Acute and delayed neurologic reaction to inoculation with attenuated live measles virus

Abe, Toshiaki; Nonaka, Chizuru; Hiraiwa, Mikio; Ushijima, Hiroshi; Fujii, R

doi:10.1016/s0387-7604(85)80140-6

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…In the North West Thames region of England between 1975 and 1981, there were 26 reports of convulsions out of 170,000 children who received the live measles vaccine [ 20 ]. Additional case series describe seizures after measles vaccination [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Neurological sequelae of vaccines

McAlpine

Zubair

2023

Neurol Sci

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Importance Vaccines are a safe and efficacious way to prevent a variety of infectious diseases. Over the course of their existence, vaccines have prevented immeasurable morbidity and mortality in humans. Typical symptoms of systemic immune activation are common after vaccines and may include local soreness, myalgias, nausea, and malaise. In the vast majority of cases, the severity of the infectious disease outweighs the risk of mild adverse reactions to vaccines. Rarely, vaccines may be associated with neurological sequela that ranges in severity from headache to transverse myelitis, acute disseminated encephalomyelitis, and Guillain–Barre syndrome (GBS). Often, a causal link cannot be confirmed, and it remains unclear if disease onset is directly related to a recent vaccination. Observations This review serves to summarize reported neurologic sequelae of commonly used vaccines. It will also serve to discuss potential pathogenesis. It is important to note that many adverse events or reactions to vaccines are self-reported into databases, and causal proof cannot be obtained. Conclusions and relevance Recognition of reported adverse effects of vaccines plays an important role in public health and education. Early identification of these symptoms can allow for rapid diagnosis and potential treatment. Vaccines are a safe option for prevention of infectious diseases.

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Section: Discussionmentioning

confidence: 99%