Acupuncture Upregulates G Protein Coupled Activity in Samp8 Mice

Luo, Bin; Zhao, Lan; Zhang, Xuezhu; Kan, Bohong; Liu, Yunhe; Jia, Yujie; Jing-xian, Han; Yu, Jianchun

doi:10.1136/acupmed-2016-011139

Cited by 13 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the four rats models, intraperitoneal injection of scopolamine (SCO) was used to establish an AD model in one study [29] and intracerebroventricular (ICV) injection of Aβ 1-42 was used in two studies [34,35], and the ICV injection of Aβ 1-40 was used in the rest one study [38]. In mice models, three studies adopted APP/PS1 double transgenic mice model [28,33,39], and the rest used SAMP8 mice model as mentioned above [27,32,36,37,40].…”

Section: Model Preparation Methodsmentioning

confidence: 99%

“…e quality assessments of 12 included papers are illustrated in Tables 3 and 4, and the score of the study quality ranged from 2 to 8 out of a total 10 points. Among the 12 studies, only two studies described the specific random method [37,39]. Similarly, only two studies clearly showed that the baseline characteristics had been evaluated or adjusted among the groups before the intervention [35,39], and two studies reported that caregivers or investigators were blinded during the study [29,33], respectively.…”

Section: Study Quality Evaluationmentioning

confidence: 99%

“…Eleven studies [27][28][29][32][33][34][35][36][37][38][39] adopted escape latency as an outcome indicator, and all reported a positive effect of verum-acupuncture in reducing escape latency. However, there was a high heterogeneity among the studies (p < 0.00001, I 2 � 84%), and random effects model thereby was performed for analysis.…”

Section: Escape Latencymentioning

confidence: 99%

“…Platform crossover numbers were adopted as an outcome in eight studies [27,28,[33][34][35][37][38][39], and all of these studies reported the positive effect of verum-acupuncture in increasing platform crossover numbers. However, there was a heterogeneity among the studies (p < 0.00001, I 2 � 91%) and random [28] U N U Y U N Y Y Y Y 5 Lee et al [29] U N U Y Y U Y Y Y Y 6 Li et al [32] U N U Y U N Y Y Y Y 5 Lin et al [33] U N U Y Y U Y Y Y Y 6 Yu et al [34] U N U Y U U Y Y Y Y 5 Li et al [35] U Y U Y U N Y Y Y Y 6 Zhao et al [36] U N U Y U N Y Y Y Y 5 Luo et al [37] Y N U Y U N Y Y Y Y 6 Guo et al [38] U N U Y U U Y Y Y Y 5 Liu et al [39] Y Y U Y U U Y Y Y Y 7 Li et al [40] U N U Y U N Y Y Y Y 5…”

Section: Platform Crossover Numbersmentioning

confidence: 99%

“…Five studies [27,32,34,37,38] adopted time spent in the original platform quadrant as an outcome, and all of these studies reported a significantly better effect of verum-acupuncture than sham-acupuncture. Random effects model was used for analysis due to the high heterogeneity (p < 0.00001, I 2 � 90%).…”

Section: Time Spent In the Original Platform Quadrantmentioning

confidence: 99%

See 4 more Smart Citations

Verum‐ versus Sham‐Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta‐Analysis

Zhao

Zheng

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Background. Alzheimer’s disease (AD) is a common health condition affecting senile people and leads to severe cognitive dysfunctions. Acupuncture has been shown to be a possible alternative natural remedy for AD in some animal studies. Objective. To perform a systematic review to identify the effect of verum-acupuncture compared with sham-acupuncture on learning and memory performance among animal models of AD. Methods. Experimental animal studies of treating AD via verum- and sham- acupuncture were searched in nine electronic databases, including Sciverse ScienceDirect, PubMed, Springer, Ebsco Medline, AMED, EMBASE (Elsevier), Scopus (Elsevier), PsycINFO (ProQuest), and OVID from the dates of the databases’ inception to June 2019. The Morris water maze test was considered as an outcome measure. The software Revman 5.3 and Stata 16.0 were used to conduct the meta-analysis. Heterogeneity was examined by using I2 statistics. The publication bias was assessed via Begg’s test by Stata 16.0. Results. Twelve studies involving 229 animals met the inclusion criteria. Most of the studies had a moderate quality according to SYRCLE's risk of bias tool for animal studies. The results of the meta-analysis indicated that verum-acupuncture could reduce the escape latency (MD = −12.90, 95% CI (−17.08, −8.71), p<0.001) and increase the time spent in the original platform quadrant (MD = 7.28, 95% CI (4.23, 10.33), p<0.001) and frequency of the crossing former platform (MD = 2.01, 95% CI (1.53, 2.50), p<0.001) compared with the sham-acupuncture. Conclusions. Acupuncture is effective in improving cognitive functions in AD animal models, and this benefit is more than just a placebo effect. Further clinical trials are needed to confirm the findings.

show abstract

Section: Model Preparation Methodsmentioning

confidence: 99%

Section: Study Quality Evaluationmentioning

confidence: 99%

Section: Escape Latencymentioning

confidence: 99%

Section: Platform Crossover Numbersmentioning

confidence: 99%

Section: Time Spent In the Original Platform Quadrantmentioning

confidence: 99%

See 3 more Smart Citations

Verum‐ versus Sham‐Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta‐Analysis

Zhao

Zheng

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

Acupuncture therapy for Alzheimer's disease: The effectiveness and potential mechanisms

Yin

et al. 2021

The Anatomical Record

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a common neurodegenerative disease that accounts for approximately 70% of dementia. Following the global escalation of the aging process, the morbidity of AD is increasing rapidly. The current treatment for AD is mainly limited to medications, such as acetylcholinesterase inhibitors. However, the efficacy of acetylcholinesterase inhibitors in improving memory and cognitive functions is not satisfactory. It is a challenge to find an effective alternative therapy for ameliorating AD symptoms. As an important therapeutic technique in traditional Chinese medicine, acupuncture has been proved effective in treating many neurologic diseases including AD. The efficacy of acupuncture is also acknowledged by the National Institutes of Health of the United States. Here, we summarized the effectiveness of acupuncture for treating AD. Especially, the role of acupuncture at certain acupuncture points in modulating the brain function through meridians activity based on Chinese meridian theory is discussed. How acupuncture at a certain acupoint can improve AD symptoms is also described. Furthermore, the possible molecular mechanisms of acupuncture for AD are reviewed, and the role of acupuncture in modulating signaling molecules in neural protection and homeostasis is highlighted. This study may help to understand the theoretical basis and potential molecular mechanisms of acupuncture therapy for AD.

show abstract

Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Liu¹,

Pan²,

Zhenzhen³

et al. 2023

Heliyon

View full text Add to dashboard Cite

Acupuncture Upregulates G Protein Coupled Activity in Samp8 Mice

Abstract: acupuncture attenuates cognitive deficits in a mouse model of AD via upregulation of G protein activity and stabilisation of the cellular signal.

Cited by 13 publications

References 20 publications

Verum‐ versus Sham‐Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta‐Analysis

Verum‐ versus Sham‐Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta‐Analysis

Acupuncture therapy for Alzheimer's disease: The effectiveness and potential mechanisms

Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia

Contact Info

Product

Resources

About