Acute alcohol intoxication in socially drinking female and male offspring of alcoholic fathers.

Savoie, Tammy M.; Emory, Eugene K.; Moody–Thomas, Sarah

doi:10.15288/jsa.1988.49.430

Cited by 48 publications

(42 citation statements)

References 18 publications

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“…Additionally, subjects with at least 50% Native American heritage reported feeling fewer effects of intoxication than those with less than 50% Native American heritage. These findings are consistent with several studies using the Subjective High Assessment Scale, which demonstrated that groups at higher risk for alcoholism have a less intense subjective response to alcohol (9)(10)(11)(12)(13) and that groups at lower genetic risk for alcoholism have a more intense subjective response to alcohol (16,17).…”

Section: Discussionsupporting

confidence: 92%

The firewater myth and response to alcohol in Mission Indians

Garcia‐Andrade

Wall²,

Ehlers³

1997

AJP

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Section: Discussionsupporting

confidence: 92%

The firewater myth and response to alcohol in Mission Indians

Garcia‐Andrade

Wall²,

Ehlers³

1997

AJP

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“…The data are consistent with Lex et al (1994) who found that the FHP group had lower scores on the "High," and "Drunk" items, and noted less intense "Alcohol Effects" than the FHNs. Further support for differences in subjective ratings of LR between FHN and FHP women come from Savoie et al (1988) who reported that FHP women appeared to have lower ratings of central stimulant effects of alcohol (i.e., Light Headed, Head Spinning, Dizzy, Ringing/Buzzing) at peak BAC than the FHN group. Finally, in an evaluation by , a comparison of daughters of alcoholics and controls revealed possible lower SHAS7 scores for the FHP group.…”

Section: Discussionmentioning

confidence: 99%

“…The findings are consistent with most previous data on daughters of alcoholics. These earlier investigations often involved small samples (e.g., Evans and Levin, 2003;Lex et al, 1988Lex et al, , 1994Savoie et al, 1988;, or evaluated the similarity between sons and daughters of alcoholics without directly comparing FHP and FHN women (e.g., Schuckit et al, 2004). While these studies indicated that a low LR was more likely to be observed in FHP compared to FHN women, this is the first investigation to support this conclusion where the women were carefully matched on variables that may affect LR (e.g., age, drinking history), while also minimizing the effect of other factors that are possibly related to the risk for AUDs (e.g., Asian background).…”

Section: Discussionmentioning

confidence: 99%

“…In a subsequent report, that did not include matched participants, 7 FHPs rated themselves as feeling less "Drunk" and "High," as well as less intense "Alcohol Effects" than 10 FHNs following alcohol, but demonstrated greater impairment with longer visual search response times on the Divided Attention Task (Lex et al, 1994). Another study of six unmatched pairs of FHP and FHN women revealed no significant differentials on alcohol-related changes in mood state, perceived physiological sensations, or performance on a grooved-pegboard task, although the FHPs did consistently report lower scores on central stimulant effects and were less impaired on a finger-tapping task following ethanol (Savoie et al, 1988). An investigation of 38 FHP women, 75 FHP men, and 68 FHN males also presented pilot data on 11 FHN female controls .…”

Section: Introductionmentioning

confidence: 95%

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The level of response to alcohol in daughters of alcoholics and controls

Eng

Schuckit

Smith

2005

Drug and Alcohol Dependence

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Background: The low level of response (LR) to alcohol is a genetically influenced characteristic related to the development of alcohol use disorders (AUDs). This phenotype is found in men with a family history (FH) of alcoholism, predicts future AUDs, and has heritabilities as high as 60%. However, despite evidence of genetic influences for AUDs in both sexes, the majority of studies evaluating differences in LR across high-and low-risk groups have been conducted on males, and it is unclear how generalizable these results are to women. Methods: Twenty-five women who are family history positive (FHP) for alcohol dependence were matched with 25 women with no FH of alcoholism (FHN) on factors that may impact LR. Using an alcohol challenge paradigm, data on the reaction to a moderate dose of alcohol were gathered over a period of 3.5 h. Assessments included breath alcohol concentrations (BrACs), the Subjective High Assessment Scale (SHAS), as well as body sway or static ataxia. Results: Family history positives reported lower subjective intoxication than FHNs. In addition, when body sway scores were corrected for skewness, FHPs had significantly lower scores on alcohol-related changes in lateral sway. These differences remained after considering the effects of drinking history and BrAC values. Conclusions: This study evaluated the LR to alcohol in the largest sample of alcohol challenges in matched FHP and FHN women to date. Overall, the findings are consistent with most data from earlier investigations of smaller sized samples of FHP women. The results suggest that, similar to sons of alcoholics, a low LR to alcohol might also be characteristic of daughters of alcoholics.

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“…Alcoholism risk has been associated with a low level of response to alcohol, as measured by subjective feelings of intoxication following an alcohol challenge (Schuckit, 1984(Schuckit, , 1994Bauer and Hesselbrock, 1993;Schuckit et al, 1996). A family history of alcoholism has also been associated with a diminished response to alcohol in nonalcoholics (Moss et al, 1989;O'Malley and Maisto, 1985;Pollock et al, 1986;Savoie et al, 1988;Schuckit, 1984;Schuckit et al, 2000;cf. Newlin and Thompson, 1990;see Pollock, 1992 for a meta-analysis).…”

Section: Discussionmentioning

confidence: 99%

GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride

Pierucci‐Lagha

Covault

Feinn

et al. 2005

Neuropsychopharmacol

133

109

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GABA A receptors are involved in the subjective effects of alcohol. Endogenous neuroactive steroids interact with GABA A receptors to mediate several behavioral effects of alcohol in rodents. Based on a haplotypic association of alcohol dependence with the gene encoding the GABA A receptor a-2 subunit (GABRA2), we examined whether GABRA2 alleles are associated with the subjective response to alcohol. We also examined whether finasteride (a 5-a steroid reductase inhibitor), which blocks the synthesis of some neuroactive steroids, reduces the subjective response to alcohol. In all, 27 healthy social drinkers (15 males) completed a randomized, double-blind, placebo-controlled study of high-dose finasteride. After being pretreated with study drug, subjects consumed three alcoholic drinks. Subjective effects were measured repeatedly over the ascending blood alcohol curve. To examine the moderating role of genetic variation in GABRA2, a single-nucleotide polymorphism that was informative in association studies was included as a factor in the analysis. Subjects homozygous for the more common A-allele (n ¼ 7) showed more subjective effects of alcohol than did individuals with one or two copies of the alcohol dependence-associated G-allele (n ¼ 20, including two homozygotes). Among the A-allele homozygotes, there was a greater reduction in several subjective effects during the finasteride session compared to the placebo session. These findings provide preliminary evidence that the risk of alcoholism associated with GABRA2 alleles may be related to differences in the subjective response to alcohol. The effects of finasteride provide indirect evidence for a mediating role of neuroactive steroids in some of the subjective effects of alcohol.

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Acute alcohol intoxication in socially drinking female and male offspring of alcoholic fathers.

Cited by 48 publications

References 18 publications

The firewater myth and response to alcohol in Mission Indians

The firewater myth and response to alcohol in Mission Indians

The level of response to alcohol in daughters of alcoholics and controls

GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride

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