Activity of Antioxidant Enzymes in the Tumor and Adjacent Noncancerous Tissues of Non-Small-Cell Lung Cancer

Zalewska‐Ziob, Marzena; Adamek, Brygida; Kasperczyk, Janusz; Romuk, Ewa; Hudziec, Edyta; Chwalińska, Ewa; Dobija-Kubica, Katarzyna; Rogoziński, Paweł; Bruliński, Krzysztof

doi:10.1155/2019/2901840

Cited by 57 publications

(43 citation statements)

References 48 publications

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“…3B). SOD and GPx are two important antioxidant enzymes (36). The enzymatic activities of SOD and GPx in the brains of MCAO model mice were found to be decreased (Fig.…”

Section: Sino Treatment Mitigates Mcao-associated Inflammation and Oxidative Stressmentioning

confidence: 95%

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke

Zhou²,

Liu

et al. 2021

Exp Ther Med

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Sinomenine (SINO), which is used clinically to treat rheumatoid arthritis and neuralgia, is derived from the root and stems of Sinomenium acutum. SINO has been reported to exert analgesic, sedative and anti-inflammatory effects, and provides a protective role against shock and organ damage. Studies have suggested that SINO primarily exerts it anti-inflammatory function by inhibiting NF-κB signaling. There is also evidence to indicate that SINO may regulate inflammation Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling. The present study aimed to investigate whether the anti-inflammatory and cerebral protective effects of SINO were induced through Nrf2 both in vitro and in vivo. The results revealed that SINO significantly upregulated Nrf2 protein expression levels, increased Nrf2 nuclear translocation and the upregulated the protein expression levels of downstream factors. The treatment of a middle cerebral artery occlusion model mice with SINO effectively reduced cerebral damage and inflammation, and restored the balance in cerebral oxidative stress. In addition, SINO treatment also promoted Nrf2-dependent microglia M1/M2 polarization and inhibited the phosphorylation of IκBα as well as NF-κB nuclear translocation. This revealed an important upstream event that contributed to its anti-inflammatory and cerebral tissue protective effects. In conclusion, the findings of the present study identified a novel pathway through which SINO may exert its anti-inflammatory and cerebral protective functions, and provided a molecular basis for the potential applications of SINO in the treatment of cerebral inflammatory disorders.

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“…3B). SOD and GPx are two important antioxidant enzymes (36). The enzymatic activities of SOD and GPx in the brains of MCAO model mice were found to be decreased (Fig.…”

Section: Sino Treatment Mitigates Mcao-associated Inflammation and Oxidative Stressmentioning

confidence: 95%

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke

Zhou²,

Liu

et al. 2021

Exp Ther Med

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“…Many studies confirmed our findings regarding the lower levels of SOD in lung cancer patients' pre-treatment with cisplatin. 14,4 Moreover, cisplatintreated patients showed no significant differences comparing with control. Little information is known about the correlation between cisplatin and SOD activity.…”

Section: Antioxidant Activity Of Cat Gpx and Sodmentioning

confidence: 95%

“…3 Malignant cells have been the revelation to have the abnormal standard of antioxidant enzymes and efficacy when contrasted with normal cells. 4 However, antioxidant enzyme performance also differs between different tumors. 5 Antioxidant enzymes used to be found in different isoforms, intracellularly and extracellularly, and their action inspires an integrated antioxidant defense system.…”

Section: Introductionmentioning

confidence: 99%

“…11 Part of cisplatin toxicity is the increased ROS generation, which results in alteration of mitochondrial membrane potential (MMP) and disturbs the electron transport chain related to mitochondrial respiration and finally triggering cell apoptosis. 4 Moreover, patients using cisplatin exhibited significant decreases in concentrations for the antioxidant enzymes. Higher levels of ROS may during cisplatin overwhelmed the antioxidant defense systems, affecting the cytotoxic activity of cisplatin and slowing the rate of tumor cells proliferation.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Enzymes Level Detection in Cisplatin Treated Iraqi Lung Cancer Patients and In vitro Estimating the Cytotoxic and Reactive Oxygen Species Generation in A549 Cell Line

Al-Saffar¹,

Hassan²,

Al-Shanon³

2020

ijpqa

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Cisplatin is one of the most important and effective antitumor drug used as treatment against different types of tumors. Cisplatin directly affects DNA integrity as well as the generation of reactive oxygen species (ROS) and cell death induction. Changes in the activities of antioxidant enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were investigated in healthy controls and lung tumor patients before and after cisplatin treatment. Untreated patients showed a significant reduction in CAT, GPx, and SOD levels, while cisplatin-treated patients retained the normal levels of antioxidant enzymes compared with healthy controls. Cisplatin exhibited cytotoxic activity against A549 lung tumor cells in a dose-dependent manner with an IC50 of 10.33 μg mL-1. Cisplatin was found to induce the generation of ROS in cisplatin-treated A549 cells compared with a negative control. Such an increase in ROS production was significantly correlated with increasing cisplatin concentration.

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“…The activity of antioxidant system is particularly important in lung carcinomas as lung tissue is highly susceptible to oxidative stress-induced damage [ 11 ]. One recent study has demonstrated that the activities of different SOD isotypes and catalase are low in lung cancer cells than adjacent normal cells; however, the activities of GPX, glutathione reductase, and glutathione S-transferase are higher in lung cancer cells [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer

et al. 2020

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EGFR mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of EGFR mutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot EGFR mutations. The study findings revealed that a statistically significant association exists between EGFR L858R mutation and AG + GG genotypes of SOD rs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of SOD rs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients.

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Activity of Antioxidant Enzymes in the Tumor and Adjacent Noncancerous Tissues of Non-Small-Cell Lung Cancer

Cited by 57 publications

References 48 publications

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke

Antioxidant Enzymes Level Detection in Cisplatin Treated Iraqi Lung Cancer Patients and In vitro Estimating the Cytotoxic and Reactive Oxygen Species Generation in A549 Cell Line

Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer

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