Acute and Subchronic Oral and Dermal Toxicological Studies of <i>Salvia Verbenaca</i> Extracts in Mice and Rats

Guaouguaou, Fatima-Ezzahrae; Taghzouti, Khalid; Oukabli, Mohamed; Masrar, Azlarab; Chabraoui, Layachi; Bouabdellah, Mounia; Es-Safi, Nour Eddine

doi:10.1080/10496475.2018.1556372

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…This direct skin injury may be a single, repeated, or prolonged contact with chemical substance to the skin [ 31 ]. The rat model, which is a well-established model for dermal toxicity studies [ 32 – 35 ], was used in this study as they were readily available and would offer easy comparative studies as the subsequent predictive studies in this research used rats as the preferred model for study. Again, rats are known to respond to therapies and their toxic effects in a way similar to humans hence can be used to predict the likelihood of a potential toxicity of an agent when administered to humans [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Dermal Toxicity and Wound Healing Activity of Cnestis ferruginea Vahl ex DC

Ankomah

Boakye

Agana

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Cnestisferruginea is a tropical plant, which is traditionally used in the treatment and management of various conditions including skin infections and wounds. The aim of this study was to investigate the dermal toxicity and wound healing potential of C. ferruginea. Ten millimeter full-thickness mucosal wounds were created on the dorsal midportion of the Sprague Dawley rats. Wounds were treated with 10, 5, and 2.5% w/w aqueous creams, prepared from the methanol extract of the root bark of C. ferruginea (CFM). The wound tissues were harvested on day 21 for histology studies. Compared with the untreated group, 10, 5, and 2.5% w/w CFM-treated wounds significantly reduced the wound size over the study period ( P < 0.0001 ). Tissue histology revealed a healed wound with well-regenerated collagen and skin appendages with no pus cells. A skin irritation test was conducted on CFM, as well as the dermal toxicity of CFM was determined in the repeated dose and acute dermal toxicity bioassays. These tests revealed that CFM showed no toxic effect on the skin and showed that CFM was not a skin irritant. C. ferruginea exhibited wound healing activity, which gives credence to its folkloric use.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Dermal Toxicity and Wound Healing Activity of Cnestis ferruginea Vahl ex DC

Ankomah

Boakye

Agana

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…However, some studies carried out recently have confirmed the safety of these plant extracts ( Table 8 ). Indeed, a report by Guaouguaou et al [ 64 ] focused on the acute and subchronic effects of S. verbenaca toxicity in mice and rats through oral and topical administration. The findings of the acute toxicity of the fractions derived from S. verbenaca (n-butanol, hexane, and ethyl acetate) demonstrated that the LD 50 of this plant after oral administration at 2000 mg kg −1 is not deadly [ 64 ].…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, a report by Guaouguaou et al [ 64 ] focused on the acute and subchronic effects of S. verbenaca toxicity in mice and rats through oral and topical administration. The findings of the acute toxicity of the fractions derived from S. verbenaca (n-butanol, hexane, and ethyl acetate) demonstrated that the LD 50 of this plant after oral administration at 2000 mg kg −1 is not deadly [ 64 ]. In order to complete the toxicity profile of this plant, more research should be done to find out how toxic it is over a long period of time.…”

Section: Methodsmentioning

confidence: 99%

Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Mrabti

Menyiy²,

Charfi

et al. 2022

BioMed Research International

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The family Lamiaceae contains several plants used in traditional medicine to fight against different diseases. Salvia verbenaca L. (S. verbenaca) is one of the Lamiaceae species distributed around the Mediterranean regions. This plant exhibits different bioactive properties, including antibacterial, anticancer, antioxidant, antileishmanial, antidiabetic, immunomodulatory, and wound healing. This review was conducted to revise previous studies on S. verbenaca addressing its botanical description, geographical distribution, and phytochemical, pharmacological, and toxicological properties. Moreover, the main pharmacological actions of S. verbenaca major compounds were well investigated. Literature reports have revealed that S. verbenaca possesses a pivotal role in medicinal applications. The findings of this work noted that S. verbenaca was found to be rich in chemical compound classes such as terpenoids, phenolics, fatty acids, sterols, and flavonoids. Numerous studies have found that S. verbenaca essential oils and extracts have a wide range of biological effects. These results support the potential pharmacological properties of S. verbenaca and its traditional uses. This analysis can constitute a scientific basis for further refined studies on its pure secondary metabolites. Therefore, the outcome of the present work may support the perspective of identifying new therapeutical applications with detailed pharmacological mechanisms of S. verbenaca to prevent the development of some diseases such as neurodegenerative disorders. However, toxicological investigations into S. verbenaca are needed to assess any potential toxicity before it can be further used in clinical studies.

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“…Noteworthy, the n -butanol extract was even more efficient than the standard SSD ® treatment. Following these experiments, Guaoguao et al [ 115 ] assessed the safety of a hydroalcoholic extract obtained from the aerial parts of S. verbenaca that was successively fractionated with hexane, ethyl acetate, and n -butanol. Crude residues were massaged in the shaved rat’s healthy skin.…”

Section: Pharmacological Wound Healing Evidence Of Iberian Lamiaceaementioning

confidence: 99%

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

et al. 2023

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Skin tissue has a crucial role in protecting the human body from external harmful agents, preventing wounds that frequently demand proper healing approaches. The ethnobotanical knowledge of specific regions with further investigation on their medicinal plants has been paramount to create new and effective therapeutical agents, including for dermatological purposes. This review attempts, for the first time, to investigate the traditional applications of Lamiaceae medicinal plants that are already used by local communities in the Iberian Peninsula in wound healing. Henceforward, Iberian ethnobotanical surveys were reviewed, and the information about the traditional wound healing practices of Lamiaceae was comprehensively summarized. Afterwards, the scientific validation of each Lamiaceae species was exhaustively checked. From this, eight out of twenty-nine Lamiaceae medicinal plants were highlighted by their wound-related pharmacological evidence and are in-depth presented in this review. We suggest that future studies should focus on the isolation and identification of the active molecules of these Lamiaceae, followed by robust clinical trials that may confirm the security and effectiveness of such natural-based approaches. This will in turn pave the way for more reliable wound healing treatments.

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Acute and Subchronic Oral and Dermal Toxicological Studies of Salvia Verbenaca Extracts in Mice and Rats

Cited by 8 publications

References 21 publications

Evaluation of Dermal Toxicity and Wound Healing Activity of Cnestis ferruginea Vahl ex DC

Evaluation of Dermal Toxicity and Wound Healing Activity of Cnestis ferruginea Vahl ex DC

Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

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