Acupuncture therapy for the treatment of stable angina pectoris: An updated meta-analysis of randomized controlled trials

Liu, Yuan; Meng, Haoyu; Khurwolah, Mohammad Reeaze; Liu, Jia‐Bao; Tang, Heng Yuan; Aa, Nan; Yang, Zhijian

doi:10.1016/j.ctcp.2018.12.012

Cited by 32 publications

(33 citation statements)

References 22 publications

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“…Although we did not assess the effective rate of acupuncture therapy in SAP, our results showed that acupuncture therapies on DAM could be effective in relieving SAP. Liu et al [23] evaluated the effect of simple acupuncture and acupuncture combined with medicine and we both produced the results that acupuncture therapy could improve anginal symptoms, ECG results as adjunctive therapy. Their results also pointed out that acupuncture therapy reduced intake rate of nitroglycerin, and our results presented that acupuncture therapy at DAM could decrease consumption of nitroglycerin.…”

Section: Discussionmentioning

confidence: 99%

“…However, previous clinical trials [12,[18][19][20] came to different conclusions in the difference of effect in acupuncture on disease-affected meridian (DAM), sham acupoints and acupuncture on nonaffected meridian (NAM). The six published meta-analyses [21][22][23][24][25][26] discussed the effect of acupuncture on all acupoints, not acupuncture on DAM. Considering the importance of acupoint selection in treatment and growing number of randomized controlled trials (RCTs) of acupuncture therapy on DAM for SAP, we conducted this systematic review and meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture therapy for stable angina pectoris: a systematic review and meta-analysis

Chen¹,

Wang²,

Xue³

et al. 2020

Preprint

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Background Stable angina pectoris (SAP) is a common cardiovascular disease, which brings health burden to society. Acupuncture therapy is effective in improving SAP as adjunctive therapy, nevertheless, there were controversies on the effect of acupuncture on disease-affected meridian (DAM), sham acupoints and nonaffected meridian (NAM). This study evaluated the effect of acupuncture on DAM as adjunctive therapy, and the difference in acupuncture on DAM, sham acupoints, and nonaffected meridian NAM. Methods Thirteen online databases were searched from inception to December 2, 2019. Risk of bias and quality of evidence for outcomes were respectively assessed by the Cochrane risk of bias assessment tool and the GRADE approach. RevMan 5.3 was adopted to conduct meta-analysis. Results Thirteen RCTs including 1026 participants were included in this study. Acupuncture therapy could be effective in the improvement of angina severity, ECG results, 6-MWT, SAQ results (physical limitation, angina stability, angina frequency, treatment satisfaction, disease perception), anxiety, HRV (LF, LF/HF), ET, CRP, and reduction of nitroglycerin intake. Acupuncture on DAM could be more beneficial than acupuncture on sham acupoints in aspects of angina severity, 6-MWT, SAQ results (angina stability, angina frequency, treatment satisfaction, disease perception). Compared to acupuncture in NAM, acupuncture on DAM could be more effective in SAQ results (angina stability, angina frequency, treatment satisfaction). Moreover, acupuncture on DAM did not increase the risk of dropout and adverse effect. Conclusions Acupuncture on DAM could effectively improving SAP, and it could be more effective compared with acupuncture on sham acupoints or NAM. However, these conclusions were limited by low-quality of most of included studies. Registration Open Science Framework registration (DOI: 10.17605/OSF.IO/F9DTW).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acupuncture therapy for stable angina pectoris: a systematic review and meta-analysis

Chen¹,

Wang²,

Xue³

et al. 2020

Preprint

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“…A large number of clinical reports have proved that acupuncture therapy can effectively treat a variety of cardiovascular diseases, such as CHD, hypertension, heart failure, arrhythmia and so on. [ 5 – 8 ] Currently published studies show that acupuncture can improve the symptoms of patients with AP, and has a good effect on reducing the frequency of AP. [ 9 ] However, the evidence of acupuncture treatment of AP is far from meeting the modern clinical norms.…”

