Acuity and colour vision changes post intravitreal dexamethasone implant injection in patients with diabetic macular oedema

Abdel-Hay, Ahmed; Sivaprasad, Sobha; Subramanian, Ahalya; Barbur, John L.

doi:10.1371/journal.pone.0199693

Cited by 9 publications

(10 citation statements)

References 35 publications

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“…This was the case for participants with hypertension who rarely exhibit significant loss of spatial vision. However, those diagnosed with diabetes were excluded since this systemic condition is known to affect several aspects of vision 69–73 Absence of current signs of ocular disease, conventional or refractive laser surgery, corneal dystrophies or lens extraction.…”

Section: Methodsmentioning

confidence: 99%

Age‐related normal limits for spatial vision

Keuken

Subramanian

Mueller‐Schotte

et al. 2022

Ophthalmic Physiologic Optic

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To establish age-related, normal limits of monocular and binocular spatial vision under photopic and mesopic conditions.Methods: Photopic and mesopic visual acuity (VA) and contrast thresholds (CTs)were measured with both positive and negative contrast optotypes under binocular and monocular viewing conditions using the Acuity-Plus (AP) test. The experiments were carried out on participants (age range from 10 to 86 years), who met pre-established, normal sight criteria. Mean and ± 2.5σ limits were calculated within each 5-year subgroup. A biologically meaningful model was then fitted to predict mean values and upper and lower threshold limits for VA and CT as a function of age. The best-fit model parameters describe normal aging of spatial vision for each of the 16 experimental conditions investigated.Results: Out of the 382 participants recruited for this study, 285 participants passed the selection criteria for normal aging. Log transforms were applied to ensure approximate normal distributions. Outliers were also removed for each of the 16 stimulus conditions investigated based on the ±2.5σ limit criterion. VA, CTs and the overall variability were found to be age-invariant up to ~50 years in the photopic condition. A lower, age-invariant limit of ~30 years was more appropriate for the mesopic range with a gradual, but accelerating increase in both mean thresholds and intersubject variability above this age. Binocular thresholds were smaller and much less variable when compared to the thresholds measured in either eye.Results with negative contrast optotypes were significantly better than the corresponding results measured with positive contrast (p < 0.004). Conclusions:This project has established the expected age limits of spatial vision for monocular and binocular viewing under photopic and high mesopic lighting with both positive and negative contrast optotypes using a single test, which can be implemented either in the clinic or in an occupational setting.

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Section: Methodsmentioning

confidence: 99%

Age‐related normal limits for spatial vision

Keuken

Subramanian

Mueller‐Schotte

et al. 2022

Ophthalmic Physiologic Optic

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“…Interestingly, Dex implant was demonstrated to be effective even in improving other functional aspects, such as color vision. The analysis of both red-green (RG) and yellow-blue (YB) color thresholds variation after Dex implant was performed in 14 patients with DME [85]. Twenty-four weeks after injection, the RG threshold improved significantly, while YB ones remained substantially unchanged after treatment.…”

Section: Evidence Of the Efficacy Of Dex In Diabetic Macular Edemamentioning

confidence: 99%

Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature

et al. 2020

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Drug delivery into the vitreous chamber remains a great challenge in the pharmaceutical industry due to the complex anatomy and physiology of the eye. Intravitreal injection is the mainstream route of drug administration to the posterior segment of the eye. The purpose of this review is to assess the current literature about the widening use of the intravitreal 0.7 mg dexamethasone (Dex) implant, and to provide a comprehensive collection of all the ocular disorders that benefit from Dex administration. Although anti-vascular endothelial growth-factors (VEGFs) have been largely indicated as a first-choice level, the Dex implant represents an important treatment option, especially in selected cases, such as vitrectomized eyes or patients in whom anti-VEGF failed or are contraindicated. In this article, the safety profile as well as the list of the possible complications related to intravitreal Dex injection are also discussed.

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“…The visual function is also affected 1,2,6,7 . Younger adults may also be affected by systemic diseases 8,9 . Glaucoma, cataract, macular degeneration, and diabetes are the common causes of acquired color vision defects 1…”

Section: Introductionmentioning

confidence: 99%

Quantitative scoring methods of the Farnsworth D15 and Waggoner computerized D15 color vision tests in clinical practice

Almustanyir

Alduhayan

Alhassan

et al. 2021

Color Research & Application

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The Farnsworth D15 (FR‐D15) color vision test is generally used to determine whether individuals with color vision defects have good color discrimination to perform their jobs safely. The Waggoner computerized color vision test D15 (WC‐D15) is a computerized version of the FR‐D15 test. This study aimed to evaluate the color differences vectors analyses (CDV) quantitative scoring in clinical practice using the FR‐D15 and WC‐D15 color vision tests. Fifty‐nine individuals with congenital red‐green color vision deficiency participated in this study. All participants were screened with the Ishihara, Waggoner Pseudoisochromatic plates, and City University Tests. Participants also completed FR‐D15 and WC‐D15 tests. The number of crossings, and CDV indices, including the confusion index, total error score, specificity index, and angle were assessed. There were significant correlations between the number of crossings and each of the CDV parameters. Results of both D15 tests showed that defects classified by confusion angles improve with an increase in crossings. The correct diagnosis rate improved when the criterion of failure was relaxed compared to the generally accepted criteria of ≥2. A CDV angle of either 0° or −3° accurately classifies defects as protan or deutan. Quantitative measurements of the FR‐D15 and WC‐D15 color vision tests showed good results in detecting color vision deficiency and diagnosing the type of defect. The CDV parameters positively correlated with the traditional evaluation of the defect's presence by counting the crossings. It is more accurate for clinicians to interpret their results using the CDV parameters.

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Acuity and colour vision changes post intravitreal dexamethasone implant injection in patients with diabetic macular oedema

Cited by 9 publications

References 35 publications

Age‐related normal limits for spatial vision

Age‐related normal limits for spatial vision

Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature

Quantitative scoring methods of the Farnsworth D15 and Waggoner computerized D15 color vision tests in clinical practice

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