2015
DOI: 10.2147/ijn.s84108
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Activity of daptomycin- and vancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms

Abstract: The aim of the present study was to develop novel daptomycin-loaded poly-epsilon-caprolactone (PCL) microparticles with enhanced antibiofilm activity against mature biofilms of clinically relevant bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and polysaccharide intercellular adhesin-positive Staphylococcus epidermidis . Daptomycin was encapsulated into PCL microparticles by a double emulsion-solvent evaporation method. For comparison purposes, formul… Show more

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Cited by 14 publications
(11 citation statements)
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“…For example, it was shown that poly-N-acetylglucosamine surface polysaccharide (PNAG or PIA) and extracellular DNA (ecDNA) have different structural roles in S. aureus and S. epidermidis leading to different effects of degrading enzymes 37 . Similar effects to the present study were seen in a previous study using also both methods to analyze the effect of antibiotic-loaded microparticles on S. aureus and S. epidermidis biofilms 32 . Both methods showed that S. aureus (MRSA) biofilm was inhibited by a lower Daptomycin concentration than S. epidermidis biofilm.…”
Section: Discussionsupporting
confidence: 91%
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“…For example, it was shown that poly-N-acetylglucosamine surface polysaccharide (PNAG or PIA) and extracellular DNA (ecDNA) have different structural roles in S. aureus and S. epidermidis leading to different effects of degrading enzymes 37 . Similar effects to the present study were seen in a previous study using also both methods to analyze the effect of antibiotic-loaded microparticles on S. aureus and S. epidermidis biofilms 32 . Both methods showed that S. aureus (MRSA) biofilm was inhibited by a lower Daptomycin concentration than S. epidermidis biofilm.…”
Section: Discussionsupporting
confidence: 91%
“…A further severe problem of implant associated infections is the formation of a biofilm that protects the bacteria 30 , 31 . Penetration of antimicrobial active substances is affected by the biofilm and the altered susceptibility of the bacteria in the biofilm to antibiotics requires much higher dosages of substances to kill the bacteria 32 34 . Two independent approaches were used to analyze the effect of the AMP2 on biofilm.…”
Section: Discussionmentioning
confidence: 99%
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“…The validity of FISH in establishing the improved efficacy of antibiotic-loaded microparticles in staphylococcal biofilms has recently been shown [23]. The present study demonstrates, for the first time, the use of FISH for visualization, quantification, and localization of the rRNA containing cells within a catheter-related biofilm following antibiotic treatment.…”
Section: Discussionsupporting
confidence: 52%
“…Rifampin, a RNA polymerase inhibitor, has also been shown to have some effectiveness against biofilms, although it likely does not provide complete clearance and is often utilized in combination therapies 42 - 46 . Daptomycin and moxifloxacin have also shown efficacy against biofilms formed by Gram positive organisms 45 , 47 , 48 . For Gram negative populations, tobramycin has shown some evidence of efficacy against formed biofilms, although this is likely bolstered by combination therapies with targeted anti-biofilm compounds 49 , 50 .…”
Section: Pharmacological Methods Of Controlling Established Infectionmentioning
confidence: 99%