Actualización de la enfermedad de Carrión.

Abstract

La Bartonelosis (también llamada Enfermedad de Carrión o Verruga Peruana) es una enfermedad clásica de la medicina peruana. En las últimas dos décadas se han producido nuevos conocimientos e investigacio- nes, que han roto muchos paradigmas de esta enfer- medad, los cuales son presentadas en esta revisión.

Molecular identification of Bartonella bacilliformis in ticks collected from two species of wild mammals in Madre de Dios: Peru

“…Bartonella bacilliformis is the most frequent species of Bartonella in Peru and the responsible for Carrion’s disease a neglected tropical infection endemic in this country [3, 9]. …”

“…Oroya fever is characterized by acute fever and hemolytic anemia with case fatality rates up to 88% in untreated patients. In contrast, the verruga peruana presents as angiogenic benign skin lesions which are self-limiting and can persist for 6 months [7–9]. However, most patients with Verruga Peruana do not have a clear previous history of febrile illness [7, 10].…”

“…and humans are considered the only reservoir host [3, 9]. Due to the favorable ecological conditions for the Lutzomyia spp., the disease has been historically restricted to remote valleys located between 500 and 3200 m (1600–10,500 feet) above sea level in the Andes Mountains of Peru, Colombia, and Ecuador [7, 9, 11].…”

“…and humans are considered the only reservoir host [3, 9]. Due to the favorable ecological conditions for the Lutzomyia spp., the disease has been historically restricted to remote valleys located between 500 and 3200 m (1600–10,500 feet) above sea level in the Andes Mountains of Peru, Colombia, and Ecuador [7, 9, 11]. However, in the last years, the disease has been expanding over broader geographical areas including lower altitude territories, high forest regions and valleys located in the eastern regions of the Andes representing a major health problem to populations living in endemic areas and travelers visiting these territories [12, 13].…”

Subtractive Genomic Analysis for Identification of Novel Drug Targets and Vaccine Candidates against Bartonella bacilliformis subsp. Ver097

“…General malaise, myalgia, headache, hepato/splenomegaly, palor, jaundice besides fever are the main symptoms of this phase[3]. Some patients may develop a transient immunosuppression, as a consequence of the septic state which results in the eve of other opportunistic infections, for example, toxoplasmosis, tuberculosis, salmonellosis, malaria, shigellosis, histoplasmosis and, pneumoctytocis phase [3, 9, 10].…”