Section: Introductionmentioning

confidence: 99%

Acupoint for angina pectoris

et al. 2021

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Introduction: Patients with angina pectoris (AP) often experience heavy psychological distress, especially anxiety and depression, which results in poorer quality of life, shorter survival time. Acupoint therapies, including massage, acupuncture, acupoints injection, acupressure, and moxibustion, showed clinical and long-lasting benefits for AP, but the efficiency of acupoint therapies was poorly evaluated. The current review is attempted to evaluate the efficacy and safety of the different acupoint-based therapies for AP. Methods and analysis: A literature search will be conducted in MEDLINE, EMBASE, Web of Science, Cochrane Library, Web of Science, PubMed, Science Direct, Wan Fang Data Knowledge Service Platform, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP database), and China National Knowledge Infrastructure (CNKI). Observational studies regarding the association between liver cancer and depression and anxiety written in English or Chinese will be included. Study inclusion, data extraction, and quality assessment will be performed independently by 2 reviewers. We will use RevMan V.5.0 and STATA V.12.0 software for statistical analysis. The I 2 test will be used to identify the extent of heterogeneity. Publication bias will be assessed by generating a funnel plot and performing the Begg and Egger test. The quality of the systematic review will be evaluated using the Measurement Tool to Assess Systematic Reviews (AMSTAR) and Grading of Recommendations Assessment Development and Evaluation (GRADE) criteria. With the permitted numeric data, we will carry out a meta-analysis. Results: This study will provide a high-quality synthesis of pain VAS and functional disability or the quality of life, the success treatment rate, the recurrent rate and the complications rate to assess the effectiveness and safety of acupoint for AP patients. This systematic review will provide evidence to judge whether acupoint is an effective intervention for patients with AP. Conclusion: This systematic review and meta-analysis will provide evidence to judge whether acupoint is an effective intervention for patients with AP and provide evidence for designing early targeted interventions for high-risk survivors that can attenuate negative reactions. PROSPERO registration number: 10.17605/OSF.IO/VNXWE.

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“…The Heart Meridian connects with the heart directly, and the Lung Meridian indirectly associates with the heart. Both of these two meridians can be used for cardiovascular diseases in clinical practice [15,16]. Based on the theory of Meridian-Viscera Association, our previous study found that not only the acupoints on the Heart Meridian and Pericardium Meridian, but also the acupoints on the Lung Meridian could improve the symptoms and the Qol of CSAP patients.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for chronic stable angina pectoris based on the theory of Meridian-Viscera Association: study protocol for a multicenter randomized controlled trial

Yang

Wen

et al. 2020

Trials

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Background Acupuncture has long been used to treat chronic stable angina pectoris (CSAP), but the acupuncture prescription for CSAP varies. This trial will compare the therapeutic effects between the acupoints on the Heart Meridian and the acupoints on the Lung Meridian for treating CSAP, so as to provide a better prescription for acupuncture treatment of CSAP. Methods This is a multicenter randomized controlled trial. A total of 148 CSAP patients will be randomly allocated into two groups through central randomization in a 1:1 ratio. This trial will include a 2-week screening period, a 4-week treatment period, and a 4-week follow-up period. The primary outcome is the frequency of angina attacks from baseline to 4 weeks after inclusion. Secondary outcomes include the frequency of angina attacks from baseline to 4 weeks after acupuncture treatment, the pain intensity of angina, total ischemia burden, heart rate variability, QT dispersion, the score of Seattle Angina Questionnaire, and the score of Short-Form of McGill Pain Questionnaire. These outcome measures will be evaluated at baseline, at the end of acupuncture treatment, and at the end of follow-up. Discussion We hypothesize that the effectiveness of puncturing at acupoints on the Heart Meridian will not be the same as those on the Lung Meridian. The results will provide further evidence of Meridian-Viscera Association theory and references for acupoints selection in the clinical practice. Trial registration Chinese Clinical Trial Registry ChiCTR1900025804. Registered on September 9, 2019

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Acupuncture therapy for the treatment of stable angina pectoris: An updated meta-analysis of randomized controlled trials

Cited by 32 publications

References 22 publications

Acupuncture therapy for stable angina pectoris: a systematic review and meta-analysis

Acupuncture therapy for stable angina pectoris: a systematic review and meta-analysis

Acupoint for angina pectoris

Acupuncture for chronic stable angina pectoris based on the theory of Meridian-Viscera Association: study protocol for a multicenter randomized controlled trial

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