Activity of Local Anesthetic Agents in Goldfish

Effect of edetate disodium on goldfish membrane

“…Nightingale et al (6) used goldfish to assess structure-toxicity relationships of some substituted phenothiazines. Feldman et al (7) used goldfish to study various local anesthetic agents and found an apparent relationship between the minimum effective concentration of drug to produce a response in goldfish and the minimum blocking concentration of these agents in isolated nerve or muscle fibers (8).…”

Effect of Lidocaine and Derivatives on Time of Death and Overturn in Goldfish

“…Goldfish also were used to study the effects of alkyl chain length on biological activity for n-alkyl esters of p-aminobenzoic acid (5). The activity of local anesthetic agents was studied using goldfish, and a possible relationship between the minimum effective concentration (MEC) of drug in the bathing solution and the minimum blocking concentration of the same anesthetic agent on isolated nerve and muscle fibers was observed (6).…”