ACTN3 R/X gene polymorphism across ethnicity: a brief review of performance gene

Yusof, Hazwani Ahmad; Nasaruddin, Wan Nor Syahirah; Muhamed, Ahmad Munir Che

doi:10.1007/s11332-019-00584-8

Cited by 2 publications

(3 citation statements)

References 58 publications

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“…This underrepresentation below the reference latitude populations opens a gap for further discussion within the field. This is important especially since the allelic frequencies from our study (0.68 and 0.32 for the R and X alleles, respectively) are comparable to other European (0.58 and 0.42, respectively) [47] and Balkan populations (from 0.59 and 0.41 in Serbia, 0.66 and 0.34 in Albania, to 0.79 and 0.21 in Montenegro) [46]. A factor that seems to be very specific for Kosovo and could be an important factor for genetic studies, is the fact that compared to neighboring countries-such as Albania, Macedonia, and Serbia-Kosovo has had among the lowest number of immigrants in South East Europe.…”

Section: Discussionsupporting

confidence: 75%

ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults

Boshnjaku

Krasniqi

Tschan

et al. 2021

IJERPH

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Maintaining muscle mass and function is important throughout the lifestyle. While environmental factors such as physical activity and healthy nutrition are well investigated, the contribution of genetic factors is still controversial. Therefore, we aimed to investigate the impact of a common ACTN3 polymorphism (rs1815739) on body composition, handgrip strength, knee extensor peak torque, and physical performance (gait speed, 30-s arm curl, 30-s chair stand) in Kosovan adults. In total, 308 participants (160 females and 148 males, age range from 40 to 91 years) took part in this cross-sectional study. Genomic DNA was extracted from saliva and assessed for ACTN3 genotype distribution (41.5% of RR, 53.9% of RX and 4.6% of XX). Genotype allocation did not account for differences in any of the variables. Interestingly, female XX carriers were taller (p = 0.025) and had a higher isokinetic knee extension peak torque (p = 0.024) than the RX+RR group. In males, XX carriers were also taller (p = 0.049) and had a lower BMI (p = 0.026), but did not differ in any of the strength and performance parameters. These results indicate that the ACTN3 R577X polymorphism might exert a sex-specific impact on knee extensor peak torque and BMI.

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Section: Discussionsupporting

confidence: 75%

ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults

Boshnjaku

Krasniqi

Tschan

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…The study of the influence of genes related to physical activity and nutrition has been carried out for approximately 22 years (Ahmad Y. 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Among the genes that have been related to physical and competitive activity are ACTN3 (Ahmetov I. 2014, Ahmad Y. 2020, Ahmetov I.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the ACTN3, ACE, AGT, BDKRB2 and IL6 genes and the intake of creatine HCl, whey protein and glutamine, with changes in strength and fat percentage, before an undulating strength program in lower limbs in athletes from Valle del Cauca. Colombia

Estrada

Paz

Sanclemente

2023

Preprint

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Changes in power, strength and muscle mass gain were measured with a group of university athletes (n=11), separating them into two groups, one with supplementation and the other without supplementation, to determine if the intake of sports supplements had an influence or not on individuals with similar genotypic profiles, or the results of the tests only depended on the predisposition to strength and muscle gain of the ACE, ACTN3, AGT, IL6 and BDKRB2 genes. Genotyping was performed based on PCR, RFLP and polyacrylamide electrophoresis tests. The supplemented group ingested whey protein, creatine HCl, and glutamine. All individuals underwent undulating strength training for four months and jump power tests (SJ, CMJ, and ABA), 1RM, and bioimpedance were performed at three different times. Changes were obtained in all the athletes, but the group that obtained the greatest gains in all the tests, except the CMJ jump, was the supplemented group and also had a genotypic profile that registered the lowest TGS. In conclusion, we observed significant improvements in individuals with lower TGS and taking sports supplements, surpassing the group that did not take supplements, but had a greater genetic predisposition in strength activities.

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ACTN3 R/X gene polymorphism across ethnicity: a brief review of performance gene

Cited by 2 publications

References 58 publications

ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults

ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults

Relationship between the ACTN3, ACE, AGT, BDKRB2 and IL6 genes and the intake of creatine HCl, whey protein and glutamine, with changes in strength and fat percentage, before an undulating strength program in lower limbs in athletes from Valle del Cauca. Colombia

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