Acupuncture Stimulation of Taichong (Liv3) and Hegu (LI4) Modulates the Default Mode Network Activity in Alzheimer’s Disease

Liang, Peipeng; Wang, Zhi­qun; Qian, Tianyi; Li, Kuncheng

doi:10.1177/1533317514536600

Cited by 68 publications

(54 citation statements)

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“…Studies have partially clarified the mechanisms by which acupuncture can prevent AD through anti-inflammatory (Ding et al, 2017), anti-oxidative (Sutalangka et al, 2013), and anti-apoptotic effects (Guo et al, 2015(Guo et al, , 2016. Moreover, acupuncture can modulate the functional activity and connectivity of specific cognition-related areas of the brain in AD patients (Wang et al, 2012Liang et al, 2014;Zheng et al, 2018). However, the effect of manual acupuncture (MA) on CBF in AD therapy and the specifics of its molecular mechanisms are still not well known.…”

Section: Introductionmentioning

confidence: 99%

Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF

et al. 2020

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Background: The astrocytic phospholipase A 2 (PLA 2 )-arachidonic acid (AA) pathway is crucial in understanding the reduction of cerebral blood flow (CBF) prior to cognitive deterioration. In complementary and alternative medicine, manual acupuncture (MA) is used as one of the most important therapies for Alzheimer's disease (AD). The beneficial effects of MA on CBF were reported in our previous study. However, the underlying molecular mechanism remains largely elusive.Objective: To investigate the effect of MA on the astrocytic PLA 2 -AA pathway in SAMP8 mice hippocampi.Methods: SAMP8 mice were divided into the SAMP8 control (Pc) group, the SAMP8 MA (Pm) group and the SAMP8 donepezil (Pd) group. SAMR1 mice were used as the SAMRl control (Rc) group. Mice in the Pd group were treated with donepezil hydrochloride at 0.65 µg/g. In the Pm group, MA was applied at Baihui (GV20) and Yintang (GV29) for 20 min. The above treatments were administered once a day for 26 consecutive days. The Morris water maze was applied to assess spatial learning and memory. Immunofluorescence staining, western blot and liquid chromatographytandem mass spectrometry were used to investigate the expression of related proteins and measure the contents of the metabolic intermediates of the PLA 2 -AA pathway.Results: Compared with that in the Rc group, the escape latency in the Pc group significantly increased (p < 0.01); whereas, the platform crossover number and percentage of time and swimming distance in the platform quadrant decreased (p < 0.01). The hippocampal expression of PLA 2 , cyclooxygenase-1, cytochrome P450 proteins 2C23 and the levels of AA, prostaglandin E 2 and epoxyeicosatrienoic acids of the Pc group was drastically higher than that in the Rc group (p < 0.01). These changes were reversed by MA and donepezil (p < 0.01 or p < 0.05). Frontiers in Neuroscience | www.frontiersin.org February 2020 | Volume 13 | Article 1354 Ding et al. Acupuncture Regulates PLA 2 -AA PathwayConclusion: MA can effectively improve the learning and memory abilities of SAMP8 mice and has a negative regulatory effect on the PLA 2 -AA pathway. We propose that the increase of the arterial tone, which is induced by the inhibition of vasodilatory pathway, may be a reason for the beneficial effect of MA on CBF.Keywords: manual acupuncture, Alzheimer's disease, astrocyte, hippocampus, phospholipase A 2 , arachidonic acid, cerebral blood flow absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Section: Introductionmentioning

confidence: 99%

Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF

et al. 2020

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“…A meta-analysis not only supports the high safety of the technique but also indicates that acupuncture is more effective than drugs at improving AD patients' ability to carry out their daily lives and may even enhance the effects of drug treatments [ 2 ]. fMRI studies have shown that acupuncture can enhance hippocampal connectivity [ 3 ], modulate default mode network activity [ 4 ], and activate certain cognitive-related regions in AD patients [ 5 ]. The positive effect of acupuncture on blood perfusion and glycol metabolism in certain brain areas in a rat model of AD has also been certified by PET studies [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice

Ding

Jiang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective To investigate the effect of manual acupuncture (MA) on NLRP3 inflammasome-related proteins. Methods SAMP8 mice were randomly divided into Alzheimer's disease (AD) group, the MA group, and the medicine (M) group. Mice in the M group were treated with donepezil hydrochloride at 0.65 μg/g. In the MA group, MA was applied on Baihui (GV20) and Yintang (GV29) for 20 min and then pricked at Shuigou (GV26). The Morris water maze was applied to assess spatial learning and memory. Immunohistochemical staining and western blot analysis were used to observe the expression of NLRP3 inflammasome-related proteins. ResultsCompared with the normal (N) control group, spatial learning and the memory capabilities of the AD group significantly decreased (p < 0.01). The number of NLRP3, ASC, Caspase-1, and IL-1β positively stained cells in the AD group was higher than the N group, and the relative expression levels of the above proteins were significantly higher than those in the N group (p < 0.01). These changes were reversed by both MA and donepezil (p < 0.01). Conclusion MA can improve the learning and memory capabilities of SAMP8 mice. The negative regulation of the NLRP3/Caspase-1 pathway in the hippocampus may be a possible mechanism of MA in the treatment of AD.

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“…The psychological assessment on the participants was performed in 4 studies [21, 31, 46, 92, 93]. The self-rating depression scale (SDS) and the self-rating anxiety scale (SAS) were used in 2 studies [31, 46].…”

Section: Resultsmentioning

confidence: 99%

“…38 studies [11, 13, 15, 21, 31, 36, 42, 43, 46, 54, 57, 64, 65, 68, 73, 76, 78, 81, 87, 93, 100, 102, 104, 106, 110–121, 123, 128, 133, 135, 141, 148, 151, 153, 156, 158, 165, 174] excluded the participants with head trauma, and some studies [24, 46, 54, 73, 100, 121, 122] excluded the participants suffering from pain (including headache and dysmenorrhea).…”

Section: Resultsmentioning

confidence: 99%

The Status of the Quality Control in Acupuncture‐Neuroimaging Studies

Qiu

Jing

Sun

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Using neuroimaging techniques to explore the central mechanism of acupuncture gains increasing attention, but the quality control of acupuncture-neuroimaging study remains to be improved. We searched the PubMed Database during 1995 to 2014. The original English articles with neuroimaging scan performed on human beings were included. The data involved quality control including the author, sample size, characteristics of the participant, neuroimaging technology, and acupuncture intervention were extracted and analyzed. The rigorous inclusion and exclusion criteria are important guaranty for the participants' homogeneity. The standard operation process of acupuncture and the stricter requirement for acupuncturist play significant role in quality control. More attention should be paid to the quality control in future studies to improve the reproducibility and reliability of the acupuncture-neuroimaging studies.

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Acupuncture Stimulation of Taichong (Liv3) and Hegu (LI4) Modulates the Default Mode Network Activity in Alzheimer’s Disease

Abstract: It was found that the acupuncture stimulation could modulate the DMN activity in AD. The current findings suggest that the acupuncture treatment on the relative earlier AD patients might have a better therapy effect.

Cited by 68 publications

References 34 publications

Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF

Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF

Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice

The Status of the Quality Control in Acupuncture‐Neuroimaging Studies

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