This article presents an overview of the clinical trials literature on complementary and alternative medicine for traumatic brain injury. In searches of PubMed and the Allied and Complementary Medicine Database, trials of acupuncture, acupressure, creatine, homeopathy, hyperbaric oxygen therapy, mindfulness-based practices, music therapy, neurotherapy, Tai Chi, and yoga were identified. Because of the high risk of bias in most of the studies reviewed, the evidence base is inadequate to recommend any specific complementary and alternative medicine treatments for traumatic brain injury, although promising findings were identified for a number of treatments. Safety data on many of the interventions were lacking.