Activity of Pericarp Extract of Mangosteen Against Oral Streptococci

Abstract

The increasing prevalence of dental caries is still as a major world health problem. Caries is the direct result of acid production by cariogenic oral pathogens, especially Streptococcus mutans. New and better antimicrobial agents active against cariogenic bacteria with minimal side effects on the oral tissues are much needed, especially natural agents derived directly from plants. Phytochemical studies have shown that the extracts from various parts of mangosteen or Garciniamangostana Linn tree contain varieties of secondary metabolites such as prenylated and oxygenated xanthones, many of which have been found in vitro to have antimicrobial properties against oral pathogens. Several studies which examined the eficacy of herbal for human health have shown that xanthones from mangosteen have remarkable biological activities such as antioxidant, antimicrobial, anticancer etc, and had no cytotoxic effects on human gingival fibroblasts. Their results showed that among these xanthone derivatives obtain from pericarp extract of mangosteen, α-mangostin has the most potent antimicrobial activity against cariogenic Streptococcus mutans. It can be concluded that the strong antimicrobial activity of the pericarp extract of mangosteen is a good drug of choice that might be helpful in preventing the dental caries.

Sterilisasi Alat Kedokteran Gigi Dengan Sterilisator (Dry Heat) Dan Teknik Boiling

“…Metode sterilisasi termasuk tindakan pemanasan kering atau lembab, beragam gas atau cairan bahan kimia, filtrasi, dan radiasi ionasi. Pemilihan sterilisasi bergantung pada bahan material alat yang akan disterilkan, serta organisme yang terlibat (Mustaqimah, 2014).…”