Acute and chronic toxicity of triphenyltin hydroxide to fathead minnows (Pimephales promelas) following brief or continuous exposure

Jarvinen, Alfred W.; Tanner, Danny K.; Kline, Edward R.; Knuth, Michael L.

doi:10.1016/0269-7491(88)90131-5

Cited by 41 publications

(17 citation statements)

References 19 publications

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“…However, scaling the elimination rate constant with volumetric length also requires that the relation between the effective area for exchange and the surface L 2 is comparable among species. For instance, in fish, the gill area is probably much larger than predicted from a scaling of arthropods based on volumetric length, which might help to explain that fish LC 50 values reported for TPT were lower than (Jarvinen et al, 1988) or comparable to (Antes et al, 2013) the toxicity values found for smaller sized arthropods in our study and elsewhere. Furthermore, body lipid content may play a role in toxicokinetics as TPT is highly lipophilic (log K OW of 3.53) and is taken up rapidly (Arnold et al, 1997).…”

Section: Prediction Of Interspecies Variationcontrasting

confidence: 58%

Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity

Gergs

Kulkarni

Preuß

2015

Environmental Pollution

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Section: Prediction Of Interspecies Variationcontrasting

confidence: 58%

Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity

Gergs

Kulkarni

Preuß

2015

Environmental Pollution

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“…Tas et al [16] found that guppies (Poecilia reticulata) exposed to different concentrations of TPT in the water died when the TPT in the body reached 2.2 g/g fish. Early life stages of fish are more susceptible to TPT; e.g., the larvae of the fathead minnow (Pimephales promelas) had a 96-h LC50 of 7.1 g/L for TPT hydroxide [17]. Survival of the larvae of the minnow Phoxinus phoxinus was significantly reduced at 1.8 g/L of TPT [18].…”

Section: Introductionmentioning

confidence: 98%

Triphenyltin and its degradation products in foliage and soils from sprayed pecan orchards and in fish from adjacent ponds

Kannan¹,

Lee²

1996

Enviro Toxic and Chemistry

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Abstract-Triphenyltin (TPT) is a fungicide used on a variety of crops throughout the world. In this study, pecan orchards in central Georgia (USA) previously sprayed with commercial TPT hydroxide mixtures were found to have TPT concentrations of 8.5 to 37 g/g dry weight in foliage and 1.2 to 12 g/g dry weight in soil. Total phenyltin concentrations (monophenyltin [MPT] ϩ diphenyltin [DPT] ϩ TPT) in foliage and soils immediately after application were up to 72 and 26 g/g dry weight, respectively. Besides TPT, DPT and MPT were present in the leaves and soils, with MPT generally the predominant compound. The proportion of MPT to TPT in pecan leaves increased with time after spraying, which was indicative of photolytic degradation of TPT. Microbial degradation of radiolableled TPT in soil or sediment samples was slow, with only 5% degraded during a 14-d incubation period. Triphenyltin was absent from the subsurface soils (2 to 15 cm depth) even though it had been sprayed eight to 10 times a year at a rate of 850 g/ha for the past 10 years. In an orchard where the last spraying was carried out approx. 2 years ago, TPT was absent, but MPT was present at approximately the same concentration as recently sprayed orchards. Fish (blue gill, largemouth bass, and channel catfish) from a pond near a recently sprayed pecan orchard had TPT as well as DPT and MPT. The predominate phenyltin in all fish was MPT, with 22 g/g wet weight in the liver of catfish. Radiolabeled TPT was only slowly metabolized by the fathead minnow, with 2% of the TPT metabolized to DPT after 6 d of exposure via water. Photodegradation appears to be the major factor affecting the fate of TPT in soils.

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“…Significant histological alterations in the skin, skeletal muscles, kidneys, corneal epithelium, lens and retina were observed in minnow larva on TBT exposure in the range of 0. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] µg/L. In this study, TBT concentrations of 20 µg/L or greater induced body axis distortion and degeneration of the tip of the tail fin bud, followed by histological alterations in the trunk muscle and skin degeneration, suggesting that these effects could be common for all fish larva.…”

Section: Discussionmentioning

confidence: 83%

“…On the other hand, the LC 50 value of TBT was 3.0 µg/L in silverside larva (Menidia beryllina) [1]. Although chemical forms are not always identical, acute LC 50 values have been reported as 5.8 µg/L in rainbow trout larva [3] and as 7.1 µg/L in fathead minnow larva for TPT [16]. Twenty-five µg/L TPT caused almost complete mortality by 120 hpf in developing zebrafish, supporting the relative resistance to organotin compounds in zebrafish larva [23].…”

Section: Discussionmentioning

confidence: 99%

Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish

Wang

Muramoto

Nagai

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Organotins are among the most common marine pollutants in the world, as they are widely used as antifouling paint on ships and fishing nets. It has been reported that organotin preferentially accumulates in the central nervous system, especially in the retinal neurons of marine organisms including fish. In this study, we investigated the effects of waterborne tributyltin (TBT) on early-stage developing zebrafish (Danio rerio). Below the lethal concentrations, TBT specifically increased the number of apoptotic cells in the retina as well as some cells near trigeminal neurons, detected by terminal transferase-mediated nick-end-labeling staining. Apoptosis peaked at 60 hpf and decreased by 72 hpf, which was associated with macrophage accumulation. Furthermore, the effect of TBT was markedly inhibited by antioxidants, ascorbic acid or trolox. These results suggest that TBT preferentially induces apoptosis in the retinal neuron of developing zebrafish. Oxidative stress may be involved in this toxicological response.

show abstract

Acute and chronic toxicity of triphenyltin hydroxide to fathead minnows (Pimephales promelas) following brief or continuous exposure

Cited by 41 publications

References 19 publications

Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity

Body size-dependent toxicokinetics and toxicodynamics could explain intra- and interspecies variability in sensitivity

Triphenyltin and its degradation products in foliage and soils from sprayed pecan orchards and in fish from adjacent ponds

Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish

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