Activity of gemini quaternary ammonium salts against microorganisms

Obłąk, Ewa; Piecuch, Agata; Rewak‐Soroczyńska, Justyna; Paluch, Emil

doi:10.1007/s00253-018-9523-2

Cited by 73 publications

(51 citation statements)

References 57 publications

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“…A possible mechanism of gemini surfactant activity against biofilm assumes the occurrence of electrostatic interactions that disrupt its functioning, and as a consequence, biofilm cell lysis [47]. In the case of biofilm formed by Gram-positive bacteria, gemini QASs also show biofilm-eliminating activity, which has been confirmed e.g., for alanine gemini surfactants that manifested antibiofilm activity against Staphylococcus epidermidis [40]. However, the research efforts have not been directed only at finding a biocide that would permanently destroy the biofilm, it is also considered essential to prevent microbial adhesion.…”

Section: Activity Of Gemini Quaternary Ammonium Salts Against Bacterimentioning

confidence: 86%

“…have been widely studied [39]. In addition, auxotrophic yeast mutants and mutants with respiratory defects of nuclear (pet) and mitochondrial (rho -, rho 0 ) genes have been found to be sensitive to QASs [40].…”

Section: Antifungal Activity Of Quaternary Ammonium Saltsmentioning

confidence: 99%

“…For this reason, numerous studies have been devoted to the creation of surfaces modified with QASs and their gemini derivatives. It is expected that the surfaces prepared in this way will help to control the phenomenon of adhesion of microorganisms [40].…”

Section: Activity Of Gemini Quaternary Ammonium Salts Against Bacterimentioning

confidence: 99%

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Biological Activity of Quaternary Ammonium Salts and Their Derivatives

2020

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Besides their positive role, microorganisms are related to a number of undesirable effects, including many diseases, biodeterioration and food spoilage, so when their presence is undesired, they must be controlled. Numerous biocides limiting the development of microorganisms have been proposed, however, in this paper the biocidal and inhibitory activity of quaternary ammonium salts (QASs) and their zwitterionic derivatives is addressed. This paper presents the current state of knowledge about the biocidal activity of QAS and their derivatives. Moreover, the known mechanisms of antimicrobial activity and the problem of emerging resistance to QAS are discussed. The latest trends in the study of surfactants and their potential use are also presented.

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Section: Activity Of Gemini Quaternary Ammonium Salts Against Bacterimentioning

confidence: 86%

Section: Antifungal Activity Of Quaternary Ammonium Saltsmentioning

confidence: 99%

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Biological Activity of Quaternary Ammonium Salts and Their Derivatives

2020

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“…11 Another approach to avoid microbial resistance was an application of gemini QASs (double head -double tail type). 12,13 An effect of organic counterions on antibacterial activity was discussed. 14 Conjugates of QASs with steroids were prepared and shown to exhibit a broad spectrum of antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of New Quaternary Ammonium Salts with a Terpene Function and Evaluation of their Fungicidal and Herbicidal Activities

Żelechowski¹,

Gucma²,

Golebiewski³

et al. 2020

ACSi

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A series of new quaternary ammonium salts (QASs) containing a terpenoid moiety derived from perillyl alcohol, citronellol, and geraniol was synthesized. Structures of all novel compounds were confirmed by spectral methods and elemental analyses. Fungicidal activity of the obtained compounds against six plant pathogens, against four fungi destroying wood and technical materials as well as herbicidal activity against ten species of temperate climate weeds has been examined. Several salts showed a higher antifungal and herbicidal activity than activity of the reference compounds.

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“…Cationic surfactants in particular are well known for their antimicrobial activity and are currently employed as disinfectants, antiseptics and preservative agents [2,3]. Several classes of cationic surfactants have been explored and characterised in terms of surface activity and antimicrobial properties [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%