Activity of Medicinal Plants, Used by Native Populations from Sonora, Mexico, Against Enteropathogenic Bacteria

Salazar, Sergio Francisco Moreno; Verdugo, Aracely Enríquez; López, Carolina Cuamea; Martínez, Enrique Bolado; Candelas, Teresa; Robles‐Zepeda, Ramón Enrique

doi:10.1080/13880200802215800

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…This plant, commonly known by the name of cosahui, is widely used by ethnic groups in northwestern Mexico, for the treatment of various gastrointestinal diseases such as diarrhea and stomach and intestinal cancer [35]. Antioxidants derived from plant extracts have been shown to have multiple biological activities including vasodilatatory, anti-inflammatory, antiviral, antiproliferative, and antimicrobial effects [16,36,37].…”

Section: Resultsmentioning

confidence: 99%

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

Manuel

Velázquez-Contreras

Garibay‐Escobar

et al. 2013

BMC Complement Altern Med

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BackgroundThe aim of this study, is to investigate the in vitro antioxidant activity, the total phenols content, the flavonoids content and the antiproliferative activity of methanolic extracts of the plants: Krameria erecta, Struthanthus palmeri, Phoradendron californicum, Senna covesii and Stegnosperma halimifolium, used by different ethnic groups from northwestern Mexico in the treatment and cure of various diseases.MethodsThe in vitro antioxidant activity was measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing/Antioxidant Power assay (FRAP), the total phenols content was measured by Folin–Ciocalteau assay, the flavonoids content by the AlCl3 colorimetric method and the antiproliferative activity (line cells HeLa, RAW 264.7, M12Ak.C3.F6 and L929) using MTT method.ResultsThe K. erecta extract showed the higher radical scavenging activity (67.88%), antioxidant activity by FRAP (1.41 mg Trolox Eq), the highest total phenols content (598.51 mg Galic Acid Eq/g extract), the highest flavonoids content (3.80 mg Quercetin Eq/g extract) and the greatest antiproliferative activity in a dose dependent manner against most Cell line evaluated. A positive correlation was found between the antioxidant activity and the flavonoids content.ConclusionsThis study is the first report on the antioxidant and antiproliferative activities of the five species evaluated. The results demostrate that there is a positive correlation between antioxidant activity and the flavonoids content, indicating that these type of polyphenols could be the major contributors to the observed antioxidant activity in the evaluated plant extracts. Of the extracts evaluated, that of Krameria erecta showed the greatest antioxidant and antiproliferative activities, a discovery that makes this species a promising candidate for future research.

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Section: Resultsmentioning

confidence: 99%

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

Manuel

Velázquez-Contreras

Garibay‐Escobar

et al. 2013

BMC Complement Altern Med

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“…[20]. Leaves of Atriplex canescens are used to cure infections of gastrointestinal in Mexico and its methanolic extract show anti-bacterial activity against E.coli and Salmonella typhimurium [21]. In Pakistan, the leaves of Atriplex crossifolia are used in the treatment of yellow jaundice and throat infection [22].…”

Section: Introductionmentioning

confidence: 99%

Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss

Zohra

Ovais

Khalil

et al. 2019

BMC Complement Altern Med

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BackgroundPlants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of various ailments. The current study has been aimed to validate the therapeutic potential of ethnomedicinally significant plant Atriplex lasiantha Boiss.MethodsThe polarity based extraction process was carried out using fourteen solvents to figure out best extraction solvent and bioactive fractions. Total phenolic-flavonoids contents were quantified colorimetrically and polyphenolics were measured using HPLC-DAD analysis. Moreover, the test samples were tested against several diseases targets following various assays including free radicals scavenging, antibacterial, antifungal, cytotoxic and antileishmanial assay.ResultsAmong the solvent fractions, maximum yield was obtained with methanol-water extract i.e., 11 ± 0.49%. Maximum quantity of gallic acid equivalent phenolic content and quercetin equivalent flavonoid content were quantified in methanol-ethyl acetate extract of A. lasiantha. Significant quantity of rutin i.e., 0.3 μg/mg was quantified by HPLC analysis. The methanol-ethyl acetate extract of A. lasiantha exhibited maximum total antioxidant and total reducing power with 64.8 ± 1.16 AAE/mg extract respectively, while showing 59.8 ± 1.07% free radical scavenging potential. A significant antibacterial potential was exhibited by acetone-distilled water extract of A. lasiantha with 11 ± 0.65 mm zone of inhibition against B. subtilis. Considerable antifungal activity was exhibited by ethyl acetate-n-hexane extract of aerial part of A. lasiantha with 14 ± 1.94 mm zone of inhibition against A. fumigatus. Highest percentage of α-amylase inhibition (41.8 ± 1.09%) was observed in ethyl acetate-n-hexane extract. Methanol-acetone extract of A. lasiantha demonstrated significant inhibition of hyphae formation with 11 ± 0.49 mm bald zone of inhibition. Significant in-vitro cytotoxicity against Hep G2 cell line has been exhibited by methanol-chloroforms extract of A. lasiantha.ConclusionThe current study reveals the prospective potential of Atriplex lasiantha Boiss. for the discovery of biologically active compounds through bioassay guided isolation against various diseases.

