Acute and chronic radiodermatitis

Robijns, Jolien; Laubach, Hans-Joachim

doi:10.1097/01.ewx.0000529960.52517.4c

Cited by 28 publications

(13 citation statements)

References 64 publications

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“…The risk factors associated with the development of radiodermatitis can be divided into patient-and treatment-related [3,7], where the letter include the type and energy of irradiation, the dose per fraction, the duration of treatment, and the total radiation dose [3]. An additional factor associated with the treatment may be concurrent chemotherapy.…”

Section: Risk Factorsmentioning

confidence: 99%

“…Immune cells, keratinocytes, fibroblasts and other cells are stimulated. Subsequent radiation doses create a vicious circle and correlate with the degree of radiodermatitis [7]. In the next phase, dry exfoliation usually occurs, which results from the disturbed balance between the division of new cells and the exfoliation of the old ones.…”

Section: Clinical Classificationmentioning

confidence: 99%

“…In the final stage, stem cells are lacking and the skin has no material from which to rebuild individual layers. Wet exfoliation and exudates occur [7]. The inflammation that started in the epidermis after the beginning of irradiation lasts for months, and even years.…”

Section: Clinical Classificationmentioning

confidence: 99%

“…The inflammation that started in the epidermis after the beginning of irradiation lasts for months, and even years. Inflammatory cytokines are secreted, including interleukin IL-1α, IL-1β, tumor necrosis factor TNF-α, TGF-β, IL-6, IL-8 [7]. The secretion of TGF-β, which is a central mediator of fibrogenesis, increases following the exposure to ionizing radiation, and it is proportional to the radiation dose delivered [8,9].…”

Section: Clinical Classificationmentioning

confidence: 99%

See 3 more Smart Citations

What is new when it comes to acute and chronic radiation-induced dermatitis in head and neck cancer patients?

Dudek

Rutkowski

Kamińska‐Winciorek

et al. 2020

Nowotwory. Journal of Oncology

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Head and neck cancer is a serious clinical and social problem. Surgery and radiotherapy play the most important role in treatment and give the chance of cure. Optimal treatment of patients with head and neck cancer should provide for the maximum destruction of cancerous tissue, saving as much healthy tissue as possible. Despite this, due to radiotherapy still almost 90% of patients develop skin symptoms. It seems that the mechanism of radiodermatitis is quite clear, but studies assume that its pathogenesis is not fully understood and there is much to be clarified. Acute and chronic dermatitis caused by radiotherapy is usually diagnosed according to clinical criteria. It seems that it would be useful to have a photographic classification that would facilitate and unify the clinical evaluation. In this article we shall summarize the current knowledge about the mechanisms of formation, risk factors, clinical classifications and methods for the prevention and treatment of acute and chronic radiation dermatitis. We have included clinical photos that depict individual stages according to the clinical classification of RTOG.

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Section: Risk Factorsmentioning

confidence: 99%

Section: Clinical Classificationmentioning

confidence: 99%

Section: Clinical Classificationmentioning

confidence: 99%

Section: Clinical Classificationmentioning

confidence: 99%

See 2 more Smart Citations

What is new when it comes to acute and chronic radiation-induced dermatitis in head and neck cancer patients?

Dudek

Rutkowski

Kamińska‐Winciorek

et al. 2020

Nowotwory. Journal of Oncology

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“…Depending on immune function and degrees of tissue injury, there is an increased risk of infection in the irradiated area. 8 The mechanism of this inflammatory reaction is not yet completely understood, but keratinocytes, fibroblasts, and endothelial cells stimulate resident as well as circulating immune cells, which produce ranks of cytokines and chemokines (eg, interleukin (IL)-1α, IL-1β, tumor necrosis factor (TNF)-α, TGF-β, IL-6, IL-8, C-C motif chemokine ligand (CCL)-4, C-X-C motif chemokine ligand (CXCL)-10 and CCL-2). The presence of these molecules results in upregulation of the expression of adhesion molecules and plays a very important role in the transendothelial migration of immune cells from circulation to the irradiated skin.…”

Section: Introductionmentioning

confidence: 99%

Overview of the Active Ingredients in Cosmetic Products for the Care of Skin That Has Been Exposed to Ionizing Radiation – Analysis of Their Effectiveness in Breast Cancer Radiotherapy

Kondziołka

Wilczyński

2021

CCID

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Treatment that uses ionizing radiation is one of the most common therapeutic methods in case of breast cancer. However, it often results in radiation dermatitis, which manifests itself, among others, as erythema, burning, itching and pain as well as dry or moist desquamation of the epidermis in the irradiated areas. The intensity of these symptoms significantly reduces the patient’s quality of life, which could affect the effectiveness of the entire therapy. There are more and more cosmetic preparations on the market for daily care of skin that has been exposed to radiation. The composition of the active ingredients in these preparations is designed to support the protective functions of the skin, delay the occurrence of the side effects of ionizing radiation, reduce their intensity, and accelerate the regeneration of the irradiated areas. Unfortunately, there is little scientific evidence of the effectiveness of the active ingredients that are contained in these preparations. This paper presents a narrative review of the most commonly used ingredients and compares them with the current state of knowledge on their effectiveness in preventing radiodermatitis.

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Topical silymarin administration for prevention of acute radiodermatitis in breast cancer patients: A randomized, double‐blind, placebo‐controlled clinical trial

Karbasforooshan

Hosseini

Elyasi

et al. 2018

Phytotherapy Research

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Radiation-induced dermatitis is one of the most common side effects of radiotherapy.Silymarin, a flavonoid extracted from the Silybum marianum, exhibits antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the efficacy of silymarin gel in prevention of radiodermatitis in patients with breast cancer. During this randomized, double-blinded, placebo-controlled clinical trial, the preventive effect of silymarin 1% gel was assessed in comparison with placebo, on radiodermatitis occurrence. Forty patients randomly received silymarin gel or placebo formulation on chest wall skin following modified radical mastectomy, once daily starting at the first day of radiotherapy for 5 weeks. Radiodermatitis severity was assessed weekly based on Radiation Therapy Oncology Group (RTOG) and National Cancer Institute Common Terminology for Adverse Events (NCI-CTCAE) criteria radiodermatits grading scale for 5 weeks. The median NCI-CTCAE and RTOG scores were significantly lower in silymarin group at the end of the third to fifth weeks (p value < 0.05). The scores increased significantly in both placebo and silymarin groups during radiotherapy, but there was a delay in radiodermatitis development and progression in silymarin group. Prophylactic administration of silymarin gel could significantly reduce the severity of radiodermatitis and delay its occurrence after 5 weeks of application.

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Acute and chronic radiodermatitis

Cited by 28 publications

References 64 publications

What is new when it comes to acute and chronic radiation-induced dermatitis in head and neck cancer patients?

What is new when it comes to acute and chronic radiation-induced dermatitis in head and neck cancer patients?

Overview of the Active Ingredients in Cosmetic Products for the Care of Skin That Has Been Exposed to Ionizing Radiation – Analysis of Their Effectiveness in Breast Cancer Radiotherapy

Topical silymarin administration for prevention of acute radiodermatitis in breast cancer patients: A randomized, double‐blind, placebo‐controlled clinical trial

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