Activity of<i>α</i><sub>1</sub>-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

Woźniak, Bartosz; Woźniak, Alina; Konca, Jacek; Górecki, Dariusz C.; Mila-Kierzenkowska, Celestyna; Szpinda, Michał; Sutkowy, Paweł; Wesołowski, Roland

doi:10.1155/2015/176582

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…Poor lifestyle preferences can contribute to the risk of COPD infection, and smoking is a common risk factor. Nicotine and other components in cigarettes can damage lung tissue, which may lead to pulmonary fibrosis, thereby affecting lung function, and significantly increasing the prevalence of COPD [ 19 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Zhou

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of autoimmune cell therapy on immune cells in patients with chronic obstructive pulmonary disease (COPD) and to provide a reference for clinical treatment of COPD. Methods. Sixty patients with stable COPD were randomly divided into control group and treatment group ( n = 30 ). The control group was given conventional treatment, and the treatment group was given one autoimmune cell therapy on the basis of conventional treatment. The serum levels of CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the peripheral blood were detected by flow cytometry. Possible adverse reactions were detected at any time during treatment. Results. There were no significant differences in the contents of CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the serum of the control group ( P > 0.05 ). Compared with before treatment, the contents of CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the serum of the treatment group were significantly increased ( P < 0.05 ). The ratio of CD 4 + / CD 8 + T cells in both control and treatment groups did not change significantly during treatment ( P > 0.05 ). There were no significant differences in serum CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the treatment group at 30 days and 90 days after treatment ( P > 0.05 ), but they were significantly higher than those in the control group ( P < 0.05 ). Conclusion. Autoimmune cell therapy can significantly increase the level of immune cells in the body and can be maintained for a long period of time, which has certain clinical benefits for recurrent respiratory tract infections and acute exacerbation in patients with COPD.

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Section: Discussionmentioning

confidence: 99%

Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Zhou

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Lysosomal enzymes, in small amounts, constantly leak from lysosomes into the extracellular space and then into the blood. This increased release may, in be selective and may indicate tissue remodeling and/or pathological processes [34]. The present study demonstrated a positive correlation between serum activities of CTS D and ASA in cataract patients (r = 0.43, p = 0.039; Figure 3A) and between serum activities of AcP and ASA in healthy controls (r = 0.35, p = 0.046; Figure 3B), which may suggest the nonselective permeation of enzymes from lysosomes.…”

Section: Discussionmentioning

confidence: 99%

Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study

Sutkowy,

Lesiewska,

Woźniak

et al. 2023

Biomedicines

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Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms of the disease are most arguably related to a redox imbalance and inflammation; therefore, the aim of the study was to evaluate the processes associated with inflammation in cataract patients. Twenty-four patients aged 22–60 years (62.5% females) participated in the study, with 33 controls aged 28–60 years (66.7% females). Venous blood serum of the subjects was examined for alpha 1-antitrypsin, as well as selected lysosomal enzymes and adipokines. The activities of lysosomal enzymes, as well as the activity of alpha 1-antitrypsin and the concentrations of c-reactive protein and leptin, were similar in the patients versus the controls. The concentrations of interleukin 6 and resistin were lower, in turn, whereas omentin-1 and adiponectin were higher. Moreover, the study revealed the existence of many linear relationships between the parameters, including multiple linear regression, especially gender-wise. No systemic inflammation was probably noted in the cataract patients tested; nevertheless, the deregulation of adiponectin, omentin-1 and resistin secretion was observed.

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“…This could mean that short-term CWI used as a postexercise regeneration method did not damage the lysosomal membranes and lysosomal enzymes did not enter the bloodstream. It has been proven that lysosomal enzymes are involved in the formation of post-exercise damage to muscle cells [ 72 , 73 ]. Exercise causes greater oxygen consumption by the mitochondria, leading to increased formation of ROS, which results in peroxidation of the muscle cell membrane.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Ambient Temperature Changes on the Indicators of Inflammation and Oxidative Damage in Blood after Submaximal Exercise

et al. 2022

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Physical activity has a positive effect on human health and well-being, but intense exercise can cause adverse changes in the organism, leading to the development of oxidative stress and inflammation. The aim of the study was to determine the effect of short-term cold water immersion (CWI) and a sauna bath as methods of postexercise regeneration on the indicators of inflammation and oxidative damage in the blood of healthy recreational athletes. Forty-five male volunteers divided into two groups: ‘winter swimmers’ who regularly use winter baths (n = 22, average age 43.2 ± 5.9 years) and ‘novices’ who had not used winter baths regularly before (n = 23, mean age 25 ± 4.8 years) participated in the study. The research was divided into two experiments, differing in the method of postexercise regeneration used, CWI (Experiment I) and a sauna bath (Experiment II). During Experiment I, the volunteers were subjected to a 30-min aerobic exercise, combined with a 20-min rest at room temperature (RT-REST) or a 20-min rest at room temperature with an initial 3-min 8 °C water bath (CWI-REST). During the Experiment II, the volunteers were subjected to the same aerobic exercise, followed by a RT-REST or a sauna bath (SAUNA-REST). The blood samples were taken before physical exercise (control), immediately after exercise and 20 min after completion of regeneration. The concentrations of selected indicators of inflammation, including interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 8 (IL-8), interleukin 10 (IL-10), transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNF-α), as well as the activity of indicators of oxidative damage: α1-antitrypsin (AAT) and lysosomal enzymes, including arylsulfatase A (ASA), acid phosphatase (AcP) and cathepsin D (CTS D), were determined. CWI seems to be a more effective post-exercise regeneration method to reduce the inflammatory response compared to a sauna bath. A single sauna bath is associated with the risk of proteolytic tissue damage, but disturbances of cellular homeostasis are less pronounced in people who regularly use cold water baths than in those who are not adapted to thermal stress.

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Activity ofα₁-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

Cited by 4 publications

References 21 publications

Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study

The Influence of Ambient Temperature Changes on the Indicators of Inflammation and Oxidative Damage in Blood after Submaximal Exercise

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Activity ofα1-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation

Cited by 4 publications

References 21 publications

Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study

The Influence of Ambient Temperature Changes on the Indicators of Inflammation and Oxidative Damage in Blood after Submaximal Exercise

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Activity ofα₁-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation