Acute and repeated gestational stress affect offspring learning and activity in rats

Weller, Aron; Glaubman, Hananyah; Yehuda, Shlomo; Caspy, Tamir; Ben-Uria, Yehuda

doi:10.1016/0031-9384(88)90229-6

Cited by 53 publications

(25 citation statements)

References 28 publications

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“…PS-induced learning and memory deficits are known to persist throughout adulthood. For instance, adult PS rats show deficits in appetitive operant learning test, which appear mainly during the reversal stage of the operant discrimination task, with no effect on acquisition, discrimination or extinction (Weller et al, 1988). Adult PS rats, mainly the male but not female offspring, spent more time searching for the platform location in a watermaze task, when the water is kept at 121C (Szuran et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Meunier

Gué

Récasens

et al. 2004

British J Pharmacology

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1 Stress during pregnancy results in complex neurochemical and behavioral alterations throughout the offspring lifetime. We here examined the impact of prenatal stress (PS) on memory functions in male and female offspring and report the efficacy of a selective sigma 1 (s 1 ) receptor agonist, igmesine, in alleviating the observed deficits. 2 Dams received an unpredictable 90-min duration restraint stress from gestational day E17 to E20. Learning was examined in offspring between day P24 and P36 using spontaneous alternation in the Y-maze, delayed alternation in the T-maze, water-maze learning and passive avoidance. 3 Both male and female PS rats showed impairments of spontaneous and delayed alternation performances. Acquisition of a fixed platform position in the water-maze was unchanged in PS rats, but the probe test revealed a diminution of time spent in the training quadrant. Acquisition of a daily changing platform position demonstrated impaired working memory for male and female PS rats. Finally, passive avoidance deficits were observed. 4 Pretreatment with the selective s 1 agonist igmesine (1-10 mg kg À1 i.p.) reversed the PS-induced learning deficits in offspring rats for each test. The s 1 antagonist BD1063 failed to affect performances alone but blocked the igmesine effect, confirming the involvement of the s 1 receptor. 5 PS thus induces delayed memory deficits, affecting spatial and nonspatial, short-and long-term memories in juvenile male and female offspring rats. Activation of the s 1 neuromodulatory receptor allows a significant recovery of the memory functions in PS rats.

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Section: Discussionmentioning

confidence: 99%

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Meunier

Gué

Récasens

et al. 2004

British J Pharmacology

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“…In addition, untreated depression during gestation can adversely affect mother-infant attachment, and infant development and maternal stress during pregnancy may induce neurobiological changes in the offspring (Lundy et al, 1999;Taylor et al, 2000). Extensive results from animal research suggest that maternal stress during pregnancy has adverse consequences for offspring growth (Schneider et al, 1999), learning ability (Weller et al, 1988), and postnatal development (Fride and Weinstock, 1984). These results suggest that there may be benefits to mother and infant from initiating or continuing antidepressant treatment during gestation, yet an understanding of the potential risks connected with in utero antidepressant exposure is required to make informed and patient-tailored choices.…”

Section: Antidepressantsmentioning

confidence: 99%

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

2004

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“…A number of learning and memory changes have also been observed. The most consistently reported are reduced rates of maze and reversal learning (Aleksandrov, Polyakova, & Batuev, 2001;Lemaire, Koehl, Le Moal, & Abrous, 2000;Weller, Glaubman, Yehuda, Caspy, & Ben-Uria, 1988).…”

mentioning

confidence: 99%

“…Performance on tests of attention, as measured through the sensorimotor gating task, prepulse inhibition (PPI; Barbazanges, Piazza, Le Moal, & Maccari, 1996;Lehmann, Stöhr, & Feldon, 2000), and locomotor activity (Deminière et al, 1992;Ordyan & Pivina, 2003;Weller et al, 1988) are also altered in these animals. In general, studies have suggested that prenatal stress has a greater effect on male rats.…”

mentioning

confidence: 99%

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

Burton¹,

Lovic²,

Fleming³

2006

Behavioral Neuroscience

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This study investigated the effects of prenatal stress and its interaction with artificial rearing (AR) on adult rat behavior. Pregnant dams underwent restraint stress from Gestational Day 10 to 21. After parturition, pups were raised by their mothers or in the AR paradigm, with or without stroking stimulation. In adulthood, rats were tested on prepulse inhibition (PPI), locomotor activity, elevated plus-maze, and spatial working memory. There were main effects and interactions of both prenatal stress and AR on activity. Additional stimulation reduced activity in nonstressed AR rats but increased activity in prenatally stressed AR rats. AR altered PPI and plus-maze behavior whereas additional stimulation partially reversed these effects. This study demonstrates that prenatal experiences can modulate the effects of postnatal treatments.

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Acute and repeated gestational stress affect offspring learning and activity in rats

Cited by 53 publications

References 28 publications

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

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Acute and repeated gestational stress affect offspring learning and activity in rats

Cited by 53 publications

References 28 publications

Attenuation by a sigma1 (σ1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Attenuation by a sigma1 (σ1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

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Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats