileri ile birlikte gonadotoksik özelliği de bulunmaktadır. Bu çalışmada, yetişkin erkek Sprague-Dawley sıçanlardaki sperm parametreleri üzerine DXR'nin toksik etkisi ile Darbepoetin (DP) ve Ramipril (RAM) tedavisinin bu toksikasyonu önleyici bir rolünün olup olmadığı araştırıldı. Yetişkin 34 adet erkek Sprague-Dawley sıçanlar rastgele 5 gruba ayrıldı. Kontrol grubunda bulunan sıçanlarda (Grup I; n=7) hiçbir ilaç kullanılmadı. Tüm tedavi gruplarında bulunan sıçanlara DXR uygulaması (DXR, 2.5 mg/kg/hafta i.v. 3 hafta, n=27) yapıldı ve bu gruplar Grup II (DXR, n=6), Grup III (DP 10 µg/kg/hafta i.p. 3 hafta, n=7), Grup IV (RAM 1 mg/kg/gün p.o. 4 hafta, n=7) ve Grup V'ten (DP+RAM, n=7) oluştu. Dört haftalık deneysel çalışma sonrasında tüm sıçanlara ötenazi uygulandı. Spermatolojik parametrelerle birlikte histopatolojik muayene ve testiküler dokulardaki malondialdehit (MDA) düzeyleri incelendi. DXR uygulanan gruplardaki ölçülen vücut, testis, kauda epididimis ve erkek eklenti bezlerinin ağırlıkları ile kontrol grubu parame...

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Elevated testicular temperature modulates expression patterns of sperm proteins in Holstein bulls

Newton

Kastelic

Wong³

et al. 2008

Molecular Reproduction Devel

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The objective of this study was to determine the effects of elevated testicular temperature on the expression patterns of sperm proteins in bulls. Ejaculates were collected from sexually mature Holstein bulls (n = 6) twice weekly for 10 weeks. Testicular temperature was elevated in all bulls by scrotal insulation for 72 consecutive hours during Week 2. Triton X-100 extracts of sperm proteins were prepared and subjected to SDS-PAGE. Sperm proteins in the 110 kDa range decreased from pre-thermal insult to Day 28 (start of thermal insult = Day 0), concurrent with decreases in sperm concentration, motility, and morphology, and subsequently increased, approaching pre-thermal insult values by Day 40. Based on mass spectrometry, this band was comprised of angiotensin converting enzyme (ACE), Hexokinase-1, and the alpha-4 subunit of Na(+)/K(+)ATPase. Changes in the expression patterns of these proteins were confirmed by immunoblotting, including the use of a custom antibody against the alpha-4 subunit of Na(+)/K(+)ATPase (testis-specific isoform). Furthermore, a 25 kDa sperm protein (identified as tissue inhibitor of metalloproteinase-2; TIMP-2), had a low expression level in pre-thermal insult samples, increased to Day 28 of post-thermal insult, and subsequently decreased to the pre-thermal insult level by the end of the experimental period. In conclusion, we identified proteins that may serve as molecular markers of impaired sperm function due to elevated testicular temperature, with important implications for fertility predictions. To our knowledge, this is the first report of the identification of a testis-specific isoform of Na(+)/K(+)ATPase in bovine sperm.

show abstract

Activity of angiotensin-converting enzyme (ACE) in reproductive tissues of the stallion and effects of angiotensin II on sperm motility

Cited by 36 publications

References 33 publications

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

Eritropoietin Hormonu ve ACE İnhibitörü, Erişkin Erkek Sıçanların Sperm Parametrelerini Doxorubicin Toksisitesine Karşı Korur

Elevated testicular temperature modulates expression patterns of sperm proteins in Holstein bulls

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