Acupuncture Stimulation at GB34 Restores MPTP‐Induced Neurogenesis Impairment in the Subventricular Zone of Mice

Jeon, Hyongjun; Ryu, Sun Young; Kim, Dong-Soo; Koo, Sungtae; Ha, Ki‐Tae; Kim, Seungtae

doi:10.1155/2017/3971675

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…Yeo and colleagues [34] performed a small, randomized, sham-controlled trial comparing twelve patients with PD to healthy controls specifically targeting the GB34 acupoint, which is thought to cure disease of the lower extremities (including pain and weakness), muscles, and gallbladder. Additionally, this region has demonstrated neuroprotection in MPTP mouse models [35][36][37].…”

Section: Imaging and Acupuncture In Parkinson Diseasementioning

confidence: 99%

Complementary Therapies in Parkinson Disease: a Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis

Deuel

Seeberger

2020

Neurotherapeutics

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Parkinson disease (PD) is a progressive neurodegenerative condition characterized by bradykinesia, rigidity, resting tremor, and postural instability. Non-motor symptoms, including pain, fatigue, insomnia, anxiety, and depression to name a few, are increasingly recognized and often just as disabling at motor symptoms. The mainstay of treatment is dopamine replacement; however, the beneficial effects tend to wane over time with disease progression, and patients often experience motor fluctuations and medication side effects. The lack of a disease-modifying intervention and the shortcomings of traditional symptomatic medications have led many patients to pursue complementary therapies to alleviate motor and non-motor symptoms associated with PD. The term complementary implies that the therapy is used along with conventional medicine and may include supplements, manipulative treatments (chiropractic, massage), exercise-based programs, and mind-body practices. As these practices become more widespread in Western medicine, there is a growing interest in evaluating their effects on a number of medical conditions, PD included. In this review, we provide an update on clinical trials that have evaluated the effectiveness of complementary treatments for patients with PD, specifically focusing on acupuncture, Tai Chi, Qi Gong, yoga, and cannabis.

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Section: Imaging and Acupuncture In Parkinson Diseasementioning

confidence: 99%

Complementary Therapies in Parkinson Disease: a Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis

Deuel

Seeberger

2020

Neurotherapeutics

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“…It also enhances the availability of synaptic dopamine [16], decreases the effective dose of levodopa, and relieves side effects [17]. Thus, GB34 is an appropriate acupoint to treat PD [18–21].…”

Section: Introductionmentioning

confidence: 99%

Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

Hwang

Song

Ahn

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Parkinson's disease is the second most common neurodegenerative disease. Patients with Parkinson's disease can be treated with a combination of acupuncture and herbal medicine, but studies on the synergistic effects of the combined treatment have not yet been conducted. Thus, we subjected an MPTP-induced Parkinson's disease mouse model to the combined treatment. We used acupoint GB34 for acupuncture and modified Chunggantang (KD5040) as the herbal medicine, as they have been reported to be effective in Parkinson's disease. We investigated the suboptimal dose of KD5040 and then used this dose in the combined treatment. The results showed that the combined treatment had a synergistic effect on improvements in abnormal motor function and neurodegeneration compared with the use of acupuncture or herbal medicine alone. The combined treatment also had a neuroprotective effect via the PI3K/AKT and MAPK/ERK signaling pathways. These findings suggest that the combined treatment with acupuncture and KD5040 can help improve the symptoms of Parkinson's disease.

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“…Therefore, the results presented above suggest that BDNF/TrkB and their downstream signaling pathways may mediate the neuroprotective effects of acupuncture in PD treatment. Besides, acupuncture has been found to increase the number of 5-bromo-2 ′ -deoxyuridine-(BrdU) positive cells and to restore neurogenesis in the subventricular zone [71], which provides a new pathway for studying the molecular mechanisms of acupuncture treatment for PD.…”

Section: Apoptosismentioning

confidence: 99%

Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit

et al. 2021

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Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease caused by degeneration of dopaminergic neurons in the substantia nigra. Existing pharmaceutical treatments offer alleviation of symptoms but cannot delay disease progression and are often associated with significant side effects. Clinical studies have demonstrated that acupuncture may be beneficial for PD treatment, particularly in terms of ameliorating PD symptoms when combined with anti-PD medication, reducing the required dose of medication and associated side effects. During early stages of PD, acupuncture may even be used to replace medication. It has also been found that acupuncture can protect dopaminergic neurons from degeneration via antioxidative stress, anti-inflammatory, and antiapoptotic pathways as well as modulating the neurotransmitter balance in the basal ganglia circuit. Here, we review current studies and reflect on the potential of acupuncture as a novel and effective treatment strategy for PD. We found that particularly during the early stages, acupuncture may reduce neurodegeneration of dopaminergic neurons and regulate the balance of the dopaminergic circuit, thus delaying the progression of the disease. The benefits of acupuncture will need to be further verified through basic and clinical studies.

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Acupuncture Stimulation at GB34 Restores MPTP‐Induced Neurogenesis Impairment in the Subventricular Zone of Mice

Cited by 11 publications

References 25 publications

Complementary Therapies in Parkinson Disease: a Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis

Complementary Therapies in Parkinson Disease: a Review of Acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis

Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit

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