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“…Hymenoclea monogyra seems to be the least documented; however, different species of the genus have shown antimicrobial properties due to the presence of flavonoids and sesquiterpene lactones. H. monogyra has been reported against enteropathogenic bacteria in BCS and in other regions of northwest Mexico (25). A diversity of active compounds can be extracted from medicinal plants using ethanol-water methods, which makes it an interesting model for the semi-pilot scale extractions, providing confidence for the optimization processes in the formulation of botanical fungicides.…”

Section: Effectiveness Of Dose Response (Ed 50 )mentioning

confidence: 99%

Anti-infective properties of medicinal plants from the Baja California peninsula, Mexico for the treatment of Fusarium oxysporum f. sp. basilici in organic sweet basil (Ocimum basilicum)

et al. 2021

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Certified-organic farming systems in Baja California Peninsula and Northwest Mexico are nationally and globally recognized, especially due to the production of vegetables and aromatic herbs under protected agriculture systems. Based on the background of some species of the flora of Baja California Sur (BCS) to inhibit a diversity of microorganisms, the effect of 22 medicinal plants of the region was explored to know the in vitro activity against the fungus Fusarium oxysporum f. sp. basilici isolated from basil (Ocimum basilicum L.). The plants processed as crude ethanolic and aqueous extracts were analyzed in duplicate (three replicates) evaluating the inhibition of mycelial growth and spore germination. In mycelial inhibition test, all plants extracts (1000 mg L-1) showed an effectiveness of 11 to 40% to inhibit F. oxysporum. The most effective plant extracts according to 50% effective inhibition dose (ED50), were Larrea tridentata, Hymenoclea monogyra and Lippia palmeri with an ED50 of 220, 303 and 3000 mg L-1, respectively. Tukey’s PostHoc tests indicated that H. monogyra and L. tridentata are ten times (ED50 <300 mg L-1) more effective than L. palmeri (ED50 3000 mg L-1). In addition, the dose-response trend analyzes according to the logarithmic-logistic model (drc packages), showed the maximum slope values between 100 and 1000 mg L-1. In the spore germination inhibition tests, most ethanolic extracts (5000 mg L-1) showed an effectiveness between 21 and 80%. The results of this study demonstrated that the inhibitory potential of these plants used in BCS traditional medicine are a viable alternative for the control of F. oxysporum f. sp. basilici in organic basil production systems. Highlights 22 medicinal native plants from the Baja California peninsula can effectively inhibit (in vitro) oxysporum f. sp. basilica. The most effective species were Larrea tridentata, Hymenoclea monogyra and Lippia palmeri with a mycelial growth inhibition (ED50) of 220, 300 and 3000 mg L-1, respectively. In vitro effectiveness of Fusarium-growth inhibition of medicinal plants of BCS were in ED50 ranges from 220 to 3000 mg L-1. Creosote bush (L. tridentata) extract at a dose of 5000 mg L-1 can inhibit the fungal sporulation by up 80%. The ethanol-aqueous extract of the medicinal plants of BCS have the potential to be used for long-term control of the fusariosis disease in basil.

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Activity of Medicinal Plants, Used by Native Populations from Sonora, Mexico, Against Enteropathogenic Bacteria

Cited by 8 publications

References 34 publications

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico

Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss

Anti-infective properties of medicinal plants from the Baja California peninsula, Mexico for the treatment of Fusarium oxysporum f. sp. basilici in organic sweet basil (Ocimum basilicum)